ChemicalBook > CAS DataBase List > Sodium D-pantothenate

Sodium D-pantothenate

Description References

Product Name: Sodium D-pantothenate
CAS No.: 867-81-2
Chemical Name: Sodium D-pantothenate
Synonyms: SODIUM PANTOTHENATE;D-Pantothenic;D-Pantothenate Sodium;D-PANTOTHENIC ACID SODIUM SALT;heta)-;Sodium D;SodiuM D-Pan;vitamin B5 sodium;PANTOTHENATESODIUM;SODIUM PANTHOTENATE
CBNumber: CB6256810
Molecular Formula: C9H16NNaO5
Formula Weight: 241.22
MOL File: 867-81-2.mol

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Sodium D-pantothenate Property

Melting point:: 171-178 °C(lit.)
alpha: D25 +27.1° (c = 2)
refractive index: 27 ° (C=5, H2O)
storage temp.: Inert atmosphere,2-8°C
solubility: Water (Slightly)
form: Solid
color: White to Off-White
optical activity: 24.2°(C=0.01g/mI, H2O, 20°C, 589nm)
Stability:: Hygroscopic
InChI: InChI=1/C9H17NO5.Na/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;+1/p-1/t7-;/s3
InChIKey: GQTHJBOWLPZUOI-WMASNCOMNA-M
SMILES: [C@H](O)(C(=O)NCCC([O-])=O)C(C)(C)CO.[Na+] |&1:0,r|
LogP: -0.849 (est)
CAS DataBase Reference: 867-81-2(CAS DataBase Reference)
EPA Substance Registry System: .beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, monosodium salt (867-81-2)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-48-41-37/38-20/21/22
Safety Statements: 26-36-45-36/37/39-22-24/25
HS Code: 29241990
Hazardous Substances Data: 867-81-2(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P0013
Product name: Sodium D-Pantothenate
Purity: >97.0%(N)
Packaging: 25g
Price: $67
Updated: 2025/07/31

TCI Chemical

Product number: P0013
Product name: Sodium D-Pantothenate
Purity: >97.0%(N)
Packaging: 250g
Price: $624
Updated: 2025/07/31

Cayman Chemical

Product number: 17288
Product name: D-Pantothenic Acid (sodium salt)
Purity: ≥98%
Packaging: 25g
Price: $71
Updated: 2024/03/01

Cayman Chemical

Product number: 17288
Product name: D-Pantothenic Acid (sodium salt)
Purity: ≥98%
Packaging: 50g
Price: $133
Updated: 2024/03/01

Cayman Chemical

Product number: 17288
Product name: D-Pantothenic Acid (sodium salt)
Purity: ≥98%
Packaging: 100g
Price: $254
Updated: 2024/03/01

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Sodium D-pantothenate Chemical Properties,Usage,Production

Description

Sodium D-pantothenate is the sodium salt of the biological active enantiomer of pantothenic acid (vitamin B5). As D-pantothenic acid is a precursor in the biosynthesis of coenzyme A, sodium D- pantothenate is used in the synthesis of coenzyme A. It is also used in foods as a dietary supplement.

References

[1] George A. Burdock, Encyclopedia of Food and Color Additives, volume 3, 1996

Chemical Properties

White crystal or powder

Uses

D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].

Synthesis

16690-93-0

599-04-2

867-81-2

The general procedure for the synthesis of sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propionate from sodium 3-aminopropionate and dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone was as follows: 55.5 g of sodium 3-aminopropionate and 65 g of dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone were dissolved in 350 ml of anhydrous ethanol and heated to reflux for 3 hours. After completion of the reaction, the reaction mixture was filtered while hot and the reaction vessel was washed with 50 ml of ethanol. The washed solution was combined with the filtrate and the combined filtrate was allowed to stand at 0 °C for 5 days. Subsequently, it was filtered and the resulting solid was washed with a small amount of ethanol. Finally, the solid was dried to constant weight under reduced pressure at room temperature to obtain 76.3 g of white crystalline powder, namely sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propionate (sodium D-pantothenate), whose crystal structure is as described in GB565976.

in vivo

Pantothenic acid (PTA; 3x10, 3x100, and 3x300 mg/kg) decreases Valproic acid (VPA; 300, 400, and 500 mg/kg, s.c.)-induced neural tube defects in mice^[2].

Animal Model:	Female ICR mice weighing 29-35 g^[2]
Dosage:	3x10, 3x100, and 3x300 mg/kg (10 mL/kg, volume administered)
Administration:	Injected intraperitoneally (i.p.) on day 8.5 of gestation
Result:	Significantly reduced VPA (300, 400, and 500 mg/kg, s.c.)-induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced.

IC 50

Human Endogenous Metabolite

Purification Methods

Crystallise the salt from absolute EtOH. It is very hygroscopic (keep in sealed ampoules). The free acid is a viscous hygroscopic oil with [] 25D +37.5o (c 5, H2O), easily destroyed by acids and bases. [Beilstein 4 IV 2569.]

References

[1] Shuai Chen, et al. Metabolomic analysis of the toxic effect of chronic exposure of cadmium on rat urine. Environ Sci Pollut Res Int. 2018 Feb;25(4):3765-3774. DOI:10.1007/s11356-017-0774-8
[2] M Sato, et al. Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I). Teratology. 1995 Sep;52(3):143-8. DOI:10.1002/tera.1420520306

Sodium D-pantothenate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Sodium D-pantothenate manufacturers

Watson Biotechnology Co.,Ltd

Product: Sodium D-pantothenate 867-81-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2025-10-29

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Sodium D-pantothenate 867-81-2
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kg
Release date: 2021-08-19

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Sodium D-pantothenate 867-81-2
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-18

867-81-2, Sodium D-pantothenate Related Search:

Sodium bicarbonate Calcium D-Pantothenate Butylated Hydroxytoluene Trisodium citrate dihydrate Dimethyl sebacate ETHANE Dimethyl fumarate Dimethyl sulfoxide D-PANTOTHENIC ACID Sodium chlorite Dimethyl ether EC 2.6.1.2 Sodium gluconate Sodium carbonate β-Alanine Butylated hydroxyanisole Dimethyl phthalate Sodium formate

(r)-n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine monosodium salt

SODIUM D-PANTOTHENATE

SODIUM PANTHOTENATE

SODIUM PANTOTHENATE

beta-alanine,n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,monosodiumsalt,(t

heta)-

monosodiumsalt,d-pantothenicaci

N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,monosodiumsalt,(R)-.beta.-Alanine

VitaminB5, (R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine calcium salt

beta-Alanine, n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-monosodium salt, (R)-

Pantothenic acid, monosodium salt, d-

(-)-3-[[(S)-2,4-Dihydroxy-3,3-dimethylbutyryl]amino]propionic acid sodium salt

(-)-N-[(S)-2,4-Dihydroxy-3,3-dimethylbutyryl]-β-alanine sodium salt

Sodium D-pantothenate ,98%

Sodium D-pantothenat

SodiuM D-Pan

(+)-Pantothenic acid sodium salt, (R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine sodium salt

SodiuM (R)-3-(2,4-dihydroxy-3,3-diMethylbutanaMido)propanoate

b-Alanine,N-[(2R)-2,4-dihydroxy-3,3-diMethyl-1-oxobutyl]-, sodiuM salt (1:1)

(R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine calcium salt

(R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine sodium salt

D-Pantothenic

D-Pantothenate Sodium

b-Alanine,N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, sodium salt

Sodium D-Pantothenate CAS: 867-81-2

sodium 3-[(2,4-dihydroxy-4-methyl-1-oxopentyl)amino]propanoate

vitamin B5 sodium

Methyldopa impurity 4

n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,monosodiumsalt,(r)-beta-alanin

n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,monosodiumsalt,(theta)-beta-alanin

pantothenicacid,sodiumsalt

sodiumpantothenicacid

D-PANTOTHENIC ACID, NA SALT

D-PANTOTHENIC ACID SODIUM

D(+)-PANTOTHENIC ACID SODIUM SALT

D-PANTOTHENIC ACID SODIUM SALT

Pantothenic acid sodium

D-PANTOTHENIC ACID SODIUM SALT 97+%

SdoiumPantothenate,>97.5%

PantothenicAcid,SodiumSalt>97.5%

Sodium Dextropantothenate

.beta.-Alanine, N-(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl-, monosodium salt

PANTOTHENATESODIUM

Sodium D

SodiumD-Pantothenate&gt

(R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine monosodium sal

Sodium D-pantothenate USP/EP/BP

D-Pantothenate Sodiumr

Sodium D-Pantothenate, ≥ 97.0%

D-Pantothenate Sodium|||D-Pantothenic acid sodium salt|||Sodium pantothenate|||vitamin B5 sodium

C15845100 D-PantotheniCacid sodium

Brimonidine Impurity 36

D-Pantothenic acid sodium, 10 mM in DMSO

Sodium-O-pantothenate

Sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutamido)propanoate

867-81-2

861-81-2

C9H16NO5Na