Allopregnanolone
- Product Name
- Allopregnanolone
- CAS No.
- 516-54-1
- Chemical Name
- Allopregnanolone
- Synonyms
- Brexanolone;ALLOPREGNANOLONE;Anlotinib Dihydrochloride;(3a)-Allopregnanolone;allotetrahydroprogesterone;3α-hydroxy-5α-pregnan-20-one;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one;5α-P;ASN16541;3α-OH-DHP
- CBNumber
- CB5418550
- Molecular Formula
- C21H34O2
- Formula Weight
- 318.49
- MOL File
- 516-54-1.mol
Allopregnanolone Property
- Melting point:
- 176-178°
- alpha
- D +87.7° (abs alc)
- Boiling point:
- 431.2±18.0 °C(Predicted)
- Density
- 1.053±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- chloroform: 20 mg/mL, clear, colorless
- form
- White solid
- pka
- 15.12±0.70(Predicted)
- color
- white
- Merck
- 13,272
- BRN
- 3211363
- Stability:
- Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- InChIKey
- AURFZBICLPNKBZ-SYBPFIFISA-N
- CAS DataBase Reference
- 516-54-1(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- P8887
- Product name
- 5α-Pregnan-3α-ol-20-one
- Purity
- solid
- Packaging
- 5mg
- Price
- $211
- Updated
- 2024/03/01
- Product number
- 16930
- Product name
- Allopregnanolone
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 16930
- Product name
- Allopregnanolone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $160
- Updated
- 2024/03/01
- Product number
- P8887
- Product name
- 5α-Pregnan-3α-ol-20-one
- Purity
- solid
- Packaging
- 10mg
- Price
- $254
- Updated
- 2024/03/01
- Product number
- 16930
- Product name
- Allopregnanolone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $239
- Updated
- 2024/03/01
Allopregnanolone Chemical Properties,Usage,Production
Description
Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone . It acts as a positive allosteric modulator of GABAA receptors at nM concentrations (exhibiting the greatest potentiation at isoforms containing δ subunits) and of GABAC receptors at μM concentrations. Allopregnanolone displays effects similar to other GABAA receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.
Uses
(3α)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3α)-Allopregnanolone is a metabolite of Progesterone (P755900). (3α)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain.
Definition
ChEBI: Brexanolone is a 3-hydroxy-5alpha-pregnan-20-one in which the hydroxy group at position 3 has alpha-configuration. It is a metabolite of the sex hormone progesterone and used for the treatment of postpartum depression in women. It has a role as a human metabolite, an antidepressant, a GABA modulator, an intravenous anaesthetic and a sedative.
Biological Activity
GABA A receptor positive allosteric modulator. Neuroactive steroid.
storage
Room temperature
References
1) Belelli and Lambert (2005),?Neurosteroids: endogenous regulators of the GABA(A) receptor; Nat. Rev. Neurosci,,?6?565 2) Reddy?et al. (2010),?Neurosteroids: endogenous role in the human brain and therapeutic potentials; Prog. Brain Res.,?186?113 3) Frieder?et al. (2019),?Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development; CNS Drugs,?33?265 4) Balan?et al.?(2019),?Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Proinflammatory Signaling in Macrophages and Brain; Sci. Rep.,?9?1220 5) Chang?et al.?(2019),?Neurosteroid allopregnanolone inhibits glutamate release from rat cerebrocortical nerve terminals; Synapse,?73?e22076 6) Cho?et al.?(2018),?Increased Superoxide Dismutase 2 by Allopregnanolone Ameliorates ROS-Mediated Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus; Neurochem. Res.,?43?1464
Allopregnanolone Preparation Products And Raw materials
Raw materials
Preparation Products
Allopregnanolone Suppliers
- Tel
- --
- Fax
- --
- synthesis@bujno.com.pl
- Country
- Poland
- ProdList
- 264
- Advantage
- 38
View Lastest Price from Allopregnanolone manufacturers
- Product
- ALLOPREGNAN-3ALPHA-OL-20-ONE 516-54-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 99%-101%
- Supply Ability
- 10KG
- Release date
- 2021-06-09
- Product
- 5alpha-Pregnan-3alpha-ol-20-one 516-54-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98% HPLC
- Supply Ability
- 1kg
- Release date
- 2023-08-03
- Product
- ALLOPREGNAN-3ALPHA-OL-20-ONE 516-54-1
- Price
- US $15.00/g
- Min. Order
- 100g/Bag
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2021-06-04