3-N-Boc-Aminomethylpiperidine

Product Name: 3-N-Boc-Aminomethylpiperidine
CAS No.: 142643-29-6
Chemical Name: 3-N-Boc-Aminomethylpiperidine
Synonyms: TERT-BUTYL PIPERIDIN-3-YLCARBAMATE;PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER;3-BOC-AMINOPIPERIDINE;3-BOC-3-AMINOPIPERIDINE;3-BOC-AMINOMETHYL PIPERIDINE;3-N-BOC-AMINOMETHYL PIPERIDINE;3-BOC-AMINOMETHYL PIPERIDINE 98%;(±)-3-(Boc-aminomethyl)piperidine;3-AMINOPIPERIDINE, 3-BOC PROTECTED;(+/-)-3-(BOC-AMINOMETHYL)PIPERIDINE
CBNumber: CB5205644
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: 142643-29-6.mol

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3-N-Boc-Aminomethylpiperidine Property

Melting point:: 60-70 °C(lit.)
Boiling point:: 321.8±15.0 °C(Predicted)
Density: 0.981
storage temp.: 2-8°C
form: solid
pka: 12.71±0.46(Predicted)
color: White
BRN: 7023643
CAS DataBase Reference: 142643-29-6(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 3259 8/PG 2
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 8
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 653896
Product name: 3-(Boc-aminomethyl)piperidine
Purity: 95%
Packaging: 1g
Price: $95
Updated: 2023/06/20

Sigma-Aldrich

Product number: 653896
Product name: 3-(Boc-aminomethyl)piperidine
Purity: 95%
Packaging: 10g
Price: $248
Updated: 2025/07/31

TRC

Product number: B630105
Product name: 3-N-Boc-aminomethylPiperidine
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Activate Scientific

Product number: AS20964
Product name: 3-(Boc-aminomethyl)piperidine
Purity: 97%
Packaging: 1g
Price: $28
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-J3
Product name: 3-(Aminomethyl)piperidine, 3-Boc protected
Purity: 97%
Packaging: 1g
Price: $39
Updated: 2021/12/16

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3-N-Boc-Aminomethylpiperidine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Reagent for:

Preparation of 9-substituted phenanthrene-based tylophorine analogs
Enzymatic acylation

Uses

Reagent for:
Preparation of Tylophorine analogs
Enzymatic acylation

Synthesis

220031-61-8

142643-29-6

To a solution of tert-butyl (1-benzylpiperidin-3-yl)methylcarbamate (2.05 g, 6.74 mmol, 1.0 equiv) in methanol (40 mL) was added 10% Pd(OH)2/C (0.21 g, 10 wt%). Cyclohexene (6.80 mL, 67.40 mmol, 10.0 eq.) was added to the reaction system under argon protection. The resulting suspension was refluxed under argon atmosphere for 20 hours. Upon completion of the reaction, it was filtered through a Celite pad (Celite 577 fine) and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography with the eluent of dichloromethane/methanol/triethylamine (3:1:0.1, v/v/v) to afford 1.31 g of the target compound 3-Boc-aminomethylpiperidine as a colorless viscous oil. Yield: 91%; Thin Layer Chromatography Rf = 0.33 (dichloromethane/methanol/triethylamine = 3:1:0.1); 1H NMR (400 MHz, CDCl3) δ: 1.08 (qd, J = 11.2, 4.0 Hz, 1H, CH2CHAHBCH), 1.42 (s, 9H, 3 x CH3), 1.45-1.52 (m, 1H. CHAHBCH2CH), 1.58-1.70 (m, 2H, CHAHBCHAHBCH), 1.76-1.82 (m, 1H, CH), 2.32 (t, J = 11.2 Hz, 1H, NHCHAHBCH), 2.52-2.60 (m, 2H, CH2CHAHBNH), 2.97-3.03 (m, 3H, CH2NHCOHBCH), 2.97-3.03 (m, 3H, CH2NHCOHBCH), 2.97-3.03 (m, 3H, CH2NHCO 3H, CH2NHCO + CH2CHAHBNH), 3.06 (dd, J = 11.6, 3.2 Hz, 1H, NHCHAHBCH), 4.63 (br s, 1H, NHCO); 13C NMR (100 MHz, CDCl3) δ: 24.99, 27.97, 28.27, 36.86, 43.74, 45.90, 49.54, 78.28, 155.86; ESI-HRMS m/z calculated C11H23N2O2 [M+H]+ 215.1760, measured 215.1763; IR (KBr) υ: 3385, 2978, 2934, 1685, 1528, 1458, 1367, 1272, 1254, 1174, 1009 cm-1 1174, 1009 cm-1.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4442 - 4452
[2] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 2, p. 633 - 645
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 1, p. 119 - 139

3-N-Boc-Aminomethylpiperidine Preparation Products And Raw materials

Raw materials

L-Glutamic acid dimethyl ester hydrochloride acetonitrile Hexane Ammonium hydroxide Ethanol Calcium chloride Di-tert-butyl dicarbonate Potassium carbonate Sodium borohydride Triethylamine Methanesulfonyl chloride 1,4-Dioxane Ethyl acetate Sodium bicarbonate Dichloromethane Magnesium sulfate Citric acid

Preparation Products

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3-N-Boc-Aminomethylpiperidine Suppliers

Canada 1 China 107 Europe 1 France 2 Germany 3 India 2 Switzerland 2 Ukraine 1 United Kingdom 9 United States 32 Global 160

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View Lastest Price from 3-N-Boc-Aminomethylpiperidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3-N-Boc-Aminomethylpiperidine 142643-29-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-22

Career Henan Chemical Co

Product: 3-N-Boc-Aminomethylpiperidine 142643-29-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

142643-29-6, 3-N-Boc-AminomethylpiperidineRelated Search:

4-(Aminomethyl)piperidine 2,2,6,6-Tetramethyl-4-piperidinol 2-PIPERIDYLMETHYLAMINE Haloperidol Cyhalofop-butyl Buprofezin 2-Butoxyethanol TRIMETHYLPHOSPHINE OXIDE Butyl acetate Diethylene glycol monobutyl ether tert-Butyl peroxyacetate Chlorpropham tert-Butyl acetate tert-Butanol 2-(Boc-aminomethyl)-piperidine 4-(Boc-Aminomethyl)piperidine Butyl acrylate 2-Boc-aminomethylpyrrolidine

3-N-BOC-AMINOMETHYL PIPERIDINE

1,1-diMethylethyl [(piperidin-3-yl)-Methyl]carbaMate

tert-Butyl [(piperidin-3-yl)methyl]carbamate, 3-{[(tert-Butoxycarbonyl)amino]methyl}piperidine

(3-Piperidinylmethyl)-carbamic acid 1,1-dimethylethyl ester

Carbamic acid, N-(3-piperidinylmethyl)-, 1,1-dimethylethyl ester

(+/-)-3-(Boc-aminomethyl)piperidine >=98.0% (TLC)

tert-butyl N-(piperidin-3-ylmethyl)carbamate

3-AMINOPIPERIDINE, 3-BOC PROTECTED

(3-AMINOMETHYL, N-BOC PROTECTED)PIPERIDINE

(+/-)-3-(BOC-AMINOMETHYL)PIPERIDINE

3-BOC-AMINOMETHYL PIPERIDINE

3-BOC-AMINOPIPERIDINE

TERT-BUTYL (PIPERIDIN-3-YLMETHYL) CARBAMATE

TERT-BUTYL N-(3-PIPERIDYLMETHYL)CARBAMATE

TERT-BUTYL PIPERIDIN-3-YLCARBAMATE

(S)-PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER

(R,S)-(BOC-3-AMINOMETHYL)-PIPERIDINE

(R)-PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER

PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER

PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER

CARBAMIC ACID, 3-PIPERIDINYL-, 1,1-DIMETHYLETHYL ESTER

3-Aminopiperidine, 3-BOC protected 97%

3-BOC-3-AMINOPIPERIDINE

3-BOC-AMINOMETHYL PIPERIDINE 98%

(Piperidin-3-ylmethyl) carbamic acid tert-butyl ester, tert-Butyl (piperidin-3-ylmethyl) carbamate

3-(Aminomethyl)piperidine, 3-BOC protected

tert-butyl (piperidin-3-ylmethyl)carbamate(SALTDATA: FREE)

(R,S)-3-(Boc-aminomethyl)-piperidine

N-[(3S)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

Carbamic acid, (3-piperidinylmethyl)-, 1,1-dimethylethyl ester

(^+)-3-(Boc-aminomethyl)piperidine,98%

(±)-3-(Boc-aminomethyl)piperidine

(±)-3-(Boc-aminomethyl)piperidine, CAS 142643-29-6

3-(Boc-aminomethyl)piperidine - [A12322]

142643-29-6

142643-23-6

C5H10NCH2NHCO2C4H9

Piperidines

Heterocyclic Building Blocks

Building Blocks

pharmacetical

Amines

Pyrans, Piperidines &Piperazines

Piperidine

API intermediates

Pyrans, Piperidines & Piperazines