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L-Glutamic acid di-tert-butyl ester hydrochloride

Product Name
L-Glutamic acid di-tert-butyl ester hydrochloride
CAS No.
32677-01-3
Chemical Name
L-Glutamic acid di-tert-butyl ester hydrochloride
Synonyms
Di-tert-butyl L-glutamate hydrochloride;H-GLU(OTBU)-OTBU HCL;H-GLU(OBUT)-OBUT·HCL;H-L-Glu(Tbu;Glu(OtBu)-OtBu;H-Glu(OBut)-OBut;Glu(OtBu)-OtBuCl;L-Glu(OtBu)2.HCl;GLU(OTBU)-OTBU.HCL;H-GLU(OBUT)-OBUT HCL
CBNumber
CB8460202
Molecular Formula
C13H26ClNO4
Formula Weight
295.8
MOL File
32677-01-3.mol
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L-Glutamic acid di-tert-butyl ester hydrochloride Property

Melting point:
133-135 °C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in methanol (50gmg/ml).
form 
Solid
color 
White to Off-White
BRN 
3573738
CAS DataBase Reference
32677-01-3(CAS DataBase Reference)
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Safety

WGK Germany 
3
RTECS 
MA0880000
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G7501
Product name
L-Glutamic acid di-tert-butyl ester hydrochloride
Packaging
1g
Price
$131
Updated
2025/07/31
Sigma-Aldrich
Product number
G7501
Product name
L-Glutamic acid di-tert-butyl ester hydrochloride
Packaging
5g
Price
$442
Updated
2025/07/31
TCI Chemical
Product number
D6026
Product name
H-Glu(OtBu)-OtBu·HCl
Packaging
5G
Price
$56
Updated
2025/07/31
TCI Chemical
Product number
D6026
Product name
H-Glu(OtBu)-OtBu·HCl
Packaging
25G
Price
$168
Updated
2025/07/31
TRC
Product number
D493735
Product name
Di-tert-butylGlutamateHydrochloride
Packaging
5g
Price
$95
Updated
2021/12/16
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L-Glutamic acid di-tert-butyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

L-Glutamic acid di-tert-butyl ester may be useful in the synthesis of substance P antagonistic peptides.

Biological Activity

Glutamic acid di-tert butyl ester (GTBE) possesses convulsant properties in mice and rats. It might have unique pharmacological features th at set it apart from other convulsant medications.', 'L-Glutamic acid di-tert-butyl ester is C-terminal and R-chain blocked derivative of L-glutamate th at may be useful in the synthesis of substance P antagonistic peptides.

Synthesis

617-65-2

115-11-7

32677-01-3

Example 5 Synthesis of L-glutamic acid di-tert-butyl ester hydrochloride (15A): L-glutamic acid (14) (4.4 g, 30 mmol) was suspended in chloroform (120 mL) and concentrated sulfuric acid (3 mL, 56 mmol) was added. The suspension was cooled to -78 °C, followed by the slow addition of liquefied isobutene (70 mL). The reaction mixture was gradually warmed to room temperature with stirring and the reaction was continued for 18 hours. Upon completion of the reaction, the suspended solids were completely dissolved to form a clarified solution. The solution was bubbled with nitrogen gas for 10 min to remove the residual isobutene, followed by washing with saturated aqueous NaHCO3 solution (2 x 100 mL) and distilled water (100 mL) in that order. The organic layer was dried over anhydrous MgSO4 and concentrated under reduced pressure to remove the solvent. The crude product was placed in a desiccator and dried in the presence of NaOH particles for 48 h to give L-glutamic acid di-tert-butyl ester (15) (6.7 g, 86% yield) as an oil.1H-NMR (δH): 1.39 (s, 9H, COO-t-Bu), 1.41 (s, 9H, COO-t-Bu), 1.60-1.90 (m, 2H CH2CH(NH2)-), 2.15-2.35 (m, 2H, CH2COO), 2.85 (s, 2H, NH2), 3.20-3.35 (m, 1H, CH(NH2)-).MS (ESI): m/z 260 ([M+H]+, 100%), 283 ([M+Na]+, 10%).

in vivo

H-Glu (OtBu)-OtBu hydrochloride can be used to synthesize PSMA probe 5, which was then labeled with 18F under Al catalysis for tumor imaging (radioactive probe [Al18F]5). [Al18F]5 (0.3-0.4 mCi; 1 hour after injection) shows PC3-PIP tumor uptake of 4.6% ID/g in PET imaging experiments, with a background as low as 0.04% ID/g[2].

References

[1] Patent: US2004/87813, 2004, A1

L-Glutamic acid di-tert-butyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Glutamic acid di-tert-butyl ester hydrochloride Suppliers

China 236 Europe 2 Germany 6 India 5 Japan 4 South Korea 1 Switzerland 2 United Kingdom 11 United States 28 Global 295
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD
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View Lastest Price from L-Glutamic acid di-tert-butyl ester hydrochloride manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-L-Glu(OtBu)-OtBuHCl 32677-01-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-27
Sichuan Jiaying Lai Technology Co.,LTD
Product
H-Glu(OtBu)-OtBuHCl 32677-01-3
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-25
Career Henan Chemical Co
Product
L-Glutamic acid di-tert-butyl ester hydrochloride 32677-01-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15

32677-01-3, L-Glutamic acid di-tert-butyl ester hydrochlorideRelated Search:

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  • C13H26ClNO4
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  • Modified Amino Acids
  • Specialty Synthesis
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  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • BioChemical
  • A - H
  • Amino Acid Derivatives
  • Amino Acids
  • Glutamic acid [Glu, E]
  • Amino Acids and Derivatives
  • Amino hydrochloride