(S)-3-N-Boc-aminopiperidine
- Product Name
- (S)-3-N-Boc-aminopiperidine
- CAS No.
- 216854-23-8
- Chemical Name
- (S)-3-N-Boc-aminopiperidine
- Synonyms
- tert-butyl (R)-piperidin-3-ylcarbamate;tert-butyl (S)-piperidin-3-ylcarbamate;(S)-3-(TERT-BUTOXYCARBONYLAMINO)PIPERIDINE;ZZ-7;Alogliptin Impurity 53;S-3-(Boc-Ao)piperidine;Linagliptin Impurity 108;(R)-Boc-3-aminopiperidine;(S)-3-BOC-AMINOPIPERIDINE;(S)-tert-Butyl-(piperidin-
- CBNumber
- CB5438435
- Molecular Formula
- C10H20N2O2
- Formula Weight
- 200.28
- MOL File
- 216854-23-8.mol
(S)-3-N-Boc-aminopiperidine Property
- Melting point:
- 122-127°C
- Boiling point:
- 304.8±31.0 °C(Predicted)
- alpha
- -3 º (c=1, DMF)
- Density
- 1.02±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Freely soluble in ethanol.
- pka
- 12.37±0.20(Predicted)
- form
- Crystalline Powder
- color
- White to off-white
- optical activity
- [α]/D -3.0±0.5°, c = 1 in DMF
- InChIKey
- WUOQXNWMYLFAHT-QMMMGPOBSA-N
- CAS DataBase Reference
- 216854-23-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 37/38-41-36/37/38
- Safety Statements
- 26-39-37/39
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 08601
- Product name
- (S)-3-(Boc-amino)piperidine
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $108
- Updated
- 2022/05/15
- Product number
- B3660
- Product name
- (S)-3-(tert-Butoxycarbonylamino)piperidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- B3660
- Product name
- (S)-3-(tert-Butoxycarbonylamino)piperidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- B621130
- Product name
- (S)-3-(Boc-amino)piperidine
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- B621130
- Product name
- (S)-3-(Boc-amino)piperidine
- Packaging
- 2.5g
- Price
- $1190
- Updated
- 2021/12/16
(S)-3-N-Boc-aminopiperidine Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
(S)-3-(Boc-amino)piperidine, is used as an intermediate for pigments. It is also used as important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is also an useful intermediate for the synthesis of a variety of chiral aminopiperidinyl quinolones as potent antibacterial agents against resistant pathogens; and alkynylpyrimidine amide derivatives as orally available inhibitors of Tie-2 kinase.
Uses
(S)-3-N-Boc-aminopiperidine can be useful intermediate for the synthesis of a variety of chiral aminopiperidinyl quinolones as potent antibacterial agents against resistant pathogens; and alkynylpyrimidine amide derivatives as orally a vailable inhibitors of Tie-2 kinase.
Synthesis
92235-39-7
216854-23-8
General procedure for the synthesis of (S)-3-Boc-aminopiperidine from tert-butyl (S)-2-piperidone-3-carbamate: to a solution of THF (250 mL) of the product of Example 41A (20.1 g, 94 mmol) was added slowly and dropwise over a period of 45 min at 0 °C a borane-THF complex (162 mL, 1 M solution of THF 162 mmol; purchased from Aldrich). After the dropwise addition was completed, the reaction was kept at 0 °C with continued stirring for 1 hour. Subsequently, the ice bath was removed and the reaction mixture was allowed to stir at 20-25 °C for 6 hours. Upon completion of the reaction, methanol (100 mL) and 5% NaHCO3 solution (300 mL) were carefully added to quench the reaction. The mixture was stirred vigorously for 16 hours and subsequently concentrated under reduced pressure to reduce the volume. The residue was treated with methanol (200 mL), heated to reflux for 30 minutes, and then concentrated again under reduced pressure. This process was repeated twice. The final residue was suspended in 20% K2CO3 solution (200 mL) and extracted with ether (3 x 200 mL). The organic phases were combined, dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio of dichloromethane: methanol: NH4OH = 90:10:1) to afford (S)-3-Boc-aminopiperidine (5.64 g, 30% yield) in white solid form. The mass spectrum (CI/NH3) showed m/z 201 (M + H)+.
References
[1] Patent: EP1428824, 2004, A1. Location in patent: Page 44
(S)-3-N-Boc-aminopiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-3-N-Boc-aminopiperidine manufacturers
- Product
- (S)-3-N-Boc-aminopiperidine 216854-23-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 100G
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-17
- Product
- (S)-3-N-Boc-aminopiperidine 216854-23-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-06