N-BUTYLDEOXYNOJIRIMYCIN

ChemicalBook > CAS DataBase List > N-BUTYLDEOXYNOJIRIMYCIN

N-BUTYLDEOXYNOJIRIMYCIN

Product Name: N-BUTYLDEOXYNOJIRIMYCIN
CAS No.: 72599-27-0
Chemical Name: N-BUTYLDEOXYNOJIRIMYCIN
Synonyms: nb-dnj;OGT 918;Zavesca;megasat;SC-48334;Mg gross;miglusta;N-Butylmoranoline;N-BUTYLDEOXYNOJIRIMYCIN;N-BUTYL-1-DEOXYNOJIRIMYCIN
CBNumber: CB0125257
Molecular Formula: C10H21NO4
Formula Weight: 219.28
MOL File: 72599-27-0.mol

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N-BUTYLDEOXYNOJIRIMYCIN Property

Melting point:: 126-127℃
alpha: D25 -15.9° (c = 0.77 in water)
Boiling point:: 394.7±42.0 °C(Predicted)
Density: 1.234
RTECS: TN4350150
storage temp.: 2-8°C
solubility: DMSO 44 mg/mL (200.66 mM) Ethanol 22 mg/mL (100.33 mM) Water 44 mg/mL (200.66 mM)
pka: 13.72±0.70(Predicted)
form: Powder
color: White
Water Solubility: Soluble in water at 10mg/ml
InChIKey: UQRORFVVSGFNRO-UTINFBMNSA-N

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Safety

WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B8299
Product name: N-Butyldeoxynojirimycin
Purity: film (dried in situ)
Packaging: 1mg
Price: $431
Updated: 2024/03/01

Sigma-Aldrich

Product number: 203996
Product name: N-Butyldeoxynojirimycin, Hydrochloride
Packaging: 10mg
Price: $335
Updated: 2022/05/15

Alfa Aesar

Product number: J66613
Product name: N-Butyldeoxynojirimycin, 98%
Packaging: 5mg
Price: $431.65
Updated: 2024/03/01

Alfa Aesar

Product number: J66613
Product name: N-Butyldeoxynojirimycin, 98%
Packaging: 1mg
Price: $135
Updated: 2023/06/20

Sigma-Aldrich

Product number: B8299
Product name: N-Butyldeoxynojirimycin
Purity: film (dried in situ)
Packaging: 5mg
Price: $1600
Updated: 2024/03/01

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N-BUTYLDEOXYNOJIRIMYCIN Chemical Properties,Usage,Production

Description

Miglustat is an N-alkylated iminosugar, launched as an oral treatment for mild to moderate type 1 Gaucher’s disease in adult patients for whom enzyme replacement therapy is not a therapeutic option. It is readily synthesized from D-glucose in three steps by first converting to N-butylglucamine via reductive amination with butylamine, followed by a microbial oxidation to an aminofuranose intermediate and subsequent reductive cyclization. Type 1 Gaucher’s disease is a metabolic disorder caused by the lysosomal accumulation of certain glycosphingolipids (GSLs) as a result of deficiency in their degradation. Enlargement of the liver and spleen, low blood platelet and bone lesions are among the key symptoms of this disease. Miglustat acts by inhibiting glucosylceramide synthase, a glucosyl transferase enzyme in the biosynthesis of most GSLs, which results in the lowering of GSLs to a level that can be effectively cleared. Up to 50% reduction in liver and splenocyte GSL levels are achieved in mice by long-term administration of Miglustat (600– 1800 mg/kg/day for 118 days). Miglustat, dosed at 50 and 100 mg in Gaucher patients, exhibits dose proportionate pharmacokinetics (t_max=2.5 h, t_1/2=6 to 7 h) and ＞90% oral bioavailability. Steady-state plasma levels are reached after 4–6 weeks of treatment. Miglustat is not significantly metabolized in humans and the major route of excretion is renal. In clinical trials, efficacy was demonstrated by significant reductions in liver and spleen volumes (12 and 19%, respectively) at 12 months and increase in hemoglobin and platelet count (0.91 g/dL and 13.6×10⁹/l, respectively) at 24 months. Miglustat is generally well tolerated by patients and the most common side effects are diarrhea and weight loss.

Originator

G.D. Searle (Pfizer) (US)

Uses

An alpha-glucosidase Inhibitor

Uses

Treatment of glycolipid storage diseases.

Definition

ChEBI: A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group.

brand name

Zavesca(Actelion);Vevesca.

General Description

N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.

Biological Activity

Orally active α -glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CTFR in human airway epithelial cells via inhibition of ER α -glucosidases I and II. Also has broad spectrum antiviral activity.

Biochem/physiol Actions

N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.

N-BUTYLDEOXYNOJIRIMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-BUTYLDEOXYNOJIRIMYCIN manufacturers

Hebei Guanlang Biotechnology Co., Ltd.

Product: N-BUTYLDEOXYNOJIRIMYCIN 72599-27-0
Price: US $1.00/PCS
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-06-21

Hebei Duling International Trade Co. LTD

Product: N-BUTYLDEOXYNOJIRIMYCIN 72599-27-0
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-05-21

Hebei Mojin Biotechnology Co., Ltd

Product: N-BUTYLDEOXYNOJIRIMYCIN 72599-27-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-06-30

72599-27-0, N-BUTYLDEOXYNOJIRIMYCINRelated Search:

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Deionized water Cocamidopropyl betaine 1-Deoxynojirimycin N-Dodecyldeoxynojirimycin N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN N-(7-Oxa-9,9,9-trifluorononyl)deoxynojirimycin N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN, HYDROCHLORIDE N-(7-Oxadecyl)deoxynojirimycin CAMIGLIBOSE N-5-Carboxypentyl-1-deoxynojirimycin N-(n-Nonyl)deoxynojirimycin N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE glycovir N-BUTYLDEOXYNOJIRIMYCIN

N-Butyldeoxynojirimycin, Hydrochloride - CAS 72599-27-0 - Calbiochem

Mg gross

N-BUTYLDEOXYNOJIRIMYCIN;SC-48334;NB-DNJ;OGT-918

N-BUTYLDEOXYNOJIRIMYCIN

N-BUTYL-1-DEOXYNOJIRIMYCIN

(2R)-1-Butyl-2α-(hydroxymethyl)piperidine-3β,4α,5β-triol

1,5-(Butylimino)-1,5-dideoxy-D-glucitol

1-Butyl-2α-(hydroxymethyl)piperidine-3β,4α,5β-triol

1-Butyl-3β,4α,5β-trihydroxypiperidine-2α-methanol

SC-48334

(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol

N-Butylmoranoline

OGT 918

Zavesca

nb-dnj

Miglustat, NB-DNJ, (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

N-(n-Butyl)-1-deoxynojirimycin min. 99%

MIGLUSTAT;N-BUTYLDEOXYNOJIRIMYCIN;NB-DNJ;OGT918

Miglustat (N-Butyldeoxynojirimycin)

N-(n-Butyl)-1-deoxynojirimycin

3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, (2R,3R,4R,5S)-

Hot Sale 3, 4, 5-Piperidinetriol, 1-Butyl-2- (hydroxymethyl) -, (2R, 3R, 4R, 5S) N-BUTYLDEOXYNOJIRIMYCIN

Miglustat hydrochloride salt

MiglustatQ: What is Miglustat Q: What is the CAS Number of Miglustat Q: What is the storage condition of Miglustat

oral,Miglustat,Inhibitor,inhibit,ceramide glucosyltransferase,OGT-918,OGT 918,type I gaucher disease

miglusta

megasat

72599-27-0

C10H22NO4

Glucosidase, alpha-

D to K

Enzyme Inhibitors

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Biochemicals and Reagents

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