5,5-DIETHYLBARBITURIC ACID SODIUM SALT Property

Melting point:

190℃

Density 

1.418[at 20℃]

vapor pressure 

0.004Pa at 90℃

solubility 

H2O: soluble50mg/mL, clear, colorless

form 

Solid

color 

Bitter crystals or powder

Water Solubility 

181.6g/L at 20℃

Merck 

13,965

BRN 

3921202

InChIKey

RGHFKWPGWBFQLN-UHFFFAOYSA-M

CAS DataBase Reference

144-02-5(CAS DataBase Reference)

Safety

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

RIDADR 

3288

WGK Germany 

3

RTECS 

CQ3850000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29335300

Toxicity

TDLo orl-rat: 121 g/kg/72W-C:NEO CRNGDP11,2149,90

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H371May cause damage to organs

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

5,5-DIETHYLBARBITURIC ACID SODIUM SALT Chemical Properties,Usage,Production

Chemical Properties

Bitter crystals or powder.

Uses

Biological buffer.

Definition

The soluble monosodium salt of barbital. It is a long-acting bar- biturate that depresses most metabolic processes at high doses.

Hazard

Poison; causes marked depression, pro- longed coma, and death; teratogen; questionable carcinogen; tumorigen; neoplastigen; mutagen.

Flammability and Explosibility

Not classified

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Large doses cause marked depression (sometimes preceded by excitation), prolonged coma, and death. Experimental teratogenic and reproductive effects. Allergic skin reactions may occur on contact. Implicated in development of aplastic anemia. Questionable carcinogin with experimental tumorigenic and neoplastigenic data. A truly habit-forming drug. Other experimental reproductive effects. Mutation data reported. Combustible. When heated to decomposition it emits toxic fumes of NO, and NazO. See also BARBITURATES

Purification Methods

Crystallise it from water (3mL/g) by adding an equal volume of EtOH and cooling to 5o. Dry it under vacuum over P2O5. [Beilstein 24 III/IV 1904.]