9H-PYRIDO[3,4-B]INDOLE
- Product Name
- 9H-PYRIDO[3,4-B]INDOLE
- CAS No.
- 244-63-3
- Chemical Name
- 9H-PYRIDO[3,4-B]INDOLE
- Synonyms
- NORHARMAN;NORHARMANE;β-carboline;BETA-CARBOLINE;B-CARBOLINE;Pyridoindole;NSC 8441;NSC 84417;9H-BETA-CA;CARBAZOLINE
- CBNumber
- CB5431618
- Molecular Formula
- C11H8N2
- Formula Weight
- 168.19
- MOL File
- 244-63-3.mol
9H-PYRIDO[3,4-B]INDOLE Property
- Melting point:
- 199-201 °C
- Boiling point:
- 287.13°C (rough estimate)
- Density
- 1.1722 (rough estimate)
- refractive index
- 1.5200 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- 15.44±0.30(Predicted)
- form
- crystalline
- color
- light yellow
- Water Solubility
- 2693g/L(17 ºC)
- InChIKey
- AIFRHYZBTHREPW-UHFFFAOYSA-N
- LogP
- 3.170
- CAS DataBase Reference
- 244-63-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 36/37/39-26-22
- RIDADR
- 3261
- WGK Germany
- 3
- RTECS
- UU9350000
- HS Code
- 29339900
- Toxicity
- dnd-hmn:hla 50 mmol/L MUREAV 89,95,81
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N6252
- Product name
- Norharmane
- Purity
- crystalline
- Packaging
- 100mg
- Price
- $47.1
- Updated
- 2024/03/01
- Product number
- N6252
- Product name
- Norharmane
- Purity
- crystalline
- Packaging
- 1g
- Price
- $240
- Updated
- 2024/03/01
- Product number
- P1121
- Product name
- 9H-Pyrido[3,4-b]indole
- Purity
- >98.0%(GC)(T)
- Packaging
- 100mg
- Price
- $35
- Updated
- 2024/03/01
- Product number
- 20043
- Product name
- Norharmane
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 20043
- Product name
- Norharmane
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $68
- Updated
- 2024/03/01
9H-PYRIDO[3,4-B]INDOLE Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
The compund has cytotoxic effects.
Uses
Used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.
Definition
ChEBI: The parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring.
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 2962, 1950 DOI: 10.1021/ja01163a041
Tetrahedron, 49, p. 49, 1993 DOI: 10.1016/S0040-4020(01)80505-6
Hazard
Toxic; nervous system effects.
Biological Activity
norharmane acts as a co-mutagen. norharmane is a natural β-carboline first isolated from plants of the zygophyllaceae family. it is a heterocyclic amine (hca) that may also be found in fried meats, tobacco smoke, and coffee. harman and norharmane are aminocarbolines known as “co-mutagens” because they do not show mutagenicity to salmonella serovar typhimurium [1][2][3].norharmane acts as a co-mutagen. norharmane is widely distributed in our environment. it was not mutagenic to salmonella typhimurium ta98 and ta100 either with or without s9 mix, but became mutagenic to s.typhimurium ta98 with s9 mix when non-mutagenic aromatic amines like aniline or o- or m-toluidine are added. also, norharmane and aromatic amines induced the formation of dna adduct in s.typhimurium ta98 [3].harman and norharmane with concentrations of 0.275 um and 0.9 um respectively might inhibited mao-a and mao-b. in adult male rats, a novel cocktail of cigarette smoke constituents, containing five minor alkaloids (nornicotine, cotinine, myosmine, anatabine, and anabasine), two β-carbolines (harman and norharmane), and acetaldehyde, did not significantly enhance nicotine self-administration [2].
Biochem/physiol Actions
Inhibitor of indoleamine 2,3-dioxygenase (IDO).
Safety Profile
Poison by intravenous route.Experimental reproductive effects. Human mutation datareported. When heated to decomposition it emits toxicfumes of NOx.
References
[1]. jamali ma, zhang y, teng h, et al. inhibitory effect of rosa rugosa tea extract on the formation of heterocyclic amines in meat patties at different temperatures. molecules. 2016 jan 30;21(2):173.
[2]. smith tt, schaff mb, rupprecht le, et al. effects of mao inhibition and a combination of minor alkaloids, β-carbolines, and acetaldehyde on nicotine self-administration in adult male rats. drug alcohol depend. 2015 oct 1;155:243-52.
[3]. mori m1, totsuka y, fukutome k, et al. formation of dna adducts by the co-mutagen norharman with aromatic amines. carcinogenesis. 1996 jul;17(7):1499-503.
9H-PYRIDO[3,4-B]INDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 9H-PYRIDO[3,4-B]INDOLE manufacturers
- Product
- 9H-PYRIDO[3,4-B]INDOLE 244-63-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-14
- Product
- 9H-PYRIDO[3,4-B]INDOLE 244-63-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-06
- Product
- 9H-PYRIDO[3,4-B]INDOLE 244-63-3
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 1000KG
- Release date
- 2018-08-10