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Diatrizoate sodium

Description References
Product Name
Diatrizoate sodium
CAS No.
737-31-5
Chemical Name
Diatrizoate sodium
Synonyms
SodiuM diatrizoate hydrate;hypaque;histopaque;SODIUM DIATRIZOATE;Sodium amidotrizoate;win8308-3;Conray 35;hypaque50;triombrine;HYPAQUE SODIUM
CBNumber
CB5435661
Molecular Formula
C11H8I3N2NaO4
Formula Weight
635.9
MOL File
737-31-5.mol
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Diatrizoate sodium Property

Melting point:
261-262° (dec)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: 0.35 g/mL, slightly turbid, colorless
form 
White Powder
color 
White to off-white
BRN 
4082984
InChI
InChI=1S/C11H9I3N2O4.Na/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;/h1-2H3,(H,15,17)(H,16,18)(H,19,20);/q;+1/p-1
InChIKey
ZEYOIOAKZLALAP-UHFFFAOYSA-M
SMILES
C1(NC(=O)C)C(I)=C(C(I)=C(C([O-])=O)C=1I)NC(=O)C.[Na+]
CAS DataBase Reference
737-31-5(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, monosodium salt (737-31-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
42/43
Safety Statements 
36
WGK Germany 
3
RTECS 
DG6125000
8-10
HS Code 
29242100
Hazardous Substances Data
737-31-5(Hazardous Substances Data)
Toxicity
LD50 i.v. in rats: 14.7 g/kg (Langecker)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S4506
Product name
Sodium diatrizoate hydrate
Purity
≥98.0%
Packaging
10g
Price
$39.1
Updated
2024/03/01
Sigma-Aldrich
Product number
S4506
Product name
Sodium diatrizoate hydrate
Purity
≥98.0%
Packaging
50g
Price
$147
Updated
2024/03/01
Sigma-Aldrich
Product number
S4506
Product name
Sodium diatrizoate hydrate
Purity
≥98.0%
Packaging
100g
Price
$210
Updated
2024/03/01
Sigma-Aldrich
Product number
S4506
Product name
Sodium diatrizoate hydrate
Purity
≥98.0%
Packaging
250g
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
S4506
Product name
Sodium diatrizoate hydrate
Purity
≥98.0%
Packaging
500g
Price
$698
Updated
2024/03/01
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Diatrizoate sodium Chemical Properties,Usage,Production

Description

Diatrizoate sodium is a contrast agent used during the X-rays test. It can be used as a diagnostic aid agent during angiography, urography and radiography. It can be applied during visualizing veins, the urinary system, gastrointestinal tract, spleen and joints as well as during the computer tomography (CT scan). It is used in cases where barium is not suitable for application such as patient being allergic to barium.

References

https://en.wikipedia.org/wiki/Diatrizoate
https://pubchem.ncbi.nlm.nih.gov/compound/Diatrizoate_sodium

Chemical Properties

Diatrizoate sodium is a white or almost white powder that has no odor and a slightly salty taste. It dissolves easily in water but only slightly dissolves in ethanol, and it does not dissolve in ether. A 50% aqueous solution has a pH between 6.5 and 8.0. The substance has an iodine content of approximately 59.9%.

Originator

Hypaque Sodium,Winthrop,US,1955

Uses

Diatrizoate Sodium is an iodinated radiopaque X-ray contrast medium used in radiology for diagnostic purposes. It is also used as a density gradient reagent to separate blood cells.

Definition

ChEBI: Sodium amidotrizoate is the sodium salt of a benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, often as a mixture with the meglumine salt, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography. It has a role as a radioopaque medium. It is an organoiodine compound and an organic sodium salt. It contains an amidotrizoic acid anion.

Manufacturing Process

3,5-Dinitrobenzoic acid (15.9 g) was dissolved in an equivalent amount of sodium hydroxide solution, and the solution was diluted to 310 ml with water. The solution was refluxed with Raney nickel for fifteen minutes, filtered, and the filtrate was hydrogenated at elevated pressure using platinum oxide catalyst. After the amount of hydrogen calculated to reduce both nitro groups had been absorbed, the mixture was filtered, and the filtrate was acidified with an equal volume of concentrated hydrochloric acid. Iodine monochloride (17 ml) in 100 ml of 6N HCl was then added with stirring. The reaction mixture was allowed to stand for two and one-half hours at room temperature, then diluted with an equal amount of water with vigorous stirring, and the solid material was collected by filtration and recrystallized
from dilute methanol, giving 18.5 g of 3,5-diamino-2,4,6-triiodobenzoic acid, MP about 135°C with decomposition. The 18.5 g of 3,5-diamino-2,4,6- triiodobenzoic acid was suspended in 150 ml of acetic anhydride containing 5 drops of 70% perchloric acid, and the mixture was heated on a steam bath for three and one-half hours. The reaction mixture was poured into 300 ml of ice water, and then heated on a steam bath until crystallization took place. The solid material was collected by filtration, dissolvedin dilute sodium hydroxide solution, filtered, and hydrochloric acid was added to the filtrate to reprecipitate the acid product. The latter was again dissolved in sodium hydroxide and reprecipitated with acid, giving 9 g of 3,5-diacetamido-2,4,6- triiodobenzoic acid, MP above 250°C.
The acid may be used as the sodium salt or as the meglumate.

brand name

Md (Mallinckrodt); Urovist Sodium (Berlex).

Therapeutic Function

Diagnostic aid (radiopaque medium)

Mode of action

The mechanism of action of Diatrizoate sodium is that it can block the X-rays so that the body structure containing iodine to be delineated in contrast to those structures that free of iodine, further allowing the visualization of those related areas.

Diatrizoate sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Diatrizoate sodium Suppliers

Wuhan Silworld Chemical Co.,Ltd
Tel
027-85613400 15827173649
Fax
027-85613419
Email
info@silworldchemical.com
Country
China
ProdList
325
Advantage
58
Jiangsu Lingyi Chemical Technology Co., Ltd.
Tel
0523-87653988 15961022226
Email
214703666@qq.com
Country
China
ProdList
117
Advantage
58
Hubei kangen Pharmaceutical Chemical Co., Ltd
Tel
15337215803 15337215803
Fax
027-89771658
Email
3357312443@qq.com
Country
China
ProdList
232
Advantage
56
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
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View Lastest Price from Diatrizoate sodium manufacturers

Hubei Lidu New Material Technology Co., Ltd
Product
DIATRIZOATE SODIUM 737-31-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20tons
Release date
2024-09-24
Asia Chem I and E (Jiangsu) Co Ltd
Product
Sodium diatrizoate hydrate 737-31-5
Price
US $251.16/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.0%HPLC
Supply Ability
1ton/month
Release date
2021-09-22
Hebei Chuanghai Biotechnology Co,.LTD
Product
Sodium Diatrizoate 737-31-5
Price
US $10.70/kg
Min. Order
10kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-23

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