HYDROFLUMETHIAZIDE

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HYDROFLUMETHIAZIDE

Product Name: HYDROFLUMETHIAZIDE
CAS No.: 135-09-1
Chemical Name: HYDROFLUMETHIAZIDE
Synonyms: hydol;River;naclex;Ademil;rontyl;elodrin;finuret;bristab;saluron;sisuril
CBNumber: CB5416596
Molecular Formula: C8H8F3N3O4S2
Formula Weight: 331.29
MOL File: 135-09-1.mol

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HYDROFLUMETHIAZIDE Property

Melting point:: 272-273
Boiling point:: 531.6±60.0 °C(Predicted)
Density: 1.5955 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Sparingly)
pka: 8.9, 8.2(at 25℃)
form: Solid
color: White
Water Solubility: 329.9mg/L(room temperature)
EPA Substance Registry System: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide (135-09-1)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 42/43
Safety Statements: 36
WGK Germany: 2
RTECS: DK9625000
Hazard Note: Irritant
HS Code: 2935904000
Hazardous Substances Data: 135-09-1(Hazardous Substances Data)
Toxicity: LD50 in mice (mg/kg): >8000 orally, 750 i.v., 6280 i.p. (Piala)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1322007
Product name: Hydroflumethiazide
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $893
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP190
Product name: Hydroflumethiazide
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $243
Updated: 2022/05/15

Cayman Chemical

Product number: 23612
Product name: Hydroflumethiazide
Purity: ≥98%
Packaging: 50mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 23612
Product name: Hydroflumethiazide
Purity: ≥98%
Packaging: 100mg
Price: $193
Updated: 2024/03/01

TRC

Product number: H714630
Product name: Hydroflumethiazide
Packaging: 100mg
Price: $135
Updated: 2021/12/16

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HYDROFLUMETHIAZIDE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Saluron,Bristol,US,1959

Uses

Labelled Hydroflumethiazide. Antihypertensive; diuretic.

Definition

ChEBI: Hydroflumethiazide is a benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a thiazide.

Manufacturing Process

(a) Preparation of 5-Trifluoromethylaniline-2,4-Disulfonyl Chloride: 113 ml of chlorosulfonic acid was cooled in an ice-bath, and to the acid was added dropwise while stirring 26.6 grams of α,α,α-trifluoro-m-toluidine. 105 grams of sodium chloride was added during 1 to 2 hours, whereafter the temperature of the reaction mixture was raised slowly to 150° to 160°C, which temperature was maintained for 3 hours. After cooling the mixture, ice-cooled water was added, whereby 5-trifluoromethylaniline-2,4-disulfonyl chloride separated out from the mixture.
(b) Preparation of 5-Trifluoromethyl-2,4-Disulfamylaniline: The 5- trifluoromethylaniline-2,4-disulfonyl chloride obtained in step (a) was taken up in ether and the ether solution dried with magnesium sulfate. The ether was removed from the solution by distillation, the residue was cooled to 0°C and 60 ml of ice-cooled, concentrated ammonia water was added while stirring. The solution was then heated for one hour on a steam bath and evaporated in vacuo to crystallization. The crystallized product was 5-trifluoromethyl-2,4- disulfamylaniline, which was filtered off, washed with water and dried in a vacuum exsiccator over phosphorus pentoxide. After recrystallization from a mixture of 30% ethanol and 70% water the compound had a MP of 247° to 248°C.
(e) Preparation of 6-Trifluoromethyl-7-Sulfamyl-3,4-Dihydro-1,2,4- Benzothiadiazine-1,1-Dioxide: 3.2 grams of 5-trifluoromethyl-2,4- disulfamylaniline was added to a solution of 0.33 gram of paraformaldehyde in 25 ml of methyl Cellosolve (2-methoxy ethanol) together with a catalytic amount of p-toluenesulfonic acid, and the mixture was boiled with reflux for 5 hours. The solvent was then distilled off in vacuo, and the residue triturated with 30 ml of ethyl acetate. 6-trifluoromethyl-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide crystallized out. After recrystallization from methanol/water the substance had a MP of 272° to 273°C.

Therapeutic Function

Diuretic, Antihypertensive

HYDROFLUMETHIAZIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from HYDROFLUMETHIAZIDE manufacturers

Dideu Industries Group Limited

Product: HYDROFLUMETHIAZIDE 135-09-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-08

135-09-1, HYDROFLUMETHIAZIDERelated Search:

4-(Trifluoromethyl)benzenesulfonamide 4-(TRIFLUOROMETHYL)THIOPHENOL 2-(TRIFLUOROMETHYL)THIOPHENOL Benzenesulfonamide, 2-(methylamino)- (9CI) HYDROFLUMETHIAZIDE 4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide penflutizide BENDROFLUMETHIAZIDE 2-(Trifluoromethyl)benzenesulfonamide 2-Aminobenzenesulfonamide 2-AMINO-4-(TRIFLUOROMETHYL)THIOPHENOL3-AMINO-4-MERCAPTOBENZOTRIFLUORIDE 2-AMINO-N-METHYLBENZENESULFONAMIDE

dihydroflumethazide

dihydroflumethiazide

diucardin

diuredemina

diurometon

elodrin

elodrine

finuret

flutizide

glomerulin

hidroalogen

hidroflumetiazid

hydol

hydrenox

hydroflumethizide

leodrine

metflorylthiazidine

methforylthiazidine

naciex(glaxo)

naclex

olmagran

3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-Benzothiadiazine-7-sulphonamide-1,1-dioxide95+%

Hudroflumethiazide

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

HYDROFLUMETHIAZIDE,USP

Ademil

River

Hydroflumethiazide (200 mg)

Hydroumethiazide (200 mg)

6-(trifluoroMethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonaMide 1,1-dioxide

1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

3,4-DIHYDRO-6-(TRIFLUOROMETHYL)-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE-1,1-DIOXIDE

3,4-DIHYDRO-6-(TRIFLUOROMETHYL)-2H-1,2,4-BENZOTHIADIAZINE-7-SULPHONAMIDE-1,1-DIOXIDE

HYDROFLUMETHIAZIDE

1,1-DIOXO-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDRO-1L-6-2-4-BENZATHIADIAZINE-7-SULFONAMIDE

1,1-DIOXO-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDRO-1LAMBDA6,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE

3,4-dihydro-6-trifluoromethyl-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dio

3,4-dihydro-6-trifluoromethyl-7-sulfamoylbenzo-1,2,4-thiadiazine1,1-dioxide

3,4-dihydro-7-sulfamyl-6-trifluoromethyl-2h-1,2,4-benzothiadiazine1,1-dioxid

4-benzothiadiazine-7-sulfonamide,3,4-dihydro-6-(trifluoromethyl)-,1,1-2h-2

6-trifluoromethyl-3,4-dihydro-7-sulfamoyl-2h-1,2,4-benzothiadiazine1,1-dioxi

6-trifluoromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide

7-sulfamyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide

bristab

bristurin

di-ademil

di-adenil

1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide

1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide

rodiuran

rontyl

saluron

sisuril

spandiuril

trifluoromethylhydrazide

trifluoromethylhydrothiazide

HYDROFLUMETHIAZIDE USP/EP/BP

HydroflumethiazideQ: What is Hydroflumethiazide Q: What is the CAS Number of Hydroflumethiazide Q: What is the storage condition of Hydroflumethiazide Q: What are the applications of Hydroflumethiazide