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Allopregnanolone

Product Name
Allopregnanolone
CAS No.
516-54-1
Chemical Name
Allopregnanolone
Synonyms
Brexanolone;ALLOPREGNANOLONE;Anlotinib Dihydrochloride;(3a)-Allopregnanolone;allotetrahydroprogesterone;3α-hydroxy-5α-pregnan-20-one;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one;5α-P;3α-OH-DHP;LJPC-0712
CBNumber
CB5418550
Molecular Formula
C21H34O2
Formula Weight
318.49
MOL File
516-54-1.mol
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Allopregnanolone Property

Melting point:
176-178°
alpha 
D +87.7° (abs alc)
Boiling point:
431.2±18.0 °C(Predicted)
Density 
1.053±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
chloroform: 20 mg/mL, clear, colorless
form 
White solid
pka
15.12±0.70(Predicted)
color 
white
Merck 
13,272
BRN 
3211363
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey
AURFZBICLPNKBZ-SYBPFIFISA-N
CAS DataBase Reference
516-54-1(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
TU4383000
10
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P8887
Product name
5α-Pregnan-3α-ol-20-one
Purity
solid
Packaging
5mg
Price
$211
Updated
2024/03/01
Cayman Chemical
Product number
16930
Product name
Allopregnanolone
Purity
≥98%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
16930
Product name
Allopregnanolone
Purity
≥98%
Packaging
5mg
Price
$160
Updated
2024/03/01
Sigma-Aldrich
Product number
P8887
Product name
5α-Pregnan-3α-ol-20-one
Purity
solid
Packaging
10mg
Price
$254
Updated
2024/03/01
Cayman Chemical
Product number
16930
Product name
Allopregnanolone
Purity
≥98%
Packaging
10mg
Price
$239
Updated
2024/03/01
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Allopregnanolone Chemical Properties,Usage,Production

Description

Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone . It acts as a positive allosteric modulator of GABAA receptors at nM concentrations (exhibiting the greatest potentiation at isoforms containing δ subunits) and of GABAC receptors at μM concentrations. Allopregnanolone displays effects similar to other GABAA receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.

Uses

(3α)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3α)-Allopregnanolone is a metabolite of Progesterone (P755900). (3α)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain.

Definition

ChEBI: Brexanolone is a 3-hydroxy-5alpha-pregnan-20-one in which the hydroxy group at position 3 has alpha-configuration. It is a metabolite of the sex hormone progesterone and used for the treatment of postpartum depression in women. It has a role as a human metabolite, an antidepressant, a GABA modulator, an intravenous anaesthetic and a sedative.

Biological Activity

GABA A receptor positive allosteric modulator. Neuroactive steroid.

storage

Room temperature

References

1) Belelli and Lambert (2005),?Neurosteroids: endogenous regulators of the GABA(A) receptor; Nat. Rev. Neurosci,,?6?565 2) Reddy?et al. (2010),?Neurosteroids: endogenous role in the human brain and therapeutic potentials; Prog. Brain Res.,?186?113 3) Frieder?et al. (2019),?Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development; CNS Drugs,?33?265 4) Balan?et al.?(2019),?Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Proinflammatory Signaling in Macrophages and Brain; Sci. Rep.,?9?1220 5) Chang?et al.?(2019),?Neurosteroid allopregnanolone inhibits glutamate release from rat cerebrocortical nerve terminals; Synapse,?73?e22076 6) Cho?et al.?(2018),?Increased Superoxide Dismutase 2 by Allopregnanolone Ameliorates ROS-Mediated Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus; Neurochem. Res.,?43?1464

Allopregnanolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Allopregnanolone Suppliers

Hunan Yuanye Pharmaceutical Co., Ltd.
Tel
0731-85589467; 13574065797
Email
2675013845@qq.com
Country
China
ProdList
33
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Jinan Chenghui Shuangda biological Co., LTD
Tel
0531-58897003 15550412551
Fax
0531-58897003
Email
market@jnchsd.com
Country
China
ProdList
209
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9442
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3404
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366 15920483169
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17944
Advantage
56
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View Lastest Price from Allopregnanolone manufacturers

PNP Biotech Co. Ltd
Product
Brexanolone 516-54-1
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2022-10-19
shandong perfect biotechnology co.ltd
Product
5alpha-Pregnan-3alpha-ol-20-one 516-54-1
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1kg
Release date
2023-08-03
Hebei Xinsheng New Material Technology Co., LTD.
Product
ALLOPREGNAN-3ALPHA-OL-20-ONE 516-54-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20tons
Release date
2023-09-13

516-54-1, AllopregnanoloneRelated Search:


  • 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
  • 3-A-5-A-TETRAHYDROPROGESTERONE
  • 3-alpha,5-alpha-pregnanolone
  • 3α-OH-DHP
  • Anlotinib Dihydrochloride
  • Allopregnanolone(Brexanolone)
  • LJPC-0712
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  • (3α)-Allopregnanolone
  • 3α,5α-Tetrahydroprogesterone
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  • 3α-Hydroxy-5α-dihydroprogesterone
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  • 5α-P
  • 3Α;5Α-THP; SAGE547; SAGE 547; SAGE-547
  • 3A-HYDROXY-5A-PREGNAN-20-ONE
  • (3a)-Allopregnanolone
  • Allopregnanolone - CAS 516-54-1 - Calbiochem
  • Brexanolone(SAGE-547)
  • 3-alpha,5-alpha-tetrahydroprogesterone
  • 3-alpha-hydroxy-5-alpha-pregnan-20-on
  • 5alpha-Pregnan-20-one, 3alpha-hydroxy-
  • allotetrahydroprogesterone
  • Pregnan-20-one, 3-hydroxy-, (3alpha,5alpha)-
  • 5ALPHA-PREGNAN-3ALPHA-OL-20-ONE
  • 3ALPHA-HYDROXY-5ALPHA-20-ONE
  • 3ALPHA-HYDROXY-5ALPHA-PREGNAN-20-ONE
  • 3ALPHA-OH-DHP
  • ALLOPREGNAN-3ALPHA-OL-20-ONE
  • ALLOPREGNANOLONE
  • 3α-hydroxy-5α-pregnan-20-one
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  • 5a-Pregnan-3alpha-ol-3-one
  • 3α-Hydroxy-5α-pregnan-20-one, 3α-OH-DHP, Allopregnan-3α-ol-20-one
  • 1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
  • 5alpha-Pregnan-3alpha-ol-20-one,3α-hydroxy-5α-pregnan-20-one
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  • Alpha - Pregnan - alpha - 3 ol - twenty - one, Brexanolone
  • 5α-Pregnan-3α-ol-20-one
  • (3α,5β)-3-Hydroxy-pregnan-20-one
  • Allopregnan-3α-ol-20-one
  • (3alpha)-Allopregnanolone
  • 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10
  • 5alpha progesterone 3alpha alcohol 20 one (tetrahydro progesterone)
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  • 3α,5α-THP
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