L-Glutamic acid dimethyl ester hydrochloride
- Product Name
- L-Glutamic acid dimethyl ester hydrochloride
- CAS No.
- 23150-65-4
- Chemical Name
- L-Glutamic acid dimethyl ester hydrochloride
- Synonyms
- DIMETHYL L-GLUTAMATE HYDROCHLORIDE;PF-1;Glu(Ome)2.Hcl;GLU(OME)-OMEHCL;H-GLU(OME)-OME HCL;L-Glu(OMe)-OMe·HCl;H-L-Glu(Me)-OMe*HCl;L-Glutamic acid dime;DiMethyl-L-GlutaMate;H-L-Glu(OMe)-OMe.HCl
- CBNumber
- CB0682345
- Molecular Formula
- C7H14ClNO4
- Formula Weight
- 211.64
- MOL File
- 23150-65-4.mol
L-Glutamic acid dimethyl ester hydrochloride Property
- Melting point:
- 89-90°C
- alpha
- 26 º (c=5% in H2O)
- refractive index
- 26 ° (C=5, H2O)
- storage temp.
- 2-8°C
- solubility
- Methanol, Water
- form
- Powder
- color
- White
- optical activity
- [α]20/D +26.0±1°, c = 5% in H2O
- Water Solubility
- Soluble in water, methanol (50 mg/ml).
- Sensitive
- Hygroscopic
- BRN
- 4238829
- Stability:
- Hygroscopic
- InChI
- InChI=1/C7H13NO4.ClH/c1-11-6(9)4-3-5(8)7(10)12-2;/h5H,3-4,8H2,1-2H3;1H/t5-;/s3
- InChIKey
- MFUPLHQOVIUESQ-JEDNCBNOSA-N
- SMILES
- [C@@H](N)(C(=O)OC)CCC(=O)OC.Cl |&1:0,r|
- CAS DataBase Reference
- 23150-65-4(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 49560
- Product name
- L-Glutamic acid dimethyl ester hydrochloride
- Purity
- ≥99.0% (dried material, AT)
- Packaging
- 10g
- Price
- $94.9
- Updated
- 2025/07/31
- Product number
- 49560
- Product name
- L-Glutamic acid dimethyl ester hydrochloride
- Purity
- ≥99.0% (dried material, AT)
- Packaging
- 50g
- Price
- $303
- Updated
- 2025/07/31
- Product number
- D3353
- Product name
- Dimethyl L-Glutamate Hydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 5g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- D3353
- Product name
- Dimethyl L-Glutamate Hydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 25g
- Price
- $150
- Updated
- 2025/07/31
- Product number
- G597098
- Product name
- L-Glutamic acid dimethyl ester hydrochloride
- Packaging
- 2.5g
- Price
- $45
- Updated
- 2021/12/16
L-Glutamic acid dimethyl ester hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Crystalline
Uses
L-Glutamic Acid Dimethyl Ester is a diester analogue of L-Glutamic Acid, a non-essential amino acid. L-Glutamic Acid Dimethyl Ester has been shown to antagonize the effects of morphine sulfate.
Uses
L-Glutamic acid dimethyl ester hydrochloride is used as a pharmaceutical intermediate.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
67-56-1
56-86-0
23150-65-4
To a 500 mL four-necked flask equipped with a stirrer, thermometer and reflux condenser (connected to a 30% aqueous sodium hydroxide solution absorption unit), 300 g of methanol, 14.7 g (0.10 mol) of L-glutamic acid, and 30.0 g (0.25 mol) of thionyl chloride were added sequentially. The reaction mixture was heated to 60-63 °C and the reaction was stirred at this temperature for 7 hours. Upon completion of the reaction, the system was cooled to 20-25 °C, followed by the passage of nitrogen to displace the hydrogen chloride gas in the system for 30 min. Next, the excess thionyl chloride and methanol were recovered by distillation. To the residue, 100 g of methyl tert-butyl ether was added and pulped, followed by filtration to collect the solid. Upon drying, 20.8 g of L-glutamic acid dimethyl ester hydrochloride was obtained as a white solid. The product was analyzed by high performance liquid chromatography (HPLC) with 99.5% purity and 98.1% yield.
References
[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 24, p. 6144 - 6153
[2] Archiv der Pharmazie, 2005, vol. 338, # 5-6, p. 281 - 290
[3] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 18, p. 6273 - 6290
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 2, p. 777 - 793
[5] Patent: CN107602436, 2018, A. Location in patent: Paragraph 0053; 0054
L-Glutamic acid dimethyl ester hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
L-Glutamic acid dimethyl ester hydrochloride Suppliers
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View Lastest Price from L-Glutamic acid dimethyl ester hydrochloride manufacturers
- Product
- L-Glutamic acid dimethyl ester hydrochloride 23150-65-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 1000kg/month
- Release date
- 2021-12-13
- Product
- H-L-Glu(OMe)-OMe.HCl 23150-65-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-22
- Product
- L-Glutamic acid dimethyl ester hydrochloride 23150-65-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17