ChemicalBook > CAS DataBase List > Ascomycin

Ascomycin

Product Name
Ascomycin
CAS No.
11011-38-4
Chemical Name
Ascomycin
Synonyms
AAG;FK-520;CS-740;CGTHBA;Ascomycin;FR-900520;Nsc106410;Aids093221;IMMUNOMYCIN;Aids-093221
CBNumber
CB5406331
Molecular Formula
C43H69NO12
Formula Weight
792.01
MOL File
11011-38-4.mol
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Ascomycin Property

Melting point:
158 - 161°C
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).
form 
White crystalline solid
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety

RTECS 
CI7570000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB2501813
Product name
Anti-Nprl3 antibody produced in goat
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100μG
Price
$568
Updated
2024/03/01
Sigma-Aldrich
Product number
182800
Product name
Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem
Purity
An ethyl analog of FK506 with similar immunosuppressant properties.
Packaging
1mg
Price
$205
Updated
2022/05/15
Usbiological
Product number
207066
Product name
Ascomycin
Packaging
1mg
Price
$273
Updated
2021/12/16
Usbiological
Product number
A3698-75
Product name
Ascomycin
Packaging
25mg
Price
$196
Updated
2021/12/16
Biorbyt Ltd
Product number
orb545956
Product name
Ascomycin
Purity
>98%
Packaging
25mg
Price
$280.5
Updated
2021/12/16
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Ascomycin Chemical Properties,Usage,Production

Description

Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays anti-inflammatory effects in skin diseases3. Cell permeable and active in vivo.

Uses

A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases.

General Description

An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.

Biochem/physiol Actions

Product does not compete with ATP.

Enzyme inhibitor

This antifungal antibiotic (FW = 792.02 g/mol; CAS 104987-12-4; Solubility: 50 mM in DMSO), also known as FK520, isolated from Streptomyces hygroscopicus, is also a powerful immunosuppressant. Note that ascomycin is a structural analogue of tacrolimus (or FK506) and, as such, operates by a similar mechanism of action (See Tacrolimus). Ascomycin inhibits allogenic T-lymphocyte proliferation and calcineurin phosphatase activity.

References

1) Hatanaka et al. (1988), FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physio-chemical and biological characteristics; J. Antibiot. (Tokyo), 41 1592 2) Petros et al. (1991), NMR studies of an FK506 analogue [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding; J. Med. Chem., 34 2925 3) Mollison et al. (1999), A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases; J. Invest. Dermatol., 112 729

Ascomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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Ascomycin Suppliers

Australia 1 China 167 Germany 5 India 2 Switzerland 2 United Kingdom 2 United States 12 Global 191
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View Lastest Price from Ascomycin manufacturers

Dideu Industries Group Limited
Product
Ascomycin 11011-38-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2024-04-23
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Ascomycin 11011-38-4
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-16
Hangzhou ICH Biofarm Co., Ltd
Product
Ascomycin 11011-38-4
Price
US $0.00-0.00/g
Min. Order
100g
Purity
99.5%
Supply Ability
100kg
Release date
2023-07-04

11011-38-4, AscomycinRelated Search:

ISOXADIFEN-ETHYL Ethyl formate Trinexapac-ethyl Minocycline hydrochloride Ascomycin Gentamicin Oxytetracycline dihydrate Clindamycin 2-Ethoxyethanol Ethyl acetate Ethanol Chlortetracycline Azithromycin Ethyl propionate Ethylparaben SPECTINOMYCIN DIHYDROCHLORIDE Paclitaxel Hyodeoxycholic acid

  • ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS
  • ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS VAR ASCOMYCETICUS
  • FR-900520
  • FK-520
  • IMMUNOMYCIN
  • AAG
  • ASCOMYCIN (IMMUNOMYCIN, FR-900520) \ INH IBITS CALCINEURIN (PP2B)
  • (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
  • Ascomycin
  • Ascomycin (FK520)
  • 15,19-Epoxy-3H-pyrido[2,1-C][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26as)-
  • Aids093221
  • Aids-093221
  • CS-740
  • Ascomycin (Immunomycin
  • Nsc106410
  • Anti-Nprl3 antibody produced in goat
  • CGTHBA
  • nitrogen permease regulator-like 3 (S. cerevisiae)
  • RP23-177M10.6
  • Ascomycin, >=98.5%
  • Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem
  • Ascomycin (Immunomycin,FK-520)
  • Ascomycin 1
  • 17-Ethyl-1,14-dihydroxy-12-[1-(4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl]-23,25-dimethoxy-13,19,2
  • 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
  • 11011-38-4
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics A-F
  • BioChemical
  • API
  • Immunosuppressant