ChemicalBook > CAS DataBase List > 2,3-Dichloroquinoxaline

2,3-Dichloroquinoxaline

Product Name
2,3-Dichloroquinoxaline
CAS No.
2213-63-0
Chemical Name
2,3-Dichloroquinoxaline
Synonyms
cp42103-4;NSC 33437;oroquinoxaL;AKOS BBS-00006726;TIMTEC-BB SBB003555;SALOR-INT L497169-1EA;3-Dichloroquinoxaline;2,3-DICHLOROQUINOXALINE;2,3-dichloro-quinoxalin;2,3-Dichlcroquinoxaline
CBNumber
CB5414800
Molecular Formula
C8H4Cl2N2
Formula Weight
199.04
MOL File
2213-63-0.mol
More
Less

2,3-Dichloroquinoxaline Property

Melting point:
152-154 °C (lit.)
Boiling point:
325.69°C (rough estimate)
Density 
1.4994 (rough estimate)
refractive index 
1.6400 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Water Solubility 
Insoluble in water
solubility 
soluble in Chloroform
form 
Needles
pka
-4.78±0.48(Predicted)
color 
Off-white to light brown
BRN 
126076
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
SPSSDDOTEZKOOV-UHFFFAOYSA-N
CAS DataBase Reference
2213-63-0(CAS DataBase Reference)
EPA Substance Registry System
2,3-Dichloroquinoxaline (2213-63-0)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-36/37/39-45-37/39-28A
RIDADR 
2811
WGK Germany 
3
RTECS 
VD1720000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29339900
Toxicity
mouse,LD50,intravenous,5600ug/kg (5.6mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03256,
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
144525
Product name
2,3-Dichloroquinoxaline
Purity
96%
Packaging
10g
Price
$59.9
Updated
2024/03/01
Sigma-Aldrich
Product number
144525
Product name
2,3-Dichloroquinoxaline
Purity
96%
Packaging
50g
Price
$274
Updated
2023/06/20
TCI Chemical
Product number
D2622
Product name
2,3-Dichloroquinoxaline
Purity
>98.0%(GC)
Packaging
5g
Price
$48
Updated
2024/03/01
TCI Chemical
Product number
D2622
Product name
2,3-Dichloroquinoxaline
Purity
>98.0%(GC)
Packaging
25g
Price
$145
Updated
2024/03/01
Alfa Aesar
Product number
A11734
Product name
2,3-Dichloroquinoxaline, 98%
Packaging
25g
Price
$142.65
Updated
2024/03/01
More
Less

2,3-Dichloroquinoxaline Chemical Properties,Usage,Production

Description

2,3-Dichloroquinoxaline (DCQX) can be used as a substrate for nucleophilic aromatic substitution (SNAr) reactions and is a versatile building block for the synthesis of many quinoxaline derivatives. 2,3-Dichloroquinoxaline reacts with 6-aminothiouracil in ethanol/TEA to form 6-amino-2-(3-chloroquinoxalin-2-ylthio)pyrimidin-4(3H)-one. It reacts with cholest-5-en-3-one semicarbazone/thiosemicarbazone to form steriodal cholest-5-en-3-oxazolo and thiazoloquinoxaline.

Chemical Properties

solid

Uses

2,3-Dichloroquinoxaline is a dichlorinated quinoxaline derivative with antimicrobial activity. 2,3-Dichloroquinoxaline is used in the preparation of quinoxaline derivatives of cancer chemopreventive a ctivity.

Uses

2,3-Dichloroquinoxaline was used in the synthesis of mono and 2,3-disubstituted quinoxalines. It was used in solid phase synthesis of HPLC chiral stationary phase containing the N,N′-dialkyl-2,3-diaminoquinoxaline group as a linking structure.

Preparation

To a stirred solution of quinoxaline-2,3(1H,4H)-dione (5.00 g, 1.0 equiv.), POCl3 was added (20 ml) and refluxed at 100 °C for 3h. After completion of the reaction, as indicated by TLC, the reaction mass was distilled under vaccum and quenched with ice cold water. Off white semi solid was formed and is filtered through buchner funnel under vaccum to yield the 2,3-dichloroquinoxaline in excellent yield.

Appearance: off white solid; Yield: 92% (5.64g); ESI-MS: (m/z) calcd. for C8H4Cl2N2: 197.98, found: 199.10 [M+H]+.

General Description

Gray solid. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Fire Hazard

2,3-Dichloroquinoxaline is probably combustible.

Purification Methods

Recrystallise it from *C6H6 and dry it in a vacuum [Cheeseman J Chem Soc 1804 1955, Beilstein 23/7 V 144].

2,3-Dichloroquinoxaline Preparation Products And Raw materials

Raw materials

Preparation Products

2-CHLORO-3-(4-MORPHOLINYL)QUINOXALINE 2 CHLORO-3-AMINO QUINOXALINE 2-CHLORO-3-(3,5-DIMETHYL-PYRAZOL-1-YL)-QUINOXALINE
More
Less

2,3-Dichloroquinoxaline Suppliers

Americas 1 Belgium 3 Canada 2 China 267 Czech Republic 2 Europe 1 France 1 Germany 8 Hungary 1 India 22 Japan 4 South Korea 1 Switzerland 2 The Netherlands 3 Ukraine 2 United Kingdom 13 United States 47 Global 380
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
Aston Chemical
Tel
13000000000
Email
sales@astonchem.com
Country
United States
ProdList
1634
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Thoreau Chem Limited
Tel
--
Fax
--
Email
sales@thoreauchem.com
Country
United States
ProdList
483
Advantage
50
Chemphtec Corporation
Tel
--
Fax
--
Email
fo@chemphtec.com
Country
United States
ProdList
2181
Advantage
58
Crescent Chemical Company
Tel
--
Fax
--
Email
fran@creschem.com
Country
United States
ProdList
1441
Advantage
58
TCI America, Inc. (Tokyo Chemical Industry Co., Ltd.)
Tel
--
Fax
--
Email
.Crew@tcichemicals.com
Country
United States
ProdList
3164
Advantage
58
Wilshire Technologies, Inc.
Tel
--
Fax
--
Email
info@wilshiretechnologies.com
Country
United States
ProdList
893
Advantage
58
AstaTech, Inc.
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
904
Advantage
58
eNovation Chemicals LLC
Tel
--
Fax
--
Email
ales@eNovationChem.com
Country
United States
ProdList
1673
Advantage
58
Combi-Blocks, Inc.
Tel
--
Fax
--
Email
les@combi-blocks.com
Country
United States
ProdList
2555
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
SynQuest Laboratories, Inc. (Part of Central Glass Co., Ltd.)
Tel
--
Fax
--
Email
nfo@synquestlabs.com
Country
United States
ProdList
1897
Advantage
58
2A Biotech USA
Tel
--
Fax
--
Email
info@2abiotech.com
Country
United States
ProdList
1785
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
MP Biomedicals, LLC. (Division of Valiant FC Co., Ltd.)
Tel
--
Fax
--
Email
serv@mpbio.com
Country
United States
ProdList
1854
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
Wilshire Technologies
Tel
--
Fax
--
Country
United States
ProdList
428
Advantage
58
Advanced Chemical Intermediates Ltd.
Tel
--
Fax
--
Email
enquiries@acints.com
Country
United States
ProdList
4893
Advantage
58
Heterocyclics Inc
Tel
--
Fax
--
Email
info@heterocyclics.com
Country
United States
ProdList
1669
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
AstaTech, Inc
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
6371
Advantage
58
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Advanced Synthesis Technologies
Tel
--
Fax
--
Email
sales@advancedsynthesis.com
Country
United States
ProdList
4775
Advantage
61
www.vwrsp.com
Tel
--
Fax
--
Email
B2B@VWR.com
Country
United States
ProdList
622
Advantage
86
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
TimTec Corporation
Tel
--
Fax
--
Email
info@timtec.net
Country
United States
ProdList
6891
Advantage
68
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
More
Less

View Lastest Price from 2,3-Dichloroquinoxaline manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2,3-Dichloroquinoxaline 2213-63-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
2,3-Dichloroquinoxaline 2213-63-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.00%
Supply Ability
100tons
Release date
2023-09-26
Hebei Chuanghai Biotechnology Co,.LTD
Product
2, 3-Dichloroquinoxaline 2213-63-0
Price
US $10.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10 ton
Release date
2024-08-13

2213-63-0, 2,3-DichloroquinoxalineRelated Search:

Quinclorac CHLOROQUINE Quinoxaline 1,3-Dichloropropene Dichlorodimethylsilane N,N-Dimethylacetamide Sodium dichloroisocyanurate Thionyl chloride Dichloroethane 2,3,6-TRICHLOROQUINOXALINE 2,3-DICHLORO-6,7-DINITROQUINOXALINE 2,3-DICHLORO-6,7-DIMETHYLQUINOXALINE 2,3-DICHLORO-6-METHYLQUINOXALINE 2,3-DICHLORO-6,7-DIMETHOXYQUINOXALINE 2,3,6,7-TETRACHLOROQUINOXALINE 6-bromo-2,3-dichloroquinoxaline 2,7-DICHLORO-QUINOXALINE 2,6-DICHLOROQUINOXALINE 95%,2,6-DICHLOROQUINOXALINE

  • 2,3-dichloro-quinoxalin
  • cp42103-4
  • AKOS BBS-00006726
  • 2,3-DICHLOROQUINOXALINE
  • SALOR-INT L497169-1EA
  • TIMTEC-BB SBB003555
  • Quinoxaline, 2,3-dichloro.
  • 2,3-Dichloroquinoxaline ,98%
  • 2,3-Dichloroquinoxaline,97%
  • NSC 33437
  • 2,3-Dichloroquinoxaline,96%
  • 3-Dichloroquinoxaline
  • 2,3-Dichloroquinoxaline, 97% 10GR
  • 2,3-dichloroquinoxazoline
  • 2,3-Dichloroquinoxaline, 97.5%
  • 2,3-dichloroquinoxaline2213-63-0
  • 2,3-Dichlcroquinoxaline
  • JR-8372, 2,3-Dichloroquinoxaline, 97%
  • 2,3-Dichloroquinoxaline&gt
  • oroquinoxaL
  • 2213-63-0 2,3-Dichloroquinoxaline
  • 6H-Benzo[cd]pyren-11-one
  • 4-Hydroxybenzaldehyde,p-Hydroxybenzaldehyde,4-Hydroxybenzenecarbonal,Para Hydroxy Benzaldehyde,PHB,p-hydroxy-benzaldehyd,4-hydroxybenzaldehyde,p-Formylphenol,p-Oxybenzaldehyde,USAF m-6
  • 2213-63-0
  • 2212-63-0
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Quinoxalines
  • Building Blocks
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Quinoxalines
  • QuinoxalinesHeterocyclic Building Blocks
  • 1
  • 2213-63-0