ChemicalBook > CAS DataBase List > 15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE

Product Name
15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE
CAS No.
2623-22-5
Chemical Name
15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE
Synonyms
15-mas;NSC-267030;deacetylanguidin;Desacetylanguidine;15-ACETOXYSCIRPENOL;monoacetoxyscirpenol;15-ACETOXYSCIRPENDIOL;Acetoxyscirpenol, 15-;15-MONOACETYLSCIRPENOL;15-MONOACETOXYSCIRPENOL
CBNumber
CB5379697
Molecular Formula
C17H24O6
Formula Weight
324.37
MOL File
2623-22-5.mol
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15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Property

Melting point:
170-172 °C
Boiling point:
465.5±45.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
≤10mg/ml in methanol;10mg/ml in dichloromethane
form 
powder
pka
13.72±0.70(Predicted)
color 
White to off-white
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
YD0111000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11431
Product name
15-acetoxy Scirpenol
Purity
≥98%
Packaging
1mg
Price
$242
Updated
2024/03/01
Cayman Chemical
Product number
11431
Product name
15-acetoxy Scirpenol
Purity
≥98%
Packaging
5mg
Price
$965
Updated
2024/03/01
Usbiological
Product number
412029
Product name
15-Acetoxyscirpenol
Packaging
1mg
Price
$885
Updated
2021/12/16
TRC
Product number
A164293
Product name
15-Acetoxyscirpenol
Packaging
10mg
Price
$4070
Updated
2021/12/16
ApexBio Technology
Product number
C4698
Product name
15-acetoxyScirpenol
Packaging
5mg
Price
$1104
Updated
2021/12/16
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15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

15-Acetoxyscirpenol is a trichothecene mycotoxin and an apoptosis inducer.

Hazard

A poison by ingestion. A mild skin irritant.

Biological Activity

15-acetoxy scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the fusarium genus [1]. 15-acetoxy scirpenol could induce apoptotic cell death in human jurkat t cells. mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus fusarium. acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). the 50% inhibitory concentration (ic50) values of 15-acetoxy scirpenol was 16.1 ng/ml [2]. in the jurkat t cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-mas), the populations of externalized ps-positive and pi-negative cells were 32.0% [2].

References

[1] peraica m, radic b, lucic a, et al. toxic effects of mycotoxins in humans[j]. bulletin of the world health organization, 1999, 77(9): 754-766.
[2] lee d h, park t, kim h w. induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving parp in jurkat t cells through treatment with acetoxyscirpenol mycotoxins[j]. biological and pharmaceutical bulletin, 2006, 29(4): 648-654.

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Preparation Products And Raw materials

Raw materials

Preparation Products

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15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Suppliers

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2623-22-5, 15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENERelated Search:

ENOLASE Octyl 4-methoxycinnamate (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL 3-METHOXYCYCLOHEXENE 1,3-CYCLOPENTANEDIOL 15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE 4-Methyl-2-(2-methyl-1-propenyl)tetrahydropyran (cis- and trans- mixture) Ethylhexylglycerin 1,1-DIETHYLCYCLOPROPANE (TETRAHYDRO-PYRAN-3-YL)-METHANOL 1-METHYL-3-CYCLOHEXENE-1-METHANOL 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL 3-METHYL-2-CYCLOHEXEN-1-OL 2-TERT-BUTYLPROPANE-1,3-DIOL 1-CYCLOPROPYLETHANOL (S)-1-CYCLOPROPYLETHANOL

  • deacetylanguidin
  • monoacetoxyscirpenol
  • 15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE
  • 15-ACETOXYSCIRPENDIOL
  • 15-ACETOXYSCIRPENOL
  • (3-alpha)-12,13-epoxytrichothec-9-ene-3,4,15-triol15-acetate
  • 15-mas
  • 4-beta,15-triol,12,13-epoxy-trichothec-9-ene-3-alph15-acetate
  • ((2R,2S,3R,5R,5AR,9aR)-3-hydroxy-5,8-dimethyl-2,3,4,5,5a,6,7,9a-octahydrospiro[2,5-methanobenzo[b]oxepine-10,2-oxiran]-5a-yl)methyl acetate
  • 15-acetoxy-3α,4β-dihydroxy-12,13-epoxytrichothec-9-ene
  • 15-MONOACETYLSCIRPENOL
  • 15-MONOACETOXYSCIRPENOL
  • 15-Acetoxyscirpendiol, 15-Acetoxy-3α,4β-dihydroxy-12,13-epoxytrichothec-9-ene
  • 12,13-Epoxytrichothec-9-ene-3α,4β,15-triol 15-acetate
  • 3α,4β-Dihydroxy-15-acetoxy-12,13-epoxytrichotheca-9-ene
  • NSC-267030
  • Anguidine, desacetyl(15-acetoxyscirpene-3,4-diol-bl5732)
  • Desacetylanguidine
  • Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 15-acetate, (3.alpha.,4.beta.)-
  • Trichothec-9-ene-3.alpha.,4.beta.,15-triol, 12,13-epoxy-, 15-acetate
  • 15 Acetoxyscirpenol (3alpha,4beta)-12,13-epoxy-trichothec-9-ene-3,4,15-triol 15-acetate
  • Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 15-acetate, (3α,4β)-
  • Trichothec-9-ene-3.α.,4.β.,15-triol, 12,13-epoxy-, 15-acetate
  • ((2S,2'R,3'R,5'R,5a'R,9a'R)-3'-Hydroxy-5',8'-dimethyl-2',3',4',5',7',9a'-hexahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-5a'(6'H)-yl)methyl acetate
  • 15-Acetoxyscirpenol in acetonitrile
  • Acetoxyscirpenol-15 in Acetonitrile
  • Acetoxyscirpenol, 15-
  • 2623-22-5