ChemicalBook > CAS DataBase List > 1,3-BENZOTHIAZOL-5-AMINE

1,3-BENZOTHIAZOL-5-AMINE

Product Name: 1,3-BENZOTHIAZOL-5-AMINE
CAS No.: 1123-93-9
Chemical Name: 1,3-BENZOTHIAZOL-5-AMINE
Synonyms: benzo[d]thiazol-5-aMine;5-AMinobenzothiazole;BENZOTHIAZOL-5-YLAMINE;5-Amino-1,3-benzothiazole;NSC 170655;5-BENZOTHIAZOLAMINE;CHEMBRDG-BB 4003348;benzothiazol-5-amine;3-Benzothiazol-5-amine;1,3-BENZOTHIAZOL-5-AMINE
CBNumber: CB5432347
Molecular Formula: C7H6N2S
Formula Weight: 150.2
MOL File: 1123-93-9.mol

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1,3-BENZOTHIAZOL-5-AMINE Property

Melting point:: 55 °C
Boiling point:: 323.1±15.0 °C(Predicted)
Density: 1.383
storage temp.: 2-8°C(protect from light)
form: powder
pka: 2.44±0.10(Predicted)
color: Yellow
Water Solubility: Sparingly soluble in water.(0.26 g/L) (25°C),
InChI: InChI=1S/C7H6N2S/c8-5-1-2-7-6(3-5)9-4-10-7/h1-4H,8H2
InChIKey: UJZYHMZRXGNDFB-UHFFFAOYSA-N
SMILES: S1C2=CC=C(N)C=C2N=C1

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38-36-22
Safety Statements: 22-26-36/37/39
RIDADR: 2811
Hazard Note: Harmful
TSCA: Yes
HazardClass: IRRITANT
HS Code: 2934208090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2912
Product name: Benzo[d]thiazol-5-amine
Packaging: 1G
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: A2912
Product name: Benzo[d]thiazol-5-amine
Packaging: 5G
Price: $153
Updated: 2025/07/31

TRC

Product number: B130063
Product name: 1,3-Benzothiazol-5-amine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H70-1-Y6
Product name: 5-Amino-1,3-benzothiazole
Purity: 95%
Packaging: 1g
Price: $21
Updated: 2021/12/16

AK Scientific

Product number: Z7380
Product name: 1,3-Benzothiazol-5-amine
Packaging: 1g
Price: $25
Updated: 2021/12/16

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1,3-BENZOTHIAZOL-5-AMINE Chemical Properties,Usage,Production

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Synthesis

2942-07-6

1123-93-9

General procedure for the synthesis of 1,3-benzothiazol-5-amine from 5-nitrobenzothiazole: A mixture of 5-nitro-1,3-benzothiazole (5.1 g, 11 mmol) and stannous(II) chloride dihydrate (8.6 g, 38 mmol) in 2-propanol (30 mL) was heated to reflux and the reaction was sustained for 24 hr. Upon completion of the reaction, the cooled reaction mixture was poured into an ice/water mixture (85 mL) and the pH was adjusted with sodium hydroxide solution to 7. Subsequently, the mixture was extracted with ethyl acetate (3 x 50 mL), and the organic layers were combined and dried over anhydrous sodium sulfate. The dried organic phase was filtered and concentrated and the residue was purified by silica gel column chromatography (eluent ratio 1:1 hexane:ethyl acetate) to afford the target product 1,3-benzothiazol-5-amine (820 mg, 52% yield). The product was characterized by LHNMR (CDCl3): δ 6.85 (1H, dd, J=2.3,8.6 Hz), 7.40 (1H, d, J=2.1 Hz), 7.66 (1H, d, J=8.4 Hz), 8.90 (1H, s).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 3, p. 957 - 971
[2] Catalysis Letters, 2014, vol. 144, # 7, p. 1258 - 1267
[3] Patent: WO2005/28445, 2005, A2. Location in patent: Page/Page column 28
[4] Yakugaku Zasshi, 1942, vol. 62, p. 47,51; dtsch. Ref. S. 19, 22
[5] Chem.Abstr., 1951, p. 609

1,3-BENZOTHIAZOL-5-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,3-BENZOTHIAZOL-5-AMINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1,3-BENZOTHIAZOL-5-AMINE 1123-93-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-18

Shaanxi Dideu Medichem Co. Ltd

Product: 1,3-BENZOTHIAZOL-5-AMINE 1123-93-9
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-07-14

Career Henan Chemical Co

Product: 1,3-BENZOTHIAZOL-5-AMINE 1123-93-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2019-08-05

1123-93-9, 1,3-BENZOTHIAZOL-5-AMINERelated Search:

2-METHYL-5-NITROBENZOTHIAZOLE 5-NITRO-BENZOTHIAZOL-2-YLAMINE 2-Chloro-5-benzothiazolamine 1,3-BENZOTHIAZOL-5-AMINE 5-AMINO-2-METHYLBENZOTHIAZOLE 5-Nitrobenzothiazole-2-thiol 5-NITROBENZOTHIAZOLE 4-BROMO-BENZOTHIAZOL-5-YLAMINE Benzothiazole, 2-chloro-5-nitro- (7CI,8CI,9CI) N-METHYL-1,3-BENZOTHIAZOL-2-AMINE HYDROBROMIDE 4,6-Dichloro-1,3-benzothiazol-2-amine 4-(trifluoromethyl)benzothiazol-2-amine benzothiazol-6-amine 2-(METHYLTHIO)-1,3-BENZOTHIAZOL-6-AMINE 1,3-BENZOTHIAZOL-2-AMINE 2-AMINO-4,6-DIFLUOROBENZOTHIAZOLE Pramipexole 2,1,3-BENZOTHIADIAZOL-5-AMINE

CHEMBRDG-BB 4003348

BENZOTHIAZOL-5-YLAMINE

BENZOTHIAZOL-5-YLAMINE HYDROCHLORIDE

1,3-BENZOTHIAZOL-5-AMINE

1,3-BENZOTHIAZOL-5-YLAMINE

5-Amino-1,3-benzothiazole90%

1,3-benzothiazol-5-amine(SALTDATA: FREE)

benzo[d]thiazol-5-aMine

5-AMinobenzothiazole

5-BENZOTHIAZOLAMINE

5-BENZOTHIAZOLAMINE HYDROCHLORIDE

benzothiazol-5-amine

5-Amino-1,3-benzothiazole

5-Benzothiazolamine (9CI)

5-Amino-1,3-benzothiazole 90%

1,3-Benzothiazole-5-aMine

NSC 170655

1,3-Benzothiazol-5-amine, 5-Aminobenzo[d]thiazole

3-Benzothiazol-5-amine

5-Aminobenzothiazole,96%

1123-93-9

C7H6N2SHCl

BENZOTHIAZOLE