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3-Hydroxyquinoline

Product Name
3-Hydroxyquinoline
CAS No.
580-18-7
Chemical Name
3-Hydroxyquinoline
Synonyms
3-QUINOLOL;CCRIS 4328;3-Quinolinol;quinolin-3-ol;3-Quinolinol >3-HYDROXYQUINOLINE;3-HYDROXYQUINOLINE 98%;3-Hydroxyquinoline, 95+%;3-HYDROXYQUINOLINE, 97+%;3-Hydroxyquinoline,97%,OR-3952
CBNumber
CB5438970
Molecular Formula
C9H7NO
Formula Weight
145.16
MOL File
580-18-7.mol
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3-Hydroxyquinoline Property

Melting point:
198-202°C
Boiling point:
264.27°C (rough estimate)
Density 
1.1555 (rough estimate)
refractive index 
1.4500 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
4.28(at 20℃)
form 
Crystalline Powder
color 
Beige
Water Solubility 
587.9mg/L(20 ºC)
InChI
InChI=1S/C9H7NO/c11-8-5-7-3-1-2-4-9(7)10-6-8/h1-6,11H
InChIKey
IQQDNMHUOLMLNJ-UHFFFAOYSA-N
SMILES
N1C2C(=CC=CC=2)C=C(O)C=1
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RTECS 
VC4050000
HS Code 
29334990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
Q0094
Product name
3-Quinolinol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$61
Updated
2025/07/31
TCI Chemical
Product number
Q0094
Product name
3-Quinolinol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$190
Updated
2025/07/31
TRC
Product number
H953140
Product name
3-Hydroxyquinoline
Packaging
5g
Price
$110
Updated
2021/12/16
Matrix Scientific
Product number
072900
Product name
3-Hydroxyquinoline
Purity
95+%
Packaging
1g
Price
$14
Updated
2021/12/16
Matrix Scientific
Product number
072900
Product name
3-Hydroxyquinoline
Purity
95+%
Packaging
5g
Price
$64
Updated
2021/12/16
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3-Hydroxyquinoline Chemical Properties,Usage,Production

Chemical Properties

Beige crystalline powder

Uses

3-Hydroxyquinoline is a chemical reagent used in the preparation cyclic peptides with an antitumor functionality. Quinoline derivative as a result of the metabolism by cytochrome P 450.

Synthesis

191162-39-7

580-18-7

General procedure for the synthesis of 3-hydroxyquinoline from quinoline-3-boronic acid: to a round-bottomed flask were added quinoline-3-boronic acid (1.0 mmol), CuSO4-5H2O (0.02 g, 0.1 mmol), CNT-Chit film (10.0 mg), KOH (0.17 g, 3.0 mmol) and deionized water (5.00 mL). The reaction mixture was stirred openly at room temperature for 24 hours. After completion of the reaction, the mixture was filtered and the solids were washed with deionized water. The filtrate was acidified to pH 2-3 with dilute aqueous hydrochloric acid and subsequently extracted with ether (3 x 10 mL). The organic phases were combined and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with an eluent ratio of 70% hexane/30% ethyl acetate (v/v) to afford 3-hydroxyquinoline (0.1433 g, 93% yield) as an off-white solid.

References

[1] Tetrahedron Letters, 2018, vol. 59, # 52, p. 4597 - 4601
[2] Journal of the American Chemical Society, 2018, vol. 140, # 13, p. 4623 - 4631
[3] Organic Letters, 2012, vol. 14, # 13, p. 3494 - 3497
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2536 - 2548
[5] Advanced Synthesis and Catalysis, 2018, vol. 360, # 10, p. 2013 - 2019

3-Hydroxyquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

Solvent Yellow 114
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3-Hydroxyquinoline Suppliers

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View Lastest Price from 3-Hydroxyquinoline manufacturers

Nanjing jinheyou Trading Co., Ltd.
Product
3-Hydroxyquinoline 580-18-7
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
20kg/month
Release date
2019-11-01
Career Henan Chemical Co
Product
3-Hydroxyquinoline 580-18-7
Price
US $6.00/KG
Min. Order
2KG
Purity
98%
Supply Ability
1KG,50KG,100KG
Release date
2019-09-03

580-18-7, 3-HydroxyquinolineRelated Search:

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  • 3-HYDROXYQUINOLINE 98%
  • 3-HYDROXYQUINOLINE, 97+%
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  • CCRIS 4328
  • 3-Hydroxyquinoline, 95+%
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  • 3-Hydroxyquinoline,97%,OR-3952
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  • 580-18-7
  • Heterocyclic Series