ChemicalBook > CAS DataBase List > 2,6-DIMETHOXYBENZONITRILE

2,6-DIMETHOXYBENZONITRILE

Product Name
2,6-DIMETHOXYBENZONITRILE
CAS No.
16932-49-3
Chemical Name
2,6-DIMETHOXYBENZONITRILE
Synonyms
AKOS 227-44;2,6-DIMETHOXYBENZONI;2,6 methoxybenzonitrile;2,6-dimethoxy-benzonitril;2,6-DIMETHOXYBENZONITRILE;Benzonitrile, 2,6-dimethoxy-;2,6-Dimethoxybenzonitrile,97%;2,6-Dimethoxybenzenecarbonitrile
CBNumber
CB5455607
Molecular Formula
C9H9NO2
Formula Weight
163.17
MOL File
16932-49-3.mol
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2,6-DIMETHOXYBENZONITRILE Property

Melting point:
119-123 °C
Boiling point:
310 °C
Density 
1.2021 (rough estimate)
refractive index 
1.5300 (estimate)
storage temp. 
Sealed in dry,Room Temperature
form 
Crystalline Powder
color 
Light beige
CAS DataBase Reference
16932-49-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22
Safety Statements 
36/37-36-26
Hazard Note 
Irritant
HS Code 
29269095
Toxicity
rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 17, 1953.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R427128
Product name
2,6-DIMETHOXYBENZONITRILE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$185
Updated
2025/07/31
Sigma-Aldrich
Product number
R427128
Product name
2,6-DIMETHOXYBENZONITRILE
Purity
AldrichCPR
Packaging
1G
Price
$179
Updated
2024/03/01
TRC
Product number
D480305
Product name
2,6-Dimethoxybenzonitrile
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4637-1-W4
Product name
2,6-Dimethoxybenzonitrile
Purity
97%
Packaging
10g
Price
$56
Updated
2021/12/16
AK Scientific
Product number
J56451
Product name
2,6-Dimethoxybenzonitrile
Packaging
1g
Price
$10
Updated
2021/12/16
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2,6-DIMETHOXYBENZONITRILE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 293, 1955
Tetrahedron, 49, p. 10843, 1993 DOI: 10.1016/S0040-4020(01)80238-6

Synthesis

68-12-2

151-10-0

16932-49-3

At 0 °C, n-butyllithium (1.67 M hexane solution, 2.9 mL, 4.8 mmol) was slowly added dropwise to a tetrahydrofuran (THF, 5 mL) solution of 1,3-dimethoxybenzene (0.55 g, 4.0 mmol). After the reaction mixture was stirred at 0 °C for 2 h, N,N-dimethylformamide (DMF, 0.34 mL, 4.4 mmol) was added and stirring was continued at 0 °C for 2 h. The reaction mixture was then mixed with N,N-dimethylformamide (DMF, 0.34 mL, 4.4 mmol). Subsequently, ammonia solution (8 mL, 120 mmol) and dihydroammonium iodide (DIH, 0.91 g, 2.4 mmol) were added to the reaction system and the mixture was transferred to room temperature and stirred for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium sulfite solution (15 mL) and then extracted with ether (3 x 20 mL). The organic layers were combined, washed with brine and dried over anhydrous sodium sulfate. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=3:1) to afford pure 2,6-dimethoxybenzonitrile in 94% yield as a colorless solid.

References

[1] Tetrahedron, 2011, vol. 67, # 5, p. 958 - 964
[2] Synlett, 2010, # 10, p. 1562 - 1566

2,6-DIMETHOXYBENZONITRILE Preparation Products And Raw materials

Raw materials

Benzonitrile

Preparation Products

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2,6-DIMETHOXYBENZONITRILE Suppliers

Belgium 1 China 95 France 1 Germany 6 India 3 Japan 1 The Netherlands 1 United Kingdom 9 United States 21 Global 138
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View Lastest Price from 2,6-DIMETHOXYBENZONITRILE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2,6-DIMETHOXYBENZONITRILE 16932-49-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2025-03-11
Career Henan Chemical Co
Product
2,6-DIMETHOXYBENZONITRILE 16932-49-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-12

16932-49-3, 2,6-DIMETHOXYBENZONITRILERelated Search:

2,6-BIS(2,2,2-TRIFLUOROETHOXY)BENZONITRILE 3,5-DIMETHOXYBENZONITRILE / 3,5-DIMETHOXYLPHENYL CYANIDE,3,5-DIMETHOXYBENZONITRILE 2,4-DIMETHOXYBENZONITRILE 2,5-DIMETHOXYBENZONITRILE 2,6-DIBENZYLOXYBENZONITRILE 2,6-DIMETHOXYBENZONITRILE 2,4,6-Trimethoxybenzonitrile 2-BROMO-4,5-DIMETHOXY-BENZONITRILE 2-AMINO-4,5-DIMETHOXYBENZONITRILE TECHN. 95%,2-AMINO-4 5-DIMETHOXYBENZONITRILE 96%,2-AMINO-4,5-DIMETHOXYBENZONITRILE 2,3-DIMETHOXYBENZONITRILE 2-CHLORO-3,4-DIMETHOXYBENZONITRILE 2,3-DIMETHOXYBENZONITRILE,3,2-DIMETHOXYBENZONITRILE 2-FLUORO-6-DIMETHOXYBENZONITRILE 3-BROMO-4,5-DIMETHOXY-BENZONITRILE 2-ETHOXY-6-(2,2,2-TRIFLUOROETHOXY)BENZONITRILE 2-METHOXY-6-(2,2,2-TRIFLUOROETHOXY)BENZONITRILE 2-(BENZYLOXY)-6-METHOXYBENZONITRILE 2-[(2-CHLOROBENZYL)OXY]-6-METHOXYBENZONITRILE

  • AKOS 227-44
  • 2,6-Dimethoxybenzonitrile,97%
  • 2,6-Dimethoxybenzenecarbonitrile
  • 2,6-DIMETHOXYBENZONI
  • 2,6 methoxybenzonitrile
  • 2,6-dimethoxy-benzonitril
  • Benzonitrile, 2,6-dimethoxy-
  • 2,6-DIMETHOXYBENZONITRILE
  • 16932-49-3
  • Aromatic Nitriles