Musk ketone
- Product Name
- Musk ketone
- CAS No.
- 81-14-1
- Chemical Name
- Musk ketone
- Synonyms
- KETONE MOSCHUS;(-)-Licarin A;2-Acetyl-5-tert-butyl-4,6-dinitro-1,3-dimethylbenzene;1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl)-ethanon;MOSCHUS;Ketone musk;MUSK KETONE;Musk ketone 0;MOSCHUS KETON;MUSK KETONE 98+%
- CBNumber
- CB5458527
- Molecular Formula
- C14H18N2O5
- Formula Weight
- 294.3
- MOL File
- 81-14-1.mol
Musk ketone Property
- Melting point:
- 134-137 °C
- Boiling point:
- 436.08°C (rough estimate)
- Density
- 1.2051 (rough estimate)
- vapor pressure
- 0.001Pa at 25℃
- refractive index
- 1.5110 (estimate)
- Flash point:
- 2 °C
- storage temp.
- 2-8°C
- solubility
- DMSO : 250 mg/mL (849.47 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
- Odor
- at 10.00 % in benzyl benzoate. fatty musk soapy dry floral powdery
- Odor Type
- musk
- Water Solubility
- Insoluble (<0.1 g/100 mL at 20 ºC)
- BRN
- 2062638
- Stability:
- Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
- InChIKey
- WXCMHFPAUCOJIG-UHFFFAOYSA-N
- LogP
- 4.24 at 25℃
- CAS DataBase Reference
- 81-14-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,6-Dimethyl-3,5-dinitro-4-t-butylacetophenone(81-14-1)
- EPA Substance Registry System
- Musk ketone (81-14-1)
Safety
- Hazard Codes
- F,Xn,N
- Risk Statements
- 11-20/21/22-36-50/53-40
- Safety Statements
- 16-36/37-61-60-46
- RIDADR
- UN1648 3/PG 2
- WGK Germany
- 2
- RTECS
- KM5775841
- HS Code
- 2914790060
- Hazardous Substances Data
- 81-14-1(Hazardous Substances Data)
- Toxicity
- Both the acute oral LD50 in rats and the acute dermal LD50 in rabbits exceeded 10 g/kg (Fogleman, 1970).
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H312Harmful in contact with skin
H319Causes serious eye irritation
H332Harmful if inhaled
H351Suspected of causing cancer
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 46377
- Product name
- Musk ketone solution
- Purity
- 100 μg/mL in acetonitrile, analytical standard
- Packaging
- 2ml
- Price
- $75
- Updated
- 2022/05/15
- Product number
- S342963
- Product name
- 4'-TERT-BUTYL-2',6'-DIMETHYL-3',5'-DINITROACETOPHENONE
- Purity
- AldrichCPR
- Packaging
- 1g
- Price
- $179
- Updated
- 2024/03/01
- Product number
- W522902
- Product name
- Musk ketone
- Purity
- ≥98%
- Packaging
- sample
- Price
- $52
- Updated
- 2022/05/15
- Product number
- 6206AF
- Product name
- Musk ketone
- Packaging
- 100g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- FB55046
- Product name
- 4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone
- Packaging
- 250g
- Price
- $80
- Updated
- 2021/12/16
Musk ketone Chemical Properties,Usage,Production
Chemical Properties
White to light yellow crystal powde
Chemical Properties
It forms yellowish crystals with a sweet, very
persistent, slightly animal musk odor.Musk ketone is prepared by Friedel–Crafts
acetylation of 1,3-dimethyl-5-tert-butylbenzene and nitration of the resulting 2,6-
dimethyl-4-tert-butylacetophenone with nitric acid.
Musk ketone is widely used as a fixative in blossom and fantasy compositions.
Occurrence
Has apparently not been reported to occur in nature.
Uses
Musk ketone is used as fragrance and fixative in after-shave lotions, perfumes, ete.
Definition
ChEBI: 4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone is an aromatic ketone.
Preparation
Nitration of the corresponding benzene derivative (Bedoukian, 1967).
General Description
Light yellow crystalline solid. Insoluble in water.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
Fire Hazard
Flash point data is not available for Musk ketone, however, Musk ketone is probably combustible.
Flammability and Explosibility
Not classified
Purification Methods
Purify the ketone by recrystallisation from MeOH. It has a strong odour of musk and is used in perfumery. [Fuson et al. J Org Chem 12 587 1947, Beilstein 7 IV 808.]
Musk ketone Preparation Products And Raw materials
Raw materials
Preparation Products
Musk ketone Suppliers
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- India
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View Lastest Price from Musk ketone manufacturers
- Product
- Musk ketone 81-14-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-22
- Product
- Musk ketone 81-14-1
- Price
- US $80.00-66.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 10 tons
- Release date
- 2024-06-19
- Product
- Musk ketone 81-14-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2024-06-24