ChemicalBook > CAS DataBase List > N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN

N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN

Product Name
N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN
CAS No.
216758-20-2
Chemical Name
N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN
Synonyms
AMP-DNM;AMP-DEOXYNOJIRIMYCIN;ADAMANTANE-PENTYL-DNM;AMP-Deoxynojirimycin Exclusive;AMPDeoxynojirimycin,AMP Deoxynojirimycin;AMP-Deoxynojirimycin - Solution in ethanol;N-(5-AdaMant-1-yl-Methoxy)pentyl DeoxynojiriMycin;N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN;2R-(HYDROXYMETHYL)-1-[5-(TRICYCLO[3.3.2.13,7]DEC-1-YLMETHOXY)PENTYL]-3R,4R,5S-PIPERIDINETRIOL;3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-[5-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)pentyl]-, (2R,3R,4R,5S)-
CBNumber
CB5427703
Molecular Formula
C22H39NO5
Formula Weight
397.55
MOL File
216758-20-2.mol
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N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN Property

Boiling point:
569.9±50.0 °C(Predicted)
Density 
1.214±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form 
powder
pka
13.72±0.70(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10010332
Product name
AMP-Deoxynojirimycin
Purity
≥95%
Packaging
500μg
Price
$43
Updated
2024/03/01
Cayman Chemical
Product number
10010332
Product name
AMP-Deoxynojirimycin
Purity
≥95%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
10010332
Product name
AMP-Deoxynojirimycin
Purity
≥95%
Packaging
5mg
Price
$332
Updated
2024/03/01
Cayman Chemical
Product number
10010332
Product name
AMP-Deoxynojirimycin
Purity
≥95%
Packaging
10mg
Price
$579
Updated
2024/03/01
Usbiological
Product number
292616
Product name
AMP-Deoxynojirimycin
Packaging
5mg
Price
$1090
Updated
2021/12/16
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N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN Chemical Properties,Usage,Production

Chemical Properties

Off White Foam

Uses

A powerful inhibitor of the non-lysomal glucoceramidase at nanomolar concentrations. At these low concentrations, the lysosomal glucocerebrosidase and a-glucosidase, the glucoceramide synthetase, and the N-linked glycantrimming a-glucosidases of the endoplasmic reticulum are not affected.

Biological Activity

AMP-deoxynojirimycin (AMP-DNM) is an orally available iminosugar th at acts as a reversible, potent and selective inhibitor against the non-lysosomal glucosylceramidase GBA2 (IC50 = 1.7 nM) over the glucosylceramide synthase (GCS, UGCG), ER alpha-glucosidases, the lysosomal glucocerebrosidase GBA (IC50 = 0.16 μM) and alpha-glucosidase GAA (IC50 = 0.87 μM). AMP-DNM selectively inhibits cellular GBA2 in cultures (GBA2/GBA IC50 = 0.3 nM/100 nM; human melanoma cells) and exhibits in vivo therapeutic efficacy in murine models of obesity (100 mg/kg/day p.o.) and colitis (10-50 mg/kg/day via i.p. or 1.25-6.25g/kg chow).

N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN Suppliers

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216758-20-2, N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCINRelated Search:


  • N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN
  • 2R-(HYDROXYMETHYL)-1-[5-(TRICYCLO[3.3.2.13,7]DEC-1-YLMETHOXY)PENTYL]-3R,4R,5S-PIPERIDINETRIOL
  • ADAMANTANE-PENTYL-DNM
  • AMP-DEOXYNOJIRIMYCIN
  • N-(5-AdaMant-1-yl-Methoxy)pentyl DeoxynojiriMycin
  • AMP-Deoxynojirimycin - Solution in ethanol
  • AMP-Deoxynojirimycin Exclusive
  • 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-[5-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)pentyl]-, (2R,3R,4R,5S)-
  • AMPDeoxynojirimycin,AMP Deoxynojirimycin
  • AMP-DNM
  • 216758-20-2
  • Amines, Carbohydrates & Derivatives, Inhibitors