1,1-DIMETHOXYCYCLOHEXANE Property

Boiling point:

83 °C/50 mmHg (lit.)

Density 

0.948 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.439(lit.)

Flash point:

50°C

solubility 

Chloroform (Soluble), Ethyl Acetate (Slightly)

form 

clear liquid

color 

Colorless to Yellow

CAS DataBase Reference

933-40-4(CAS DataBase Reference)

Safety

Risk Statements 

10-18

Safety Statements 

16-51

RIDADR 

3271

WGK Germany 

3

HS Code 

2911.00.5000

HazardClass 

3

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

1,1-DIMETHOXYCYCLOHEXANE Chemical Properties,Usage,Production

Uses

1,1-Dimethoxycyclohexane is a useful research chemical used in the preparation of N-??substituted valiolamine derivatives as potential oral antidiabetic agents.

Synthesis Reference(s)

Canadian Journal of Chemistry, 61, p. 366, 1983 DOI: 10.1139/v83-065
Tetrahedron Letters, 30, p. 6151, 1989 DOI: 10.1016/S0040-4039(01)93328-3

General Description

Cyclohexanone dimethyl ketal reacts with trimethylsilane in the presence of trimethylsilyl triflate to form the corresponding ether. It can also undergo allylation and propargylation in the presence of indium to form the corresponding homoallylic or homopropargylic alcohol, respectively.