ACETYL-DL-CARNITINE HYDROCHLORIDE
- Product Name
- ACETYL-DL-CARNITINE HYDROCHLORIDE
- CAS No.
- 2504-11-2
- Chemical Name
- ACETYL-DL-CARNITINE HYDROCHLORIDE
- Synonyms
- TIMTEC-BB SBB003214;Acetyl-DL-carnitineHCl;acetyldl-carnitinechloride;d,l-acetylcarnitin-chlorid;(+/-)-ACETYLCARNITINE CHLORIDE;ACETYL-DL-CARNITINE HYDROCHLORIDE;acetyl-dl-carnitine hcl crystalline;Acetyl-DL-carnitinehydrochloridecrystalline;(RS)-3-Acetoxy-4-(trimetylammino)butyrate hydrochloride;(2-acetyloxy-3-carboxypropyl)-trimethylazanium,chloride
- CBNumber
- CB5440058
- Molecular Formula
- C9H18ClNO4
- Formula Weight
- 239.7
- MOL File
- 2504-11-2.mol
ACETYL-DL-CARNITINE HYDROCHLORIDE Property
- Melting point:
- 181 - 183°C
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Soluble to 100 mM in water
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 2504-11-2(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- BP2979200
N-Bromosuccinimide Price
- Product number
- A1509
- Product name
- Acetyl-DL-carnitine hydrochloride
- Packaging
- 250mg
- Price
- $165
- Updated
- 2024/03/01
- Product number
- A1509
- Product name
- Acetyl-DL-carnitine hydrochloride
- Packaging
- 1g
- Price
- $469
- Updated
- 2024/03/01
- Product number
- A172003
- Product name
- (±)-AcetylcarnitineChloride
- Packaging
- 100mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- A172003
- Product name
- (±)-AcetylcarnitineChloride
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B6273
- Product name
- (±)-Acetylcarnitinechloride
- Packaging
- 100mg
- Price
- $125
- Updated
- 2021/12/16
ACETYL-DL-CARNITINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
(±)-Acetylcarnitine Chloride is a drug absorption-enhancing agent in the gastrointestinal tract.
Biological Activity
(±)-acetylcarnitine chloride is an agonist for cholinergic.acetylcholine receptor (achr) is an integral membrane protein receptor for acetylcholine. there are two kinds of achrs: nicotinic acetylcholine receptors and muscarinic acetylcholine receptors.(±)-acetylcarnitine chloride is a cholinergic agonist and an intermediate in lipid metabolism [1]. in retinal ganglion cells, acetylcarnitine and acetylcholine inhibited gabaergic responses to exogenous gaba and gabaergic inhibitory postsynaptic currents [2].in dogs with coronary ligation, (-)-carnitine chloride (lcc) (300 mg/kg) and acetyl (-)-carnitine chloride (alcc) (300 mg/kg) inhibited the ventricular arrhythmia. also, lcc and alcc improved oxidative phosphorylation rate and the mitochondrial function [1]. in the mouse hot plate test, acetyl-l-carnitine (alcar) (100 mg/kg) exhibited analgesia. while, u-73122 and neomycin (the phospholipase c (plc) inhibitors) blocked the increase of the pain threshold induced by alcar. licl that impairing phosphatidylinositol synthesis antagonized the antinociception in a dose-dependent way. pma and pdbu (pkc activators) blocked the increase of the pain threshold in a dose-dependent way. these results suggested that alcar analgesia required the participation of the plc-ip3 pathway [3].
Biochem/physiol Actions
Weak cholinergic receptor agonist; intermediate in lipid metabolism.
Purification Methods
Recrystallise the chloride from isopropanol. Dry it over P2O5 under high vacuum. The S-betaine crystallises from EtOH/Et2O with m 145o(dec) and is hygroscopic; it has [] D -19.5o (c 6, H2O). [Krimberg & Wittandt Biochem Z 251 231 1932, Strack et al. Z Physiol Chem 238 191 1936, Beilstein 4 III 1630, 1632.]