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Nafamostat mesylate

Product Name
Nafamostat mesylate
CAS No.
82956-11-4
Chemical Name
Nafamostat mesylate
Synonyms
FUTHAN;FUT-175;CS-128;Coahibitor;nafamstatmesilate;Nafamostat mesila;Nafomastatmesilate;Nafamstat mesylate;Nafmostat mesylate;NAFAMOSTAT MESYLATE
CBNumber
CB9764794
Molecular Formula
C21H25N5O8S2
Formula Weight
539.58
MOL File
82956-11-4.mol
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Nafamostat mesylate Property

Melting point:
259-261°C
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in Water (up to 25 mg/ml).
form 
powder
color 
white to beige
Merck 
14,6350
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at 4°C for up to 1 month, or at -80°C for up to 6 months.
InChI
InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)
InChIKey
SRXKIZXIRHMPFW-UHFFFAOYSA-N
SMILES
CS(O)(=O)=O.CS(O)(=O)=O.C(OC1=CC=C2C(=C1)C=CC(C(=N)N)=C2)(=O)C1=CC=C(NC(N)=N)C=C1
CAS DataBase Reference
82956-11-4(CAS DataBase Reference)
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Safety

RIDADR 
3077
WGK Germany 
nwg
RTECS 
DG2736000
HS Code 
29252900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N0289
Product name
Nafamostat mesylate
Purity
≥98% (HPLC)
Packaging
10MG
Price
$156
Updated
2024/03/01
Sigma-Aldrich
Product number
N0289
Product name
Nafamostat mesylate
Purity
≥98% (HPLC)
Packaging
50MG
Price
$613
Updated
2024/03/01
TCI Chemical
Product number
N0959
Product name
Nafamostat Mesylate
Purity
>98.0%(HPLC)
Packaging
20mg
Price
$72
Updated
2024/03/01
TCI Chemical
Product number
N0959
Product name
Nafamostat Mesylate
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$239
Updated
2024/03/01
Cayman Chemical
Product number
14837
Product name
Nafamostat (mesylate)
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
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Nafamostat mesylate Chemical Properties,Usage,Production

Description

Nafamostat mesylate is a protease inhibitor useful in the treatment of acute pancreatitis. It has anticomplement, anticoagulant, antikallikrein and other activities, and thus may have additional utility in the treatment of autoimmune diseases and disseminated intravascular coagulation.

Chemical Properties

Tan to pale orange solid

Originator

Torii (Japan)

Uses

A non-peptide proteaseinhibitor.

Uses

Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma

brand name

FUTHAN

Biological Activity

Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.

Biochem/physiol Actions

Nafamostat mesylate is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor.

Synthesis

By p-guanidinobenzoic acid hydrochloride, 6-amidino groups-beta naphthal, 4,5-dicyano imidazole, methylene dichloride mix, 0-5 ℃ is stirred 1 hour, then improve temperature to 18-22 ℃, insulation reaction 8-12h, filters washed with dichloromethane, gained solid is 2 with methylsulfonic acid adjust pH, obtains nafamostat mesylate.

storage

Store at +4°C

References

1) Han et al. (2019) Identification of nafamostat mesilate as an inhibitor of the fat mass and obesity-associated protein (FTO) demethylase; Chem. Biol. Interact., 297 80

Nafamostat mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nafamostat mesylate manufacturers

airuikechemical co., ltd.
Product
nafamostat mesilate 82956-11-4
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-10
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Nafamostat Mesylate 82956-11-4
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-01
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Nafamostat mesylate 82956-11-4
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98.5～101.5%
Supply Ability
10kg/month
Release date
2021-06-17

82956-11-4, Nafamostat mesylateRelated Search:

Denatonium Benzoate Anhydrous Pimecrolimus NAFAMOSTAT MESYLATE Betahistine mesylate Methyl benzoate p-Toluic acid 3-(Trifluoromethyl)benzoic acid Sodium benzoate 1-(1-NAPHTHYL)-2-THIOUREA m-Toluic acid Benzyl benzoate Methyl 4-methylbenzoate Emamectin benzoate Methyl 4-(bromomethyl)benzoate o-Toluic acid WIN 55,212-2 MESYLATE Gabexate mesylate Lignin Sulfonate

  • 4-((aminoiminomethyl)amino)-benzoicaci6-(aminoiminomethyl)-2-naphthalenyl
  • 6-carbaMiMidoylnaphthalen-2-yl 4-guanidinobenzoate diMethanesulfonate
  • [amino-[6-[[4-(diaminomethyleneazaniumyl)phenyl]-oxomethoxy]-2-naphthyl]methylene]ammonium
  • [amino-[6-[4-(diaminomethyleneazaniumyl)benzoyl]oxy-2-naphthyl]methylene]ammonium
  • [amino-[6-[4-(diaminomethylideneazaniumyl)benzoyl]oxynaphthalen-2-yl]methylidene]azanium
  • [amino-[6-[4-(diaminomethylideneazaniumyl)phenyl]carbonyloxynaphthalen-2-yl]methylidene]azanium
  • Nafamostat mesylate, >=98%
  • 5-methyl-1-{6-[(7-oxo-7h-furo[3,2-g]chromen-9-yl)oxy]hexyl}pyrimidine-2,4(1h,3h)-dione
  • Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate
  • 6-[amino(imino)methyl]-2-naphthyl 4-{[amino(imino)methyl]amino}benzoate dimethanesulfonate
  • ester,dimethanesulfonate
  • nafamstatmesilate
  • NAFAMOSTAT MESYLATE
  • FUT-175
  • FUTHAN
  • 6-AMIDINO-2-NAPHTHYL-4-GUANIDINOBENZOATE DIMETHANESULFONATE
  • 6-amidino-2-naphthyl 4-guanidino-benzoate dimethanesulphonate
  • 6-AMIDINO-2-NAPHTHYL-4-GUANIDINOENZOATE, MESYLATE
  • FUT-175,6-Amidino-2-naphthyl-4-guanidinoenzoate,mesylate
  • Nafomastatmesilate
  • FUT-175, 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
  • 4-Guanidinobenzoic acid 6-amidino-2-naphtyl·2(methanesulfonic acid)
  • Nafamstat mesylate
  • 4-[(Aminoiminomethyl)amino]benzoicacid6-(aminoiminomethyl)-2-naphthalenylesterdimethanesulfonate
  • NafaMostat Mesilate, NafaMostat Mesylate
  • Nafamostat mesilate C21H25N5O8S2 high quality Casnumber： 82956-11-4
  • Nafamostat mesylate, 98%, broad spectrum, potent protease inhibitor
  • NafaMostat Mesylate(FUT-175)
  • Nafamostat mesila
  • Nafamostat mesylate Manufacturer/High quality/Best price/In stock CAS NO.82956-11-4
  • CS-128
  • Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, methanesulfonate (1:2)
  • Coahibitor
  • COAHIBITOR;FUT-175;FUTHAN
  • 6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate
  • Nafamostat Mesylate &gt
  • Nafmostat mesylate
  • 4-Guanidinobenzoic Acid 6-Amidino-2-naphthyl Ester Bis(methanesulfonate)
  • 6-Amidino-2-naphthyl 4-Guanidinobenzoate Bis(methanesulfonate)
  • Nafamostat Mesylate (10mM in DMSO)
  • Supply Nafamostat Mesylate CAS: 82956-11-4
  • Nafamostat Mesylate for Treatment Pancreatitis CAS No.:?82956-11-4
  • [13C6]-Nafamostat mesylate
  • Naphthalimostat methanesulfonate
  • Nafamostat mesilate (FUT-175)
  • Naphtholimus mesylate
  • Nafamostat Mesylate CRS
  • Nafamostate Mesylate
  • 6-carbamimidoylnaphthalen-2-yl 4-guanidinobenzoate methanesulfonate
  • 82956-11-4
  • C21H25N5O8S2
  • C19H17N5O22C4O3S
  • C19H17N5O22CH4O3SC21H25N5O8S2
  • C19H17N5O22CH3SO3H
  • C19H17N5O22CH4O3S
  • Inhibitors
  • Aromatics
  • Intermediates & Fine Chemicals