D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL

Product Name: D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
CAS No.: 80938-69-8
Chemical Name: D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
Synonyms: PDMP;DL-PDMP;DL-threo-PDMP;D,L-THREO-PDMP HCL;DL-THREO-PDMP, HYDROCHLORIDE;(+/-)-THREO-PDMP HYDROCHLORIDE;(+)-threo-1-phenyl-2-decanoylamino-3-*morpholino-;(±)-threo-PDMP hydrochloride, PDMP hydrochloride;(+)-THREO-1-PHENYL-2-DECANOYLAMINO-3-*MO RPHOLINO-1-;1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL, HCL
CBNumber: CB5438950
Molecular Formula: C23H39ClN2O3
Formula Weight: 427.03
MOL File: 80938-69-8.mol

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D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Property

storage temp.: -20°C
solubility: DMF: 25 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:5): 0.05 mg/ml
form: White solid

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P7340
Product name: (±)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride
Packaging: 100mg
Price: $464
Updated: 2024/03/01

Sigma-Aldrich

Product number: 513100
Product name: (±)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride
Packaging: 50mg
Price: $272
Updated: 2024/03/01

Cayman Chemical

Product number: 10005276
Product name: DL-threo-PDMP (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 10005276
Product name: DL-threo-PDMP (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $19
Updated: 2021/12/16

Cayman Chemical

Product number: 10005276
Product name: DL-threo-PDMP (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $199
Updated: 2024/03/01

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D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Chemical Properties,Usage,Production

Description

DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-threo-(1R,2R)-PDMP and L-threo-(1S,2S)-PDMP. DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 μM. It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro. The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo-(1R,2R) enantiomer. The D-threo-PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. DL-threo-PDMP increases amyloid-β (1-42) (Aβ42) and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity in HEK293 cells expressing the γ-secretase substrate SC100. [Matreya, LLC. Catalog No. 1719]

Uses

DL-threo-PDMP can deplete cells and mice of their glucosphinolipids.

Biochem/physiol Actions

Glucosylceramide synthase inhibitor; blocks formation of glucosylceramide from ceramide.

D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Suppliers

China 20 India 1 Switzerland 2 United States 5 USA 1 Global 29

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80938-69-8, D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCLRelated Search:

DECANAMIDE D-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL

N-[2-HYDROXY-1-(4-MORPHOLINYLMETHYL)-2-PHENYLETHYL]-DECANAMIDE, MONOHYDROCHLORIDE

(+/-)-THREO-PDMP HYDROCHLORIDE

(+/-)-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HYDROCHLORIDE

1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL, HCL

DL-PDMP

D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL

D,L-THREO-PDMP HCL

DL-THREO-PDMP, HYDROCHLORIDE

(+)-threo-1-phenyl-2-decanoylamino-3-*morpholino-

(+)-THREO-1-PHENYL-2-DECANOYLAMINO-3-*MO RPHOLINO-1-

PDMP HYDROCHLORIDE \ GLUCOSYLCERAMIDE SY NTHASE INHIBITOR

(±)-threo-PDMP hydrochloride, PDMP hydrochloride

PDMP

N-[(1R,2R)-1-hydroxy-3-morpholin-4-yl-1-phenylpropan-2-yl]decanamide:hydrochloride

(±)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol

DL-threo-PDMP, Hydrochloride - CAS 80938-69-8 - Calbiochem

N-[(1R,2R)-1-hydroxy-3-morpholin-4-yl-1-phenylpropan-2-yl]decanamide

DL-threo-PDMP

(+/-)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride

80938-69-8

BioChemical

Biochemicals and Reagents

Glucosylceramide synthase inhibitor

Enzymes, Inhibitors, and Substrates

D to K

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme