N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE

Product Name: N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
CAS No.: 210110-90-0
Chemical Name: N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
Synonyms: NB-DNJ, HCL;Miglustat HCl;(2R,3R,4R,5S)-;N-BUTYL-DNJ, HCL;NB-DNJ hydrochloride;OGT918 hydrochloride;Zavesca hydrochloride;Miglustat HCl (OGT-918;Miglustat, Hydrochloride;N-BUTYLDEOXYNOJIRIMYCIN HCL
CBNumber: CB7328886
Molecular Formula: C10H22ClNO4
Formula Weight: 255.74
MOL File: 210110-90-0.mol

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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Property

Melting point:: 169-172°C
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
form: White to off-white solid.
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

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Safety

Hazard Codes: Xi
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 21065
Product name: N-Butyldeoxynojirimycin (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $353
Updated: 2024/03/01

Tocris

Product number: 3117
Product name: Miglustathydrochloride
Packaging: 10
Price: $227
Updated: 2021/12/16

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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Miglustat HCl (210110-90-0) is an orally active ceramide-specific glycosyltransferase and α-glucosidase I and II inhibitor.1 Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II.2 Pharmacological chaperone for glucocerebrosidase degradation.3 Clinically useful agent for Gaucher disease type 1.4 Stabilizes neurological disorders in Niemann-Pick disease type C.5

Chemical Properties

White Crystals

Uses

An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. N-Butyldeoxynojirimycin has recently been used to retard lipid storage in the central nervous system of an animal m odel of Tay-Sachs disease. 1-Deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.

storage

Desiccate at -20°C

References

1) Platt et al. (1994), N-butyldeoxynojirimycin is a novel inhibitor if glycolipid biosynthesis; J. Biol. Chem., 269 8362 2) Noel et al. (2008), Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis; J. Pharmacol. Exp. Ther., 325 1016 3) Abian et al. (2011), Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase; Mol. Pharm., 8 2390 4) Serratrice et al. (2015), Switching from imiglucerase to miglustat for the treatment of French patients with Gaucher disease type 1: a case series; J. Med. Case Rep., 9 146 5) Karimzadeh (2013), Effects of miglustat on stabilization of neurological disorder in niemann-pick disease type C: Iranian pediatric case series; J. Child Neurol., 28 1599

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Suppliers

Canada 1 China 60 Germany 1 United Kingdom 5 United States 14 Global 81

J & K SCIENTIFIC LTD.

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210110-90-0, N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDERelated Search:

Nafamostat mesylate Ketoconazole Zafirlukast Vorinostat Sulfanilamide (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Deoxynojirimycin hydrochloride 2,2'-(Butylimino)diethanol N-METHYL-1-DEOXYNOJIRIMYCIN 1-Deoxynojirimycin (R)-3-Hydroxypiperidine hydrocloride N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN, HYDROCHLORIDE N-BUTYLDEOXYNOJIRIMYCIN N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE trans-3,4-Dihydroxypiperidine 1,5-DIDEOXY-1,5-IMINO-XYLITOL N-Dodecyldeoxynojirimycin

Miglustat, Hydrochloride

(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-,3,4,5-Piperidinetriol Hydrochloride

N-BUTYLDEOXYNOJIRIMYCIN HCL

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE

N-BUTYL-DNJ, HCL

NB-DNJ, HCL

N-(N-BUTYL)DEOXYNOJIRIMYCIN, HYDROCHLORIDE

(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride

Miglustat hydrochloride, N-(n-Butyl)deoxynojirimycin hydrochloride

(2R,3R,4R,5S)-

Miglustat HCl, NB-DNJ HCl, (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

N-(n-Butyl)-1-deoxynojirimycin hydrochloride min. 99%

Miglustat HCl

(2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

NB-DNJ hydrochloride

N-BUTYLDEOXYNOJIRIMYCIN; HYDROCHLORIDE;NB-DNJ HYDROCHLORIDE;OGT918 HYDROCHLORIDE;ZAVESCA HYDROCHLORIDE

OGT918 hydrochloride

Zavesca hydrochloride

N-(n-Butyl)-1-deoxynojirimycin hydrochloride

Miglustat hydrochloride(N-Butyldeoxynojirimycin, Hydrochloride)

Miglustat HCl (OGT-918

N-Butyldeoxynojirimycin,OGT-918,type I gaucher disease,Miglustat,Miglustat hydrochloride,oral,Glucosylceramide Synthase (GCS),OGT918,ceramide glucosyltransferase,NB-DNJ,Inhibitor,inhibit,OGT 918

210110-90-0

C10H21NO4HCl

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