ChemicalBook > CAS DataBase List > N-BUTYLDEOXYNOJIRIMYCIN

N-BUTYLDEOXYNOJIRIMYCIN

Product Name
N-BUTYLDEOXYNOJIRIMYCIN
CAS No.
72599-27-0
Chemical Name
N-BUTYLDEOXYNOJIRIMYCIN
Synonyms
nb-dnj;OGT 918;Zavesca;megasat;SC-48334;Mg gross;miglusta;N-Butylmoranoline;N-BUTYLDEOXYNOJIRIMYCIN;N-BUTYL-1-DEOXYNOJIRIMYCIN
CBNumber
CB0125257
Molecular Formula
C10H21NO4
Formula Weight
219.28
MOL File
72599-27-0.mol
More
Less

N-BUTYLDEOXYNOJIRIMYCIN Property

Melting point:
126-127℃
alpha 
D25 -15.9° (c = 0.77 in water)
Boiling point:
394.7±42.0 °C(Predicted)
Density 
1.234
RTECS 
TN4350150
storage temp. 
2-8°C
solubility 
DMSO 44 mg/mL (200.66 mM) Ethanol 22 mg/mL (100.33 mM) Water 44 mg/mL (200.66 mM)
pka
13.72±0.70(Predicted)
form 
Powder
color 
White
Water Solubility 
Soluble in water at 10mg/ml
InChIKey
UQRORFVVSGFNRO-UTINFBMNSA-N
More
Less

Safety

WGK Germany 
3
HS Code 
2933399990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B8299
Product name
N-Butyldeoxynojirimycin
Purity
film (dried in situ)
Packaging
1mg
Price
$431
Updated
2024/03/01
Sigma-Aldrich
Product number
203996
Product name
N-Butyldeoxynojirimycin, Hydrochloride
Packaging
10mg
Price
$335
Updated
2022/05/15
Alfa Aesar
Product number
J66613
Product name
N-Butyldeoxynojirimycin, 98%
Packaging
5mg
Price
$431.65
Updated
2024/03/01
Alfa Aesar
Product number
J66613
Product name
N-Butyldeoxynojirimycin, 98%
Packaging
1mg
Price
$135
Updated
2023/06/20
Sigma-Aldrich
Product number
B8299
Product name
N-Butyldeoxynojirimycin
Purity
film (dried in situ)
Packaging
5mg
Price
$1600
Updated
2024/03/01
More
Less

N-BUTYLDEOXYNOJIRIMYCIN Chemical Properties,Usage,Production

Description

Miglustat is an N-alkylated iminosugar, launched as an oral treatment for mild to moderate type 1 Gaucher’s disease in adult patients for whom enzyme replacement therapy is not a therapeutic option. It is readily synthesized from D-glucose in three steps by first converting to N-butylglucamine via reductive amination with butylamine, followed by a microbial oxidation to an aminofuranose intermediate and subsequent reductive cyclization. Type 1 Gaucher’s disease is a metabolic disorder caused by the lysosomal accumulation of certain glycosphingolipids (GSLs) as a result of deficiency in their degradation. Enlargement of the liver and spleen, low blood platelet and bone lesions are among the key symptoms of this disease. Miglustat acts by inhibiting glucosylceramide synthase, a glucosyl transferase enzyme in the biosynthesis of most GSLs, which results in the lowering of GSLs to a level that can be effectively cleared. Up to 50% reduction in liver and splenocyte GSL levels are achieved in mice by long-term administration of Miglustat (600– 1800 mg/kg/day for 118 days). Miglustat, dosed at 50 and 100 mg in Gaucher patients, exhibits dose proportionate pharmacokinetics (tmax=2.5 h, t1/2=6 to 7 h) and ＞90% oral bioavailability. Steady-state plasma levels are reached after 4–6 weeks of treatment. Miglustat is not significantly metabolized in humans and the major route of excretion is renal. In clinical trials, efficacy was demonstrated by significant reductions in liver and spleen volumes (12 and 19%, respectively) at 12 months and increase in hemoglobin and platelet count (0.91 g/dL and 13.6×109/l, respectively) at 24 months. Miglustat is generally well tolerated by patients and the most common side effects are diarrhea and weight loss.

Originator

G.D. Searle (Pfizer) (US)

Uses

An alpha-glucosidase Inhibitor

Uses

Treatment of glycolipid storage diseases.

Definition

ChEBI: A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group.

brand name

Zavesca(Actelion);Vevesca.

General Description

N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.

Biological Activity

Orally active α -glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CTFR in human airway epithelial cells via inhibition of ER α -glucosidases I and II. Also has broad spectrum antiviral activity.

Biochem/physiol Actions

N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.

N-BUTYLDEOXYNOJIRIMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-BUTYLDEOXYNOJIRIMYCIN Suppliers

China 106 Germany 1 India 7 Japan 1 Switzerland 1 United Kingdom 3 United States 13 Global 132
Chemleader Biomedical Co., Limited.
Tel
021-58180488
Fax
021-58180499
Email
sales@MedChemLeader.com
Country
China
ProdList
999
Advantage
58
Hengyang Jiaxuan Biotechnology Co. LTD
Tel
18684598761
Fax
QQ：675042965
Email
675042965@qq.com
Country
China
ProdList
308
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
Country
China
ProdList
371
Advantage
57
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
Shanghai Hanhong Scientific Co.,Ltd.
Tel
Country
China
ProdList
42982
Advantage
64
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25014
Advantage
65
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
More
Less

View Lastest Price from N-BUTYLDEOXYNOJIRIMYCIN manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
N-BUTYLDEOXYNOJIRIMYCIN 72599-27-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-30
Hebei Guanlang Biotechnology Co., Ltd.
Product
N-BUTYLDEOXYNOJIRIMYCIN 72599-27-0
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-06-21
Handan Tongyi New Material Technology Co., Ltd
Product
Hot Sale 3, 4, 5-Piperidinetriol, 1-Butyl-2- (hydroxymethyl) -, (2R, 3R, 4R, 5S) N-BUTYLDEOXYNOJIRIMYCIN 72599-27-0
Price
US $1.00/g
Min. Order
1KG
Purity
99.9
Supply Ability
70000
Release date
2021-02-25

72599-27-0, N-BUTYLDEOXYNOJIRIMYCINRelated Search:

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Deionized water Cocamidopropyl betaine 1-Deoxynojirimycin N-Dodecyldeoxynojirimycin N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN N-(7-Oxa-9,9,9-trifluorononyl)deoxynojirimycin N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN, HYDROCHLORIDE N-(7-Oxadecyl)deoxynojirimycin CAMIGLIBOSE N-5-Carboxypentyl-1-deoxynojirimycin N-(n-Nonyl)deoxynojirimycin N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE glycovir N-BUTYLDEOXYNOJIRIMYCIN

  • N-Butyldeoxynojirimycin, Hydrochloride - CAS 72599-27-0 - Calbiochem
  • Mg gross
  • N-BUTYLDEOXYNOJIRIMYCIN;SC-48334;NB-DNJ;OGT-918
  • N-BUTYLDEOXYNOJIRIMYCIN
  • N-BUTYL-1-DEOXYNOJIRIMYCIN
  • (2R)-1-Butyl-2α-(hydroxymethyl)piperidine-3β,4α,5β-triol
  • 1,5-(Butylimino)-1,5-dideoxy-D-glucitol
  • 1-Butyl-2α-(hydroxymethyl)piperidine-3β,4α,5β-triol
  • 1-Butyl-3β,4α,5β-trihydroxypiperidine-2α-methanol
  • SC-48334
  • (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol
  • N-Butylmoranoline
  • OGT 918
  • Zavesca
  • nb-dnj
  • Miglustat, NB-DNJ, (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
  • N-(n-Butyl)-1-deoxynojirimycin min. 99%
  • MIGLUSTAT;N-BUTYLDEOXYNOJIRIMYCIN;NB-DNJ;OGT918
  • Miglustat (N-Butyldeoxynojirimycin)
  • N-(n-Butyl)-1-deoxynojirimycin
  • 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, (2R,3R,4R,5S)-
  • Hot Sale 3, 4, 5-Piperidinetriol, 1-Butyl-2- (hydroxymethyl) -, (2R, 3R, 4R, 5S) N-BUTYLDEOXYNOJIRIMYCIN
  • Miglustat hydrochloride salt
  • MiglustatQ: What is Miglustat Q: What is the CAS Number of Miglustat Q: What is the storage condition of Miglustat
  • oral,Miglustat,Inhibitor,inhibit,ceramide glucosyltransferase,OGT-918,OGT 918,type I gaucher disease
  • miglusta
  • megasat
  • 72599-27-0
  • C10H22NO4
  • Glucosidase, alpha-
  • D to K
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • Biochemicals and Reagents
  • BioChemical
  • API