L-Glutamic acid dimethyl ester hydrochloride

Product Name: L-Glutamic acid dimethyl ester hydrochloride
CAS No.: 23150-65-4
Chemical Name: L-Glutamic acid dimethyl ester hydrochloride
Synonyms: DIMETHYL L-GLUTAMATE HYDROCHLORIDE;PF-1;Glu(Ome)2.Hcl;GLU(OME)-OMEHCL;H-GLU(OME)-OME HCL;L-Glu(OMe)-OMe·HCl;H-L-Glu(Me)-OMe*HCl;L-Glutamic acid dime;DiMethyl-L-GlutaMate;H-L-Glu(OMe)-OMe.HCl
CBNumber: CB0682345
Molecular Formula: C7H14ClNO4
Formula Weight: 211.64
MOL File: 23150-65-4.mol

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L-Glutamic acid dimethyl ester hydrochloride Property

Melting point:: 89-90°C
alpha: 26 º (c=5% in H2O)
refractive index: 26 ° (C=5, H2O)
storage temp.: 2-8°C
solubility: Methanol, Water
form: Powder
color: White
optical activity: [α]20/D +26.0±1°, c = 5% in H2O
Water Solubility: Soluble in water, methanol (50 mg/ml).
Sensitive: Hygroscopic
BRN: 4238829
Stability:: Hygroscopic
InChI: InChI=1/C7H13NO4.ClH/c1-11-6(9)4-3-5(8)7(10)12-2;/h5H,3-4,8H2,1-2H3;1H/t5-;/s3
InChIKey: MFUPLHQOVIUESQ-JEDNCBNOSA-N
SMILES: [C@@H](N)(C(=O)OC)CCC(=O)OC.Cl |&1:0,r|
CAS DataBase Reference: 23150-65-4(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 49560
Product name: L-Glutamic acid dimethyl ester hydrochloride
Purity: ≥99.0% (dried material, AT)
Packaging: 10g
Price: $94.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 49560
Product name: L-Glutamic acid dimethyl ester hydrochloride
Purity: ≥99.0% (dried material, AT)
Packaging: 50g
Price: $303
Updated: 2025/07/31

TCI Chemical

Product number: D3353
Product name: Dimethyl L-Glutamate Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 5g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: D3353
Product name: Dimethyl L-Glutamate Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 25g
Price: $150
Updated: 2025/07/31

Usbiological

Product number: 239245
Product name: L-Glutamic acid dimethyl ester hydrochloride 98+%
Packaging: 5g
Price: $156
Updated: 2021/12/16

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L-Glutamic acid dimethyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

L-Glutamic Acid Dimethyl Ester is a diester analogue of L-Glutamic Acid, a non-essential amino acid. L-Glutamic Acid Dimethyl Ester has been shown to antagonize the effects of morphine sulfate.

Uses

L-Glutamic acid dimethyl ester hydrochloride is used as a pharmaceutical intermediate.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

56-86-0

23150-65-4

To a 500 mL four-necked flask equipped with a stirrer, thermometer and reflux condenser (connected to a 30% aqueous sodium hydroxide solution absorption unit), 300 g of methanol, 14.7 g (0.10 mol) of L-glutamic acid, and 30.0 g (0.25 mol) of thionyl chloride were added sequentially. The reaction mixture was heated to 60-63 °C and the reaction was stirred at this temperature for 7 hours. Upon completion of the reaction, the system was cooled to 20-25 °C, followed by the passage of nitrogen to displace the hydrogen chloride gas in the system for 30 min. Next, the excess thionyl chloride and methanol were recovered by distillation. To the residue, 100 g of methyl tert-butyl ether was added and pulped, followed by filtration to collect the solid. Upon drying, 20.8 g of L-glutamic acid dimethyl ester hydrochloride was obtained as a white solid. The product was analyzed by high performance liquid chromatography (HPLC) with 99.5% purity and 98.1% yield.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 24, p. 6144 - 6153
[2] Archiv der Pharmazie, 2005, vol. 338, # 5-6, p. 281 - 290
[3] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 18, p. 6273 - 6290
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 2, p. 777 - 793
[5] Patent: CN107602436, 2018, A. Location in patent: Paragraph 0053; 0054

L-Glutamic acid dimethyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

3-N-Boc-Aminomethylpiperidine

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L-Glutamic acid dimethyl ester hydrochloride Suppliers

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View Lastest Price from L-Glutamic acid dimethyl ester hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: L-Glutamic acid dimethyl ester hydrochloride 23150-65-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 1000kg/month
Release date: 2021-12-13

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-Glu(OMe)-OMe.HCl 23150-65-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-22

Henan Aochuang Chemical Co.,Ltd.

Product: L-Glutamic acid dimethyl ester hydrochloride 23150-65-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

23150-65-4, L-Glutamic acid dimethyl ester hydrochlorideRelated Search:

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imethyl(2S)-2-aminopentanedioate,hydrochloride

L-GLUTAMIC ACID DIMETHYL ESTER HYDROCHLORIDE 23150-65-4

L-Glutamic acid dimethyl ester hydrochloride USP/EP/BP

H-L-Glu(OMe)-OMe.HCl

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PF-1

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Arginine Impurity(Hydrochloride)

<sc>L</sc>-Glutamic acid dimethyl ester hydrochloride

23150-65-4

C9H17NO4HCl

C9H18NO4Cl

CH3OCOCH2CH2CHNH2COOCH3HCl

C7H14NO4Cl

Specialty Synthesis

Peptide Synthesis

Amino Acid Derivatives

AMINE

Amino Acid Methyl Esters

Protected & Labeled Amino Acids

Amino Acids (C-Protected)