Deoxynojirimycin hydrochloride

Product Name: Deoxynojirimycin hydrochloride
CAS No.: 73285-50-4
Chemical Name: Deoxynojirimycin hydrochloride
Synonyms: DNJ;DNM;DNM1;1-DNJ;AT 2220;DNJ, HCL;B-dynamin;DEOXYNOJIRIMYCIN;DEOXYNOJIRIMICIN;Dynamin BREDNM19
CBNumber: CB2128151
Molecular Formula: C6H13NO4.ClH
Formula Weight: 199.63
MOL File: 73285-50-4.mol

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Deoxynojirimycin hydrochloride Property

Melting point:: 195-196°C
storage temp.: Inert atmosphere,2-8°C
solubility: Water (Slightly)
form: Powder
color: White
Water Solubility: Soluble in water at 20mg/ml
BRN: 3563225
Stability:: Hygroscopic
InChI: InChI=1/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/s3
InChIKey: ZJIHMALTJRDNQI-KOVNLEGCNA-N
SMILES: C([C@H]1NC[C@@H]([C@H]([C@@H]1O)O)O)O.Cl |&1:1,4,5,6,r|
CAS DataBase Reference: 73285-50-4

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Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26-36-24/25-22
WGK Germany: 3
F: 10

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D9305
Product name: 1-Deoxynojirimycin hydrochloride
Packaging: 5mg
Price: $260
Updated: 2025/07/31

Cayman Chemical

Product number: 10011718
Product name: 1-Deoxynojirimycin (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 10011718
Product name: 1-Deoxynojirimycin (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 10011718
Product name: 1-Deoxynojirimycin (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $23
Updated: 2021/12/16

Sigma-Aldrich

Product number: D9305
Product name: 1-Deoxynojirimycin hydrochloride
Packaging: 10mg
Price: $370
Updated: 2025/07/31

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Deoxynojirimycin hydrochloride Chemical Properties,Usage,Production

Description

1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in M. alba (mulberry) leaves and has diverse biological activities. It inhibits the activities of α- and β-glucosidase (IC₅₀s = 35 and 71 μM, respectively). 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells. It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM. 1-DNJ (1-100 μg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells. It improves glucose and insulin tolerance in db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks.

Chemical Properties

White Crystalline Solid

Uses

natural chitin synthase inhibitor

General Description

Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc₃Man₉GlcNAc₂ in N-linked glycan biosynthesis.

Biochem/physiol Actions

Product does not compete with ATP.

References

[1] KUO GAO. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing.[J]. Molecules, 2016, 21 1. DOI: 10.3390/molecules21111600
[2] ANA I AHUJA-CASARíN. Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors.[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021: 138-146. DOI: 10.1080/14756366.2020.1847101
[3] JULIAN A. CODELLI. Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry[J]. Journal of the American Chemical Society, 2008, 130 34: 11486-11493. DOI: 10.1021/ja803086r
[4] MARIE-JEANNE PAPANDRéOU. The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step.[J]. Molecular Pharmacology, 2002, 61 1 1: 186-193. DOI: 10.1124/mol.61.1.186
[5] RAN-JUH WANG Miao L H Chun Hung Yang. 1-Deoxynojirimycin Inhibits Metastasis of B16F10 Melanoma Cells by Attenuating the Activity and Expression of Matrix Metalloproteinases-2 and -9 and Altering Cell Surface Glycosylation[J]. Journal of Agricultural and Food Chemistry, 2010, 58 16: 8988-8993. DOI: 10.1021/jf101401b
[6] QINGPU LIU. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice.[J]. Molecules, 2015, 20 1: 21700-21714. DOI: 10.3390/molecules201219794

Deoxynojirimycin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Deoxynojirimycin hydrochloride Suppliers

Canada 1 China 143 Europe 2 Germany 3 India 3 Italy 1 Japan 1 New Zealand 1 Switzerland 4 United Kingdom 7 United States 27 USA 1 Global 194

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View Lastest Price from Deoxynojirimycin hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Deoxynojirimycin hydrochloride 73285-50-4
Price: US $0.00/G
Min. Order: 10G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-15

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Deoxynojirimycin hydrochloride; DNJ 73285-50-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: ≥98% HPLC
Supply Ability: 1000KG
Release date: 2022-09-20

Career Henan Chemical Co

Product: Deoxynojirimycin hydrochloride 73285-50-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-07

73285-50-4, Deoxynojirimycin hydrochlorideRelated Search:

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73285-50-4

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