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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE

Product Name
N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
CAS No.
210110-90-0
Chemical Name
N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
Synonyms
NB-DNJ, HCL;Miglustat HCl;(2R,3R,4R,5S)-;N-BUTYL-DNJ, HCL;NB-DNJ hydrochloride;OGT918 hydrochloride;Zavesca hydrochloride;Miglustat HCl (OGT-918;Miglustat, Hydrochloride;N-BUTYLDEOXYNOJIRIMYCIN HCL
CBNumber
CB7328886
Molecular Formula
C10H22ClNO4
Formula Weight
255.74
MOL File
210110-90-0.mol
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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Property

Melting point:
169-172°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
form 
White to off-white solid.
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
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Safety

Hazard Codes 
Xi
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21065
Product name
N-Butyldeoxynojirimycin (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
21065
Product name
N-Butyldeoxynojirimycin (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
21065
Product name
N-Butyldeoxynojirimycin (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
21065
Product name
N-Butyldeoxynojirimycin (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$353
Updated
2024/03/01
Tocris
Product number
3117
Product name
Miglustathydrochloride
Packaging
10
Price
$227
Updated
2021/12/16
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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Miglustat HCl (210110-90-0) is an orally active ceramide-specific glycosyltransferase and α-glucosidase I and II inhibitor.1 Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II.2 Pharmacological chaperone for glucocerebrosidase degradation.3 Clinically useful agent for Gaucher disease type 1.4 Stabilizes neurological disorders in Niemann-Pick disease type C.5

Chemical Properties

White Crystals

Uses

An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. N-Butyldeoxynojirimycin has recently been used to retard lipid storage in the central nervous system of an animal m odel of Tay-Sachs disease. 1-Deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.

storage

Desiccate at -20°C

References

1) Platt et al. (1994), N-butyldeoxynojirimycin is a novel inhibitor if glycolipid biosynthesis; J. Biol. Chem., 269 8362 2) Noel et al. (2008), Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis; J. Pharmacol. Exp. Ther., 325 1016 3) Abian et al. (2011), Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase; Mol. Pharm., 8 2390 4) Serratrice et al. (2015), Switching from imiglucerase to miglustat for the treatment of French patients with Gaucher disease type 1: a case series; J. Med. Case Rep., 9 146 5) Karimzadeh (2013), Effects of miglustat on stabilization of neurological disorder in niemann-pick disease type C: Iranian pediatric case series; J. Child Neurol., 28 1599

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Suppliers

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210110-90-0, N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDERelated Search:

Nafamostat mesylate Ketoconazole Zafirlukast Vorinostat Sulfanilamide (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Deoxynojirimycin hydrochloride 2,2'-(Butylimino)diethanol N-METHYL-1-DEOXYNOJIRIMYCIN 1-Deoxynojirimycin (R)-3-Hydroxypiperidine hydrocloride N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN, HYDROCHLORIDE N-BUTYLDEOXYNOJIRIMYCIN N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE trans-3,4-Dihydroxypiperidine 1,5-DIDEOXY-1,5-IMINO-XYLITOL N-Dodecyldeoxynojirimycin

  • Miglustat, Hydrochloride
  • (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-,3,4,5-Piperidinetriol Hydrochloride
  • N-BUTYLDEOXYNOJIRIMYCIN HCL
  • N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
  • N-BUTYL-DNJ, HCL
  • NB-DNJ, HCL
  • N-(N-BUTYL)DEOXYNOJIRIMYCIN, HYDROCHLORIDE
  • (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride
  • Miglustat hydrochloride, N-(n-Butyl)deoxynojirimycin hydrochloride
  • (2R,3R,4R,5S)-
  • Miglustat HCl, NB-DNJ HCl, (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
  • N-(n-Butyl)-1-deoxynojirimycin hydrochloride min. 99%
  • Miglustat HCl
  • (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
  • NB-DNJ hydrochloride
  • N-BUTYLDEOXYNOJIRIMYCIN; HYDROCHLORIDE;NB-DNJ HYDROCHLORIDE;OGT918 HYDROCHLORIDE;ZAVESCA HYDROCHLORIDE
  • OGT918 hydrochloride
  • Zavesca hydrochloride
  • N-(n-Butyl)-1-deoxynojirimycin hydrochloride
  • Miglustat hydrochloride(N-Butyldeoxynojirimycin, Hydrochloride)
  • Miglustat HCl (OGT-918
  • N-Butyldeoxynojirimycin,OGT-918,type I gaucher disease,Miglustat,Miglustat hydrochloride,oral,Glucosylceramide Synthase (GCS),OGT918,ceramide glucosyltransferase,NB-DNJ,Inhibitor,inhibit,OGT 918
  • 210110-90-0
  • C10H21NO4HCl
  • Glycosidase Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • All Inhibitors