Nafamostat mesylate
- Product Name
- Nafamostat mesylate
- CAS No.
- 82956-11-4
- Chemical Name
- Nafamostat mesylate
- Synonyms
- FUTHAN;FUT-175;CS-128;Coahibitor;nafamstatmesilate;Nafamostat mesila;Nafomastatmesilate;Nafamstat mesylate;Nafmostat mesylate;NAFAMOSTAT MESYLATE
- CBNumber
- CB9764794
- Molecular Formula
- C21H25N5O8S2
- Formula Weight
- 539.58
- MOL File
- 82956-11-4.mol
Nafamostat mesylate Property
- Melting point:
- 259-261°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in Water (up to 25 mg/ml).
- form
- powder
- color
- white to beige
- Merck
- 14,6350
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at 4°C for up to 1 month, or at -80°C for up to 6 months.
- InChI
- InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)
- InChIKey
- SRXKIZXIRHMPFW-UHFFFAOYSA-N
- SMILES
- CS(O)(=O)=O.CS(O)(=O)=O.C(OC1=CC=C2C(=C1)C=CC(C(=N)N)=C2)(=O)C1=CC=C(NC(N)=N)C=C1
- CAS DataBase Reference
- 82956-11-4(CAS DataBase Reference)
Safety
- RIDADR
- 3077
- WGK Germany
- nwg
- RTECS
- DG2736000
- HS Code
- 29252900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- N0289
- Product name
- Nafamostat mesylate
- Purity
- ≥98% (HPLC)
- Packaging
- 10MG
- Price
- $156
- Updated
- 2024/03/01
- Product number
- N0289
- Product name
- Nafamostat mesylate
- Purity
- ≥98% (HPLC)
- Packaging
- 50MG
- Price
- $613
- Updated
- 2024/03/01
- Product number
- N0959
- Product name
- Nafamostat Mesylate
- Purity
- >98.0%(HPLC)
- Packaging
- 20mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- N0959
- Product name
- Nafamostat Mesylate
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $239
- Updated
- 2024/03/01
- Product number
- 14837
- Product name
- Nafamostat (mesylate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
Nafamostat mesylate Chemical Properties,Usage,Production
Description
Nafamostat mesylate is a protease inhibitor useful in the treatment of acute pancreatitis. It has anticomplement, anticoagulant, antikallikrein and other activities, and thus may have additional utility in the treatment of autoimmune diseases and disseminated intravascular coagulation.
Chemical Properties
Tan to pale orange solid
Originator
Torii (Japan)
Uses
A non-peptide proteaseinhibitor.
Uses
Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma
brand name
FUTHAN
Biological Activity
Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
Biochem/physiol Actions
Nafamostat mesylate is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor.
Synthesis
By p-guanidinobenzoic acid hydrochloride, 6-amidino groups-beta naphthal, 4,5-dicyano imidazole, methylene dichloride mix, 0-5 ℃ is stirred 1 hour, then improve temperature to 18-22 ℃, insulation reaction 8-12h, filters washed with dichloromethane, gained solid is 2 with methylsulfonic acid adjust pH, obtains nafamostat mesylate.
storage
Store at +4°C
References
1) Han et al. (2019) Identification of nafamostat mesilate as an inhibitor of the fat mass and obesity-associated protein (FTO) demethylase; Chem. Biol. Interact., 297 80
Nafamostat mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Nafamostat mesylate manufacturers
- Product
- nafamostat mesilate 82956-11-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-10
- Product
- Nafamostat Mesylate 82956-11-4
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-04-01
- Product
- Nafamostat mesylate 82956-11-4
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98.5～101.5%
- Supply Ability
- 10kg/month
- Release date
- 2021-06-17