ChemicalBook > CAS DataBase List > N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE

Product Name: N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
CAS No.: 210110-90-0
Chemical Name: N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
Synonyms: NB-DNJ, HCL;Miglustat HCl;(2R,3R,4R,5S)-;N-BUTYL-DNJ, HCL;NB-DNJ hydrochloride;OGT918 hydrochloride;Zavesca hydrochloride;Miglustat HCl (OGT-918;Miglustat, Hydrochloride;N-BUTYLDEOXYNOJIRIMYCIN HCL
CBNumber: CB7328886
Molecular Formula: C10H22ClNO4
Formula Weight: 255.74
MOL File: 210110-90-0.mol

Less

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Property

Melting point:: 169-172°C
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
form: White to off-white solid.
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

Less

Safety

Hazard Codes: Xi
HS Code: 2933399990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $353
Updated: 2024/03/01

Tocris

Product number: 3117
Product name: Miglustathydrochloride
Packaging: 10
Price: $227
Updated: 2021/12/16

Less

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Miglustat HCl (210110-90-0) is an orally active ceramide-specific glycosyltransferase and α-glucosidase I and II inhibitor.1 Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II.2 Pharmacological chaperone for glucocerebrosidase degradation.3 Clinically useful agent for Gaucher disease type 1.4 Stabilizes neurological disorders in Niemann-Pick disease type C.5

Chemical Properties

White Crystals

Uses

An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. N-Butyldeoxynojirimycin has recently been used to retard lipid storage in the central nervous system of an animal m odel of Tay-Sachs disease. 1-Deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.

in vivo

Miglustat (0.2?mg/kg; oral administration; once) hydrochloride is able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability^[2].

Animal Model:	NPC1?/? mice^[1]
Dosage:	0.2?mg/kg
Administration:	Oral administration; once
Result:	Was able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability.

storage

Desiccate at -20°C

References

[1] F. PLATT. N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.[J]. The Journal of Biological Chemistry, 1994, 106 1: 8362-8365. DOI:10.1016/s0021-9258(17)37202-2
[2] SABRINA NOËL. Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.[J]. Journal of Pharmacology and Experimental Therapeutics, 2008, 325 3: 1016-1023. DOI:10.1124/jpet.107.135582
[3] OLGA ABIAN*. Therapeutic Strategies for Gaucher Disease: Miglustat (NB-DNJ) as a Pharmacological Chaperone for Glucocerebrosidase and the Different Thermostability of Velaglucerase Alfa and Imiglucerase[J]. Molecular Pharmaceutics, 2011, 8 6: 2390-2397. DOI:10.1021/mp200313e
[4] CHRISTINE SERRATRICE Jacques S Laure Swiader. Switching from imiglucerase to miglustat for the treatment of French patients with Gaucher disease type 1: a case series.[J]. Journal of Medical Case Reports, 2015, 9: 146. DOI:10.1186/s13256-015-0617-5
[5] PARVANEH KARIMZADEH. Effects of miglustat on stabilization of neurological disorder in niemann-pick disease type C: Iranian pediatric case series.[J]. Journal of Child Neurology, 2013, 28 12: 1599-1606. DOI:10.1177/0883073812464526

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Suppliers

Canada 1 China 75 Germany 1 United Kingdom 5 United States 15 Global 97

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9750
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

NewCan Biotech Limited

Tel: +86-0571-86912261 +8613735419629
Email: sales@newcanbio.com
Country: China
ProdList: 9985
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15109
Advantage: 58

Hengyang Jiaxuan Biotechnology Co. LTD

Tel: 18684598761
Fax: QQ：675042965
Email: 675042965@qq.com
Country: China
ProdList: 308
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-025-85560043 17301488900
Fax: 025-85563444
Email: info@synzest.com
Country: China
ProdList: 9286
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4989
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 10784
Advantage: 58

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 2998
Advantage: 58

Hangzhou FuRun Pharmaceutical Technology Co., Ltd

Tel: 15658004993
Email: 1900830611@qq.com
Country: China
ProdList: 980
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

ChemeGen

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

Tianjin Yankai Scientific Co. Ltd.

Tel: 18500985499
Email: yankaisale@qq.com
Country: China
ProdList: 481
Advantage: 58

NewCan Biotech Limited

Tel: +86-0571-86912261 +86-15658003402
Fax: 311113
Email: sales@newcanbio.com
Country: China
ProdList: 1391
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9958
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9652
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Email: sales@pharmablock.com
Country: China
ProdList: 7268
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9765
Advantage: 58

CAREBIO PHARMA

Tel: 18501057619 18501057619;
Email: jackyfan@rebornpharma.com
Country: China
ProdList: 265
Advantage: 58

Shanghai Weiyite Biotechnology Co., Ltd

Tel: 15317051735
Email: zhaojing@wytsci.com
Country: China
ProdList: 9980
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

210110-90-0, N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDERelated Search:

Nafamostat mesylate Ketoconazole Zafirlukast Vorinostat Sulfanilamide (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Deoxynojirimycin hydrochloride 2,2'-(Butylimino)diethanol N-METHYL-1-DEOXYNOJIRIMYCIN 1-Deoxynojirimycin (R)-3-Hydroxypiperidine hydrocloride N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN, HYDROCHLORIDE N-BUTYLDEOXYNOJIRIMYCIN N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE trans-3,4-Dihydroxypiperidine 1,5-DIDEOXY-1,5-IMINO-XYLITOL N-Dodecyldeoxynojirimycin

Miglustat, Hydrochloride

(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-,3,4,5-Piperidinetriol Hydrochloride

N-BUTYLDEOXYNOJIRIMYCIN HCL

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE

N-BUTYL-DNJ, HCL

NB-DNJ, HCL

N-(N-BUTYL)DEOXYNOJIRIMYCIN, HYDROCHLORIDE

(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride

Miglustat hydrochloride, N-(n-Butyl)deoxynojirimycin hydrochloride

(2R,3R,4R,5S)-

Miglustat HCl, NB-DNJ HCl, (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

N-(n-Butyl)-1-deoxynojirimycin hydrochloride min. 99%

Miglustat HCl

(2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

NB-DNJ hydrochloride

N-BUTYLDEOXYNOJIRIMYCIN; HYDROCHLORIDE;NB-DNJ HYDROCHLORIDE;OGT918 HYDROCHLORIDE;ZAVESCA HYDROCHLORIDE

OGT918 hydrochloride

Zavesca hydrochloride

N-(n-Butyl)-1-deoxynojirimycin hydrochloride

Miglustat hydrochloride(N-Butyldeoxynojirimycin, Hydrochloride)

Miglustat HCl (OGT-918

N-Butyldeoxynojirimycin,OGT-918,type I gaucher disease,Miglustat,Miglustat hydrochloride,oral,Glucosylceramide Synthase (GCS),OGT918,ceramide glucosyltransferase,NB-DNJ,Inhibitor,inhibit,OGT 918

Miglustat hydrochloride, 10 mM in DMSO

210110-90-0

C10H21NO4HCl

Glycosidase Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

All Inhibitors