Sodium D-pantothenate
Description References- Product Name
- Sodium D-pantothenate
- CAS No.
- 867-81-2
- Chemical Name
- Sodium D-pantothenate
- Synonyms
- SODIUM PANTOTHENATE;D-Pantothenic;D-Pantothenate Sodium;D-PANTOTHENIC ACID SODIUM SALT;heta)-;Sodium D;SodiuM D-Pan;vitamin B5 sodium;PANTOTHENATESODIUM;SODIUM PANTHOTENATE
- CBNumber
- CB6256810
- Molecular Formula
- C9H16NNaO5
- Formula Weight
- 241.22
- MOL File
- 867-81-2.mol
Sodium D-pantothenate Property
- Melting point:
- 171-178 °C(lit.)
- alpha
- D25 +27.1° (c = 2)
- refractive index
- 27 ° (C=5, H2O)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Water (Slightly)
- form
- Solid
- color
- White to Off-White
- optical activity
- 24.2°(C=0.01g/mI, H2O, 20°C, 589nm)
- Stability:
- Hygroscopic
- InChI
- InChI=1/C9H17NO5.Na/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;+1/p-1/t7-;/s3
- InChIKey
- GQTHJBOWLPZUOI-WMASNCOMNA-M
- SMILES
- [C@H](O)(C(=O)NCCC([O-])=O)C(C)(C)CO.[Na+] |&1:0,r|
- LogP
- -0.849 (est)
- CAS DataBase Reference
- 867-81-2(CAS DataBase Reference)
- EPA Substance Registry System
- .beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, monosodium salt (867-81-2)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-48-41-37/38-20/21/22
- Safety Statements
- 26-36-45-36/37/39-22-24/25
- HS Code
- 29241990
- Hazardous Substances Data
- 867-81-2(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- P0013
- Product name
- Sodium D-Pantothenate
- Purity
- >97.0%(N)
- Packaging
- 25g
- Price
- $67
- Updated
- 2025/07/31
- Product number
- P0013
- Product name
- Sodium D-Pantothenate
- Purity
- >97.0%(N)
- Packaging
- 250g
- Price
- $624
- Updated
- 2025/07/31
- Product number
- 17288
- Product name
- D-Pantothenic Acid (sodium salt)
- Purity
- ≥98%
- Packaging
- 25g
- Price
- $71
- Updated
- 2024/03/01
- Product number
- 17288
- Product name
- D-Pantothenic Acid (sodium salt)
- Purity
- ≥98%
- Packaging
- 50g
- Price
- $133
- Updated
- 2024/03/01
- Product number
- 17288
- Product name
- D-Pantothenic Acid (sodium salt)
- Purity
- ≥98%
- Packaging
- 100g
- Price
- $254
- Updated
- 2024/03/01
Sodium D-pantothenate Chemical Properties,Usage,Production
Description
Sodium D-pantothenate is the sodium salt of the biological active enantiomer of pantothenic acid (vitamin B5). As D-pantothenic acid is a precursor in the biosynthesis of coenzyme A, sodium D- pantothenate is used in the synthesis of coenzyme A. It is also used in foods as a dietary supplement.
References
[1] George A. Burdock, Encyclopedia of Food and Color Additives, volume 3, 1996
Chemical Properties
White crystal or powder
Uses
D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].
Synthesis
16690-93-0
599-04-2
867-81-2
The general procedure for the synthesis of sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propionate from sodium 3-aminopropionate and dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone was as follows: 55.5 g of sodium 3-aminopropionate and 65 g of dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone were dissolved in 350 ml of anhydrous ethanol and heated to reflux for 3 hours. After completion of the reaction, the reaction mixture was filtered while hot and the reaction vessel was washed with 50 ml of ethanol. The washed solution was combined with the filtrate and the combined filtrate was allowed to stand at 0 °C for 5 days. Subsequently, it was filtered and the resulting solid was washed with a small amount of ethanol. Finally, the solid was dried to constant weight under reduced pressure at room temperature to obtain 76.3 g of white crystalline powder, namely sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propionate (sodium D-pantothenate), whose crystal structure is as described in GB565976.
in vivo
Pantothenic acid (PTA; 3x10, 3x100, and 3x300 mg/kg) decreases Valproic acid (VPA; 300, 400, and 500 mg/kg, s.c.)-induced neural tube defects in mice[2].
| Animal Model: | Female ICR mice weighing 29-35 g[2] |
| Dosage: | 3x10, 3x100, and 3x300 mg/kg (10 mL/kg, volume administered) |
| Administration: | Injected intraperitoneally (i.p.) on day 8.5 of gestation |
| Result: | Significantly reduced VPA (300, 400, and 500 mg/kg, s.c.)-induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced. |
IC 50
Human Endogenous Metabolite
Purification Methods
Crystallise the salt from absolute EtOH. It is very hygroscopic (keep in sealed ampoules). The free acid is a viscous hygroscopic oil with [] 25D +37.5o (c 5, H2O), easily destroyed by acids and bases. [Beilstein 4 IV 2569.]
References
[1] Shuai Chen, et al. Metabolomic analysis of the toxic effect of chronic exposure of cadmium on rat urine. Environ Sci Pollut Res Int. 2018 Feb;25(4):3765-3774. DOI:10.1007/s11356-017-0774-8
[2] M Sato, et al. Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I). Teratology. 1995 Sep;52(3):143-8. DOI:10.1002/tera.1420520306
Sodium D-pantothenate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Sodium D-pantothenate manufacturers
- Product
- Sodium D-pantothenate 867-81-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2025-10-29
- Product
- Sodium D-pantothenate 867-81-2
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kg
- Release date
- 2021-08-19
- Product
- Sodium D-pantothenate 867-81-2
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-18