4-CARBOMETHOXY-CYCLOHEXANE-1-CARBOXYLIC ACID
- Product Name
- 4-CARBOMETHOXY-CYCLOHEXANE-1-CARBOXYLIC ACID
- CAS No.
- 32529-79-6
- Chemical Name
- 4-CARBOMETHOXY-CYCLOHEXANE-1-CARBOXYLIC ACID
- Synonyms
- m-1015;4-(Methoxycarbonyl);4-CARBOMETHOXY-CYCLOHEXANE-1-CARBOXYLIC ACID;1,4-Cyclohexanedicarboxylic acid, 1-Methyl ester;4-(Methoxycarbonyl)cyclohexane-1-carboxylic acid;1,4-Cyclohexanedicarboxylic acid MonoMethyl ester;4-(Methoxycarbonyl)cyclohexane-1-carboxylic acid, 97%
- CBNumber
- CB5452671
- Molecular Formula
- C9H14O4
- Formula Weight
- 186.21
- MOL File
- 32529-79-6.mol
4-CARBOMETHOXY-CYCLOHEXANE-1-CARBOXYLIC ACID Property
- Melting point:
- 112-114℃
- Boiling point:
- 303.1±35.0℃ (760 Torr)
- Density
- 1.191±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 118.3±19.4℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.66±0.10(Predicted)
- Appearance
- White to off-white Solid
- Water Solubility
- Slightly soluble in water (11 g/L at 25°C).
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2917198090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C177733
- Product name
- 4-Carbomethoxy-cyclohexane-1-carboxylicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 18507
- Product name
- Cis-4-Carbomethoxycyclohexane-1-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $318
- Updated
- 2021/12/16
- Product number
- 34810
- Product name
- 4-Carbomethoxy-cyclohexane-1-carboxylicacid
- Packaging
- 5G
- Price
- $425
- Updated
- 2021/12/16
- Product number
- CHM0390127
- Product name
- 4-(METHOXYCARBONYL)CYCLOHEXANECARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.6
- Updated
- 2021/12/16
- Product number
- 086451
- Product name
- cis-4-Carbomethoxycyclohexane-1-carboxylic acid
- Purity
- >95%
- Packaging
- 5g
- Price
- $578
- Updated
- 2021/12/16
4-CARBOMETHOXY-CYCLOHEXANE-1-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
4-(Methoxycarbonyl)cyclohexane-1-carboxylic acid is used as pharmaceutical intermediate.
Synthesis Reference(s)
Journal of the American Chemical Society, 107, p. 1365, 1985 DOI: 10.1021/ja00291a042
Synthesis
94-60-0
32529-79-6
Step 1. Preparation of 4-(methoxycarbonyl)cyclohexanecarboxylic acid (i-12b). Dimethyl cyclohexane-1,4-dicarboxylate (i-12a) (8 g, 40 mmol) was reacted with barium hydroxide (6.3 g, 20 mmol) in 80% aqueous methanol (150 mL) for 12 h at 25 °C with stirring. Upon completion of the reaction, the mixture was diluted with water (200 mL) and washed with hexane (100 mL x 2) to remove unreacted starting materials. Subsequently, the aqueous layer was acidified to pH=3 with 2M HCl solution and extracted with ethyl acetate (EtOAc) (100mL x 3). The organic layers were combined, washed with water (100 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent ratio: petroleum ether (PE):ethyl acetate (EtOAc) = 50:1 to 3:1) to afford 4-(methoxycarbonyl)cyclohexanecarboxylic acid (3.2 g, 43% yield) as a white solid.LC-MS (ESI) analysis: calculated value of C9H14O4 [M+H]+ was 187, and the measured value was 187.
References
[1] Patent: WO2014/28597, 2014, A2. Location in patent: Page/Page column 54
[2] Patent: US2015/191434, 2015, A1. Location in patent: Paragraph 0294
[3] Liebigs Annalen der Chemie, 1993, # 8, p. 897 - 904
[4] Patent: WO2006/31959, 2006, A1. Location in patent: Page/Page column 13-14
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 6, p. 1752 - 1761
4-CARBOMETHOXY-CYCLOHEXANE-1-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-CARBOMETHOXY-CYCLOHEXANE-1-CARBOXYLIC ACID Suppliers
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View Lastest Price from 4-CARBOMETHOXY-CYCLOHEXANE-1-CARBOXYLIC ACID manufacturers
- Product
- 4-CARBOMETHOXY-CYCLOHEXANE-1-CARBOXYLIC ACID 32529-79-6
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-08