ChemicalBook > CAS DataBase List > L-Glutamic acid dimethyl ester hydrochloride

L-Glutamic acid dimethyl ester hydrochloride

Product Name
L-Glutamic acid dimethyl ester hydrochloride
CAS No.
23150-65-4
Chemical Name
L-Glutamic acid dimethyl ester hydrochloride
Synonyms
DIMETHYL L-GLUTAMATE HYDROCHLORIDE;PF-1;Glu(Ome)2.Hcl;GLU(OME)-OMEHCL;H-GLU(OME)-OME HCL;L-Glu(OMe)-OMe·HCl;H-L-Glu(Me)-OMe*HCl;L-Glutamic acid dime;DiMethyl-L-GlutaMate;H-L-Glu(OMe)-OMe.HCl
CBNumber
CB0682345
Molecular Formula
C7H14ClNO4
Formula Weight
211.64
MOL File
23150-65-4.mol
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L-Glutamic acid dimethyl ester hydrochloride Property

Melting point:
89-90°C
alpha 
26 º (c=5% in H2O)
refractive index 
26 ° (C=5, H2O)
storage temp. 
2-8°C
solubility 
Methanol, Water
form 
Powder
color 
White
optical activity
[α]20/D +26.0±1°, c = 5% in H2O
Water Solubility 
Soluble in water, methanol (50 mg/ml).
Sensitive 
Hygroscopic
BRN 
4238829
Stability:
Hygroscopic
InChI
InChI=1/C7H13NO4.ClH/c1-11-6(9)4-3-5(8)7(10)12-2;/h5H,3-4,8H2,1-2H3;1H/t5-;/s3
InChIKey
MFUPLHQOVIUESQ-JEDNCBNOSA-N
SMILES
[C@@H](N)(C(=O)OC)CCC(=O)OC.Cl |&1:0,r|
CAS DataBase Reference
23150-65-4(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
49560
Product name
L-Glutamic acid dimethyl ester hydrochloride
Purity
≥99.0% (dried material, AT)
Packaging
10g
Price
$94.9
Updated
2025/07/31
Sigma-Aldrich
Product number
49560
Product name
L-Glutamic acid dimethyl ester hydrochloride
Purity
≥99.0% (dried material, AT)
Packaging
50g
Price
$303
Updated
2025/07/31
TCI Chemical
Product number
D3353
Product name
Dimethyl L-Glutamate Hydrochloride
Purity
>98.0%(N)(T)
Packaging
5g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
D3353
Product name
Dimethyl L-Glutamate Hydrochloride
Purity
>98.0%(N)(T)
Packaging
25g
Price
$150
Updated
2025/07/31
TRC
Product number
G597098
Product name
L-Glutamic acid dimethyl ester hydrochloride
Packaging
2.5g
Price
$45
Updated
2021/12/16
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L-Glutamic acid dimethyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

L-Glutamic Acid Dimethyl Ester is a diester analogue of L-Glutamic Acid, a non-essential amino acid. L-Glutamic Acid Dimethyl Ester has been shown to antagonize the effects of morphine sulfate.

Uses

L-Glutamic acid dimethyl ester hydrochloride is used as a pharmaceutical intermediate.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

56-86-0

23150-65-4

To a 500 mL four-necked flask equipped with a stirrer, thermometer and reflux condenser (connected to a 30% aqueous sodium hydroxide solution absorption unit), 300 g of methanol, 14.7 g (0.10 mol) of L-glutamic acid, and 30.0 g (0.25 mol) of thionyl chloride were added sequentially. The reaction mixture was heated to 60-63 °C and the reaction was stirred at this temperature for 7 hours. Upon completion of the reaction, the system was cooled to 20-25 °C, followed by the passage of nitrogen to displace the hydrogen chloride gas in the system for 30 min. Next, the excess thionyl chloride and methanol were recovered by distillation. To the residue, 100 g of methyl tert-butyl ether was added and pulped, followed by filtration to collect the solid. Upon drying, 20.8 g of L-glutamic acid dimethyl ester hydrochloride was obtained as a white solid. The product was analyzed by high performance liquid chromatography (HPLC) with 99.5% purity and 98.1% yield.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 24, p. 6144 - 6153
[2] Archiv der Pharmazie, 2005, vol. 338, # 5-6, p. 281 - 290
[3] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 18, p. 6273 - 6290
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 2, p. 777 - 793
[5] Patent: CN107602436, 2018, A. Location in patent: Paragraph 0053; 0054

L-Glutamic acid dimethyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

3-N-Boc-Aminomethylpiperidine
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View Lastest Price from L-Glutamic acid dimethyl ester hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Glutamic acid dimethyl ester hydrochloride 23150-65-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
1000kg/month
Release date
2021-12-13
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-L-Glu(OMe)-OMe.HCl 23150-65-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-22
Henan Aochuang Chemical Co.,Ltd.
Product
L-Glutamic acid dimethyl ester hydrochloride 23150-65-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17

23150-65-4, L-Glutamic acid dimethyl ester hydrochlorideRelated Search:

Dimethyl sulfoxide Topotecan hydrochloride Dimethyl sulfate Dimethyl phosphite Dimethyl phthalate ETHANE Dimethyl ether Dimethyl fumarate L-Glutamic acid di-tert-butyl ester hydrochloride L-Glutamic acid 5-tert-butyl 1-methyl ester hydrochloride Dimethyl carbonate L-(+)-Glutamic acid hydrochloride L-Glutamic acid Dimethyl oxalate Dacthal N,N-Dimethylformamide Dimethyl adipate Diethyl L-glutamate hydrochloride

  • H-GLU(OME)-OME HCL
  • GLUTAMIC ACID(OME)-OME HCL
  • Dimethyl L-glutamate hydrochloride~H-Glu(OMe)-OMe.HCl
  • dimethyl L-2-aminoglutarate hydrochloride
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  • L-Glutamic Acid Dimethyl Ester HCl
  • DimethylL-glutamateHCl~H-Glu(OMe)-OMe.HCl
  • GLU(OME)-OMEHCL
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  • L-Glutamic acid di-methy ester hydrochloride
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  • Glu(Ome)2.Hcl
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  • L-Glutamic acid dimethyl ester hydrochloride ,99%
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  • DiMethyl-L-GlutaMate
  • (S)-DiMethyl 2-aMinopentanedioate hydrochloride
  • L-Glutamic Acid Dimethyl Ester Hydrochloride H-Glu(OMe)-OMe.HCl
  • L-GlutaMic acid diMethyl ester hydrochloride, 99%, pure
  • diMethyl (2S)-2-aMinopentanedioate hydrochloride
  • L-GlutaMic acid diMethyl ester hydrochlorid
  • L-GlutaMic acid diMethyl es
  • L-GlutaMic acid diMethyl ester hydrochloride >=99.0% (dried Material, AT)
  • DiMethyl L-GlutaMate Hydrochloride , 98.0%(N&T
  • L-Glu(OMe)-OMe·HCl
  • L-Glutamic acid dimethyl ester hydrochloride≥ 98% (HPLC)
  • L-Glutamic acid dimethyleester hydrochloride
  • (S)-DIMETHYL 2-AMINOPENTANEDIOATE HCL
  • Glutamic acid dimethyl ester hydrochloride
  • DIMETHYL L-GLUTAMATE HYDROCHLORIDE
  • L-GLUTAMIC ACID DIMETHYL ESTER HYDROCHLORIDE
  • L-GLUTAMIC ACID-ALPHA,GAMMA-DIMETHYL ESTER HYDROCHLORIDE
  • L-GLUTAMIC ACID ALPHA,GAMMA-DIMETHYL ESTER HYDROCHLORIDE SALT
  • DimethylL-GlutamateHydrochloride&gt
  • L-Glutamic acid, 1,5-dimethyl ester, hydrochloride (1:1)
  • imethyl(2S)-2-aminopentanedioate,hydrochloride
  • L-GLUTAMIC ACID DIMETHYL ESTER HYDROCHLORIDE 23150-65-4
  • L-Glutamic acid dimethyl ester hydrochloride USP/EP/BP
  • H-L-Glu(OMe)-OMe.HCl
  • L-glutamic dimethyl ester hydrochloride
  • PF-1
  • L-Glutaic Acid dimethyl ester.HCL
  • Arginine Impurity(Hydrochloride)
  • <sc>L</sc>-Glutamic acid dimethyl ester hydrochloride
  • 23150-65-4
  • C9H17NO4HCl
  • C9H18NO4Cl
  • CH3OCOCH2CH2CHNH2COOCH3HCl
  • C7H14NO4Cl
  • Specialty Synthesis
  • Peptide Synthesis
  • Amino Acid Derivatives
  • AMINE
  • Amino Acid Methyl Esters
  • Protected & Labeled Amino Acids
  • Amino Acids (C-Protected)