3-Hydroxyquinoline
- Product Name
- 3-Hydroxyquinoline
- CAS No.
- 580-18-7
- Chemical Name
- 3-Hydroxyquinoline
- Synonyms
- 3-QUINOLOL;CCRIS 4328;3-Quinolinol;quinolin-3-ol;3-Quinolinol >3-HYDROXYQUINOLINE;3-HYDROXYQUINOLINE 98%;3-Hydroxyquinoline, 95+%;3-HYDROXYQUINOLINE, 97+%;3-Hydroxyquinoline,97%,OR-3952
- CBNumber
- CB5438970
- Molecular Formula
- C9H7NO
- Formula Weight
- 145.16
- MOL File
- 580-18-7.mol
3-Hydroxyquinoline Property
- Melting point:
- 198-202°C
- Boiling point:
- 264.27°C (rough estimate)
- Density
- 1.1555 (rough estimate)
- refractive index
- 1.4500 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 4.28(at 20℃)
- form
- Crystalline Powder
- color
- Beige
- Water Solubility
- 587.9mg/L(20 ºC)
- InChI
- InChI=1S/C9H7NO/c11-8-5-7-3-1-2-4-9(7)10-6-8/h1-6,11H
- InChIKey
- IQQDNMHUOLMLNJ-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2)C=C(O)C=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Q0094
- Product name
- 3-Quinolinol
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $61
- Updated
- 2025/07/31
- Product number
- Q0094
- Product name
- 3-Quinolinol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $190
- Updated
- 2025/07/31
- Product number
- H953140
- Product name
- 3-Hydroxyquinoline
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 072900
- Product name
- 3-Hydroxyquinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 072900
- Product name
- 3-Hydroxyquinoline
- Purity
- 95+%
- Packaging
- 5g
- Price
- $64
- Updated
- 2021/12/16
3-Hydroxyquinoline Chemical Properties,Usage,Production
Chemical Properties
Beige crystalline powder
Uses
3-Hydroxyquinoline is a chemical reagent used in the preparation cyclic peptides with an antitumor functionality. Quinoline derivative as a result of the metabolism by cytochrome P 450.
Synthesis
191162-39-7
580-18-7
General procedure for the synthesis of 3-hydroxyquinoline from quinoline-3-boronic acid: to a round-bottomed flask were added quinoline-3-boronic acid (1.0 mmol), CuSO4-5H2O (0.02 g, 0.1 mmol), CNT-Chit film (10.0 mg), KOH (0.17 g, 3.0 mmol) and deionized water (5.00 mL). The reaction mixture was stirred openly at room temperature for 24 hours. After completion of the reaction, the mixture was filtered and the solids were washed with deionized water. The filtrate was acidified to pH 2-3 with dilute aqueous hydrochloric acid and subsequently extracted with ether (3 x 10 mL). The organic phases were combined and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with an eluent ratio of 70% hexane/30% ethyl acetate (v/v) to afford 3-hydroxyquinoline (0.1433 g, 93% yield) as an off-white solid.
References
[1] Tetrahedron Letters, 2018, vol. 59, # 52, p. 4597 - 4601
[2] Journal of the American Chemical Society, 2018, vol. 140, # 13, p. 4623 - 4631
[3] Organic Letters, 2012, vol. 14, # 13, p. 3494 - 3497
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2536 - 2548
[5] Advanced Synthesis and Catalysis, 2018, vol. 360, # 10, p. 2013 - 2019
3-Hydroxyquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
3-Hydroxyquinoline Suppliers
- Tel
- --
- Fax
- --
- chemist@dalton.com
- Country
- Canada
- ProdList
- 965
- Advantage
- 78
View Lastest Price from 3-Hydroxyquinoline manufacturers
- Product
- 3-Hydroxyquinoline 580-18-7
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 20kg/month
- Release date
- 2019-11-01
- Product
- 3-Hydroxyquinoline 580-18-7
- Price
- US $6.00/KG
- Min. Order
- 2KG
- Purity
- 98%
- Supply Ability
- 1KG,50KG,100KG
- Release date
- 2019-09-03