ChemicalBook > CAS DataBase List > 3-N-Boc-Aminomethylpiperidine

3-N-Boc-Aminomethylpiperidine

Product Name
3-N-Boc-Aminomethylpiperidine
CAS No.
142643-29-6
Chemical Name
3-N-Boc-Aminomethylpiperidine
Synonyms
TERT-BUTYL PIPERIDIN-3-YLCARBAMATE;PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER;3-BOC-AMINOPIPERIDINE;3-BOC-3-AMINOPIPERIDINE;3-BOC-AMINOMETHYL PIPERIDINE;3-N-BOC-AMINOMETHYL PIPERIDINE;3-BOC-AMINOMETHYL PIPERIDINE 98%;(±)-3-(Boc-aminomethyl)piperidine;3-AMINOPIPERIDINE, 3-BOC PROTECTED;(+/-)-3-(BOC-AMINOMETHYL)PIPERIDINE
CBNumber
CB5205644
Molecular Formula
C11H22N2O2
Formula Weight
214.3
MOL File
142643-29-6.mol
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3-N-Boc-Aminomethylpiperidine Property

Melting point:
60-70 °C(lit.)
Boiling point:
321.8±15.0 °C(Predicted)
Density 
0.981
storage temp. 
2-8°C
form 
solid
pka
12.71±0.46(Predicted)
color 
White
BRN 
7023643
CAS DataBase Reference
142643-29-6(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3259 8/PG 2
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
8
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
653896
Product name
3-(Boc-aminomethyl)piperidine
Purity
95%
Packaging
1g
Price
$95
Updated
2023/06/20
Sigma-Aldrich
Product number
653896
Product name
3-(Boc-aminomethyl)piperidine
Purity
95%
Packaging
10g
Price
$248
Updated
2025/07/31
TRC
Product number
B630105
Product name
3-N-Boc-aminomethylPiperidine
Packaging
250mg
Price
$70
Updated
2021/12/16
Activate Scientific
Product number
AS20964
Product name
3-(Boc-aminomethyl)piperidine
Purity
97%
Packaging
1g
Price
$28
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-J3
Product name
3-(Aminomethyl)piperidine, 3-Boc protected
Purity
97%
Packaging
1g
Price
$39
Updated
2021/12/16
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3-N-Boc-Aminomethylpiperidine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Reagent for:

  • Preparation of 9-substituted phenanthrene-based tylophorine analogs
  • Enzymatic acylation

Uses

Reagent for:
Preparation of Tylophorine analogs
Enzymatic acylation

Synthesis

220031-61-8

142643-29-6

To a solution of tert-butyl (1-benzylpiperidin-3-yl)methylcarbamate (2.05 g, 6.74 mmol, 1.0 equiv) in methanol (40 mL) was added 10% Pd(OH)2/C (0.21 g, 10 wt%). Cyclohexene (6.80 mL, 67.40 mmol, 10.0 eq.) was added to the reaction system under argon protection. The resulting suspension was refluxed under argon atmosphere for 20 hours. Upon completion of the reaction, it was filtered through a Celite pad (Celite 577 fine) and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography with the eluent of dichloromethane/methanol/triethylamine (3:1:0.1, v/v/v) to afford 1.31 g of the target compound 3-Boc-aminomethylpiperidine as a colorless viscous oil. Yield: 91%; Thin Layer Chromatography Rf = 0.33 (dichloromethane/methanol/triethylamine = 3:1:0.1); 1H NMR (400 MHz, CDCl3) δ: 1.08 (qd, J = 11.2, 4.0 Hz, 1H, CH2CHAHBCH), 1.42 (s, 9H, 3 x CH3), 1.45-1.52 (m, 1H. CHAHBCH2CH), 1.58-1.70 (m, 2H, CHAHBCHAHBCH), 1.76-1.82 (m, 1H, CH), 2.32 (t, J = 11.2 Hz, 1H, NHCHAHBCH), 2.52-2.60 (m, 2H, CH2CHAHBNH), 2.97-3.03 (m, 3H, CH2NHCOHBCH), 2.97-3.03 (m, 3H, CH2NHCOHBCH), 2.97-3.03 (m, 3H, CH2NHCO 3H, CH2NHCO + CH2CHAHBNH), 3.06 (dd, J = 11.6, 3.2 Hz, 1H, NHCHAHBCH), 4.63 (br s, 1H, NHCO); 13C NMR (100 MHz, CDCl3) δ: 24.99, 27.97, 28.27, 36.86, 43.74, 45.90, 49.54, 78.28, 155.86; ESI-HRMS m/z calculated C11H23N2O2 [M+H]+ 215.1760, measured 215.1763; IR (KBr) υ: 3385, 2978, 2934, 1685, 1528, 1458, 1367, 1272, 1254, 1174, 1009 cm-1 1174, 1009 cm-1.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4442 - 4452
[2] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 2, p. 633 - 645
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 1, p. 119 - 139

3-N-Boc-Aminomethylpiperidine Preparation Products And Raw materials

Raw materials

L-Glutamic acid dimethyl ester hydrochloride acetonitrile Hexane Ammonium hydroxide Ethanol Calcium chloride Di-tert-butyl dicarbonate Potassium carbonate Sodium borohydride Triethylamine Methanesulfonyl chloride 1,4-Dioxane Ethyl acetate Sodium bicarbonate Dichloromethane Magnesium sulfate Citric acid

Preparation Products

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View Lastest Price from 3-N-Boc-Aminomethylpiperidine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
3-N-Boc-Aminomethylpiperidine 142643-29-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-22
Career Henan Chemical Co
Product
3-N-Boc-Aminomethylpiperidine 142643-29-6
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500KG
Release date
2018-08-19

142643-29-6, 3-N-Boc-AminomethylpiperidineRelated Search:

4-(Aminomethyl)piperidine 2,2,6,6-Tetramethyl-4-piperidinol 2-PIPERIDYLMETHYLAMINE Haloperidol Cyhalofop-butyl Buprofezin 2-Butoxyethanol TRIMETHYLPHOSPHINE OXIDE Butyl acetate Diethylene glycol monobutyl ether tert-Butyl peroxyacetate Chlorpropham tert-Butyl acetate tert-Butanol 2-(Boc-aminomethyl)-piperidine 4-(Boc-Aminomethyl)piperidine Butyl acrylate 2-Boc-aminomethylpyrrolidine

  • 3-N-BOC-AMINOMETHYL PIPERIDINE
  • 1,1-diMethylethyl [(piperidin-3-yl)-Methyl]carbaMate
  • tert-Butyl [(piperidin-3-yl)methyl]carbamate, 3-{[(tert-Butoxycarbonyl)amino]methyl}piperidine
  • (3-Piperidinylmethyl)-carbamic acid 1,1-dimethylethyl ester
  • Carbamic acid, N-(3-piperidinylmethyl)-, 1,1-dimethylethyl ester
  • (+/-)-3-(Boc-aminomethyl)piperidine >=98.0% (TLC)
  • tert-butyl N-(piperidin-3-ylmethyl)carbamate
  • 3-AMINOPIPERIDINE, 3-BOC PROTECTED
  • (3-AMINOMETHYL, N-BOC PROTECTED)PIPERIDINE
  • (+/-)-3-(BOC-AMINOMETHYL)PIPERIDINE
  • 3-BOC-AMINOMETHYL PIPERIDINE
  • 3-BOC-AMINOPIPERIDINE
  • TERT-BUTYL (PIPERIDIN-3-YLMETHYL) CARBAMATE
  • TERT-BUTYL N-(3-PIPERIDYLMETHYL)CARBAMATE
  • TERT-BUTYL PIPERIDIN-3-YLCARBAMATE
  • (S)-PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
  • (R,S)-(BOC-3-AMINOMETHYL)-PIPERIDINE
  • (R)-PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
  • PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
  • PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
  • CARBAMIC ACID, 3-PIPERIDINYL-, 1,1-DIMETHYLETHYL ESTER
  • 3-Aminopiperidine, 3-BOC protected 97%
  • 3-BOC-3-AMINOPIPERIDINE
  • 3-BOC-AMINOMETHYL PIPERIDINE 98%
  • (Piperidin-3-ylmethyl) carbamic acid tert-butyl ester, tert-Butyl (piperidin-3-ylmethyl) carbamate
  • 3-(Aminomethyl)piperidine, 3-BOC protected
  • tert-butyl (piperidin-3-ylmethyl)carbamate(SALTDATA: FREE)
  • (R,S)-3-(Boc-aminomethyl)-piperidine
  • N-[(3S)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
  • Carbamic acid, (3-piperidinylmethyl)-, 1,1-dimethylethyl ester
  • (^+)-3-(Boc-aminomethyl)piperidine,98%
  • (±)-3-(Boc-aminomethyl)piperidine
  • (±)-3-(Boc-aminomethyl)piperidine, CAS 142643-29-6
  • 3-(Boc-aminomethyl)piperidine - [A12322]
  • 142643-29-6
  • 142643-23-6
  • C5H10NCH2NHCO2C4H9
  • Piperidines
  • Heterocyclic Building Blocks
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  • pharmacetical
  • Amines
  • Pyrans, Piperidines &Piperazines
  • Piperidine
  • API intermediates
  • Pyrans, Piperidines & Piperazines