N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE

Product Name: N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
CAS No.: 210110-90-0
Chemical Name: N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
Synonyms: NB-DNJ, HCL;Miglustat HCl;(2R,3R,4R,5S)-;N-BUTYL-DNJ, HCL;NB-DNJ hydrochloride;OGT918 hydrochloride;Zavesca hydrochloride;Miglustat HCl (OGT-918;Miglustat, Hydrochloride;N-BUTYLDEOXYNOJIRIMYCIN HCL
CBNumber: CB7328886
Molecular Formula: C10H22ClNO4
Formula Weight: 255.74
MOL File: 210110-90-0.mol

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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Property

Melting point:: 169-172°C
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
form: White to off-white solid.
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

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Safety

Hazard Codes: Xi
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $353
Updated: 2024/03/01

Tocris

Product number: 3117
Product name: Miglustathydrochloride
Packaging: 10
Price: $227
Updated: 2021/12/16

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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Miglustat HCl (210110-90-0) is an orally active ceramide-specific glycosyltransferase and α-glucosidase I and II inhibitor.1 Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II.2 Pharmacological chaperone for glucocerebrosidase degradation.3 Clinically useful agent for Gaucher disease type 1.4 Stabilizes neurological disorders in Niemann-Pick disease type C.5

Chemical Properties

White Crystals

Uses

An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. N-Butyldeoxynojirimycin has recently been used to retard lipid storage in the central nervous system of an animal m odel of Tay-Sachs disease. 1-Deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.

in vivo

Miglustat (0.2?mg/kg; oral administration; once) hydrochloride is able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability^[2].

Animal Model:	NPC1?/? mice^[1]
Dosage:	0.2?mg/kg
Administration:	Oral administration; once
Result:	Was able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability.

storage

Desiccate at -20°C

References

[1] F. PLATT. N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.[J]. The Journal of Biological Chemistry, 1994, 106 1: 8362-8365. DOI:10.1016/s0021-9258(17)37202-2
[2] SABRINA NOËL. Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.[J]. Journal of Pharmacology and Experimental Therapeutics, 2008, 325 3: 1016-1023. DOI:10.1124/jpet.107.135582
[3] OLGA ABIAN*. Therapeutic Strategies for Gaucher Disease: Miglustat (NB-DNJ) as a Pharmacological Chaperone for Glucocerebrosidase and the Different Thermostability of Velaglucerase Alfa and Imiglucerase[J]. Molecular Pharmaceutics, 2011, 8 6: 2390-2397. DOI:10.1021/mp200313e
[4] CHRISTINE SERRATRICE Jacques S Laure Swiader. Switching from imiglucerase to miglustat for the treatment of French patients with Gaucher disease type 1: a case series.[J]. Journal of Medical Case Reports, 2015, 9: 146. DOI:10.1186/s13256-015-0617-5
[5] PARVANEH KARIMZADEH. Effects of miglustat on stabilization of neurological disorder in niemann-pick disease type C: Iranian pediatric case series.[J]. Journal of Child Neurology, 2013, 28 12: 1599-1606. DOI:10.1177/0883073812464526

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Suppliers

Canada 1 China 75 Germany 1 United Kingdom 5 United States 15 Global 97

J & K SCIENTIFIC LTD.

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210110-90-0, N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDERelated Search:

Nafamostat mesylate Ketoconazole Zafirlukast Vorinostat Sulfanilamide (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Deoxynojirimycin hydrochloride 2,2'-(Butylimino)diethanol N-METHYL-1-DEOXYNOJIRIMYCIN 1-Deoxynojirimycin (R)-3-Hydroxypiperidine hydrocloride N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN, HYDROCHLORIDE N-BUTYLDEOXYNOJIRIMYCIN N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE trans-3,4-Dihydroxypiperidine 1,5-DIDEOXY-1,5-IMINO-XYLITOL N-Dodecyldeoxynojirimycin

Miglustat, Hydrochloride

(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-,3,4,5-Piperidinetriol Hydrochloride

N-BUTYLDEOXYNOJIRIMYCIN HCL

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE

N-BUTYL-DNJ, HCL

NB-DNJ, HCL

N-(N-BUTYL)DEOXYNOJIRIMYCIN, HYDROCHLORIDE

(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride

Miglustat hydrochloride, N-(n-Butyl)deoxynojirimycin hydrochloride

(2R,3R,4R,5S)-

Miglustat HCl, NB-DNJ HCl, (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

N-(n-Butyl)-1-deoxynojirimycin hydrochloride min. 99%

Miglustat HCl

(2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

NB-DNJ hydrochloride

N-BUTYLDEOXYNOJIRIMYCIN; HYDROCHLORIDE;NB-DNJ HYDROCHLORIDE;OGT918 HYDROCHLORIDE;ZAVESCA HYDROCHLORIDE

OGT918 hydrochloride

Zavesca hydrochloride

N-(n-Butyl)-1-deoxynojirimycin hydrochloride

Miglustat hydrochloride(N-Butyldeoxynojirimycin, Hydrochloride)

Miglustat HCl (OGT-918

N-Butyldeoxynojirimycin,OGT-918,type I gaucher disease,Miglustat,Miglustat hydrochloride,oral,Glucosylceramide Synthase (GCS),OGT918,ceramide glucosyltransferase,NB-DNJ,Inhibitor,inhibit,OGT 918

Miglustat hydrochloride, 10 mM in DMSO

210110-90-0

C10H21NO4HCl

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