OLVANIL
- Product Name
- OLVANIL
- CAS No.
- 58493-49-5
- Chemical Name
- OLVANIL
- Synonyms
- Ovanil;OLVANIL;NE-19550;N-VANILLYLOLEAMIDE;N-VANILLYLOLEOYLAMIDE;N-Vannilyloleoylamide;(n-vanillyl)-9-oleamide;N-VANILLYL-9-OCTADECENAMIDE;Olvanil (cis- and trans- mixture);N-(4-Hydroxy-3-methoxybenzyl)oleamide
- CBNumber
- CB5461006
- Molecular Formula
- C26H43NO3
- Formula Weight
- 417.62
- MOL File
- 58493-49-5.mol
OLVANIL Property
- Melting point:
- 36 °C
- Boiling point:
- 596.1±50.0 °C(Predicted)
- Density
- 0.982±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- H2O: <0.2mg/mL
- form
- powder
- pka
- 9.76±0.20(Predicted)
- color
- white to off-white
Safety
- WGK Germany
- 3
- RTECS
- RG2242130
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- O0257
- Product name
- Olvanil
- Purity
- powder
- Packaging
- 10mg
- Price
- $191
- Updated
- 2024/03/01
- Product number
- J67092
- Product name
- Olvanil, 98%
- Packaging
- 25mg
- Price
- $294
- Updated
- 2021/12/16
- Product number
- J67092
- Product name
- Olvanil, 98%
- Packaging
- 5mg
- Price
- $73.3
- Updated
- 2021/12/16
- Product number
- 90262
- Product name
- Olvanil
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $53
- Updated
- 2024/03/01
- Product number
- 90262
- Product name
- Olvanil
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $96
- Updated
- 2024/03/01
OLVANIL Chemical Properties,Usage,Production
Description
Olvanil is a structural analog of capsaicin, which is the noxious active component of hot peppers of the Capsicum genus. It is the amide of vanillylamine and oleic acid. Olvanil acts as an agonist at the vanilloid receptor, VR1, inducing desensitization analgesia in rat and mouse models of pain. Olvanil has complex interactions with the cannabinoid system, in that it potentiates the agonist activity of endogenous cannabinoids by inhibiting the reuptake of arachidonyl ethanolamide (AEA). Olvanil is a more potent reuptake inhibitor than AM404, which is commonly used for this purpose (50% inhibition of reuptake at 10 μM versus 12% for AM404 at the same dose). Olvanil is also a CB1 agonist, but does not bind to CB2 receptors or inhibit fatty acid amide hydrolase. The overall activity of olvanil in most models is that of an analgesic, but it is unclear how these effects are mediated by VR1, the CB1 receptor, or other components of the endogenous pain sensation system.
Uses
Analgesic.
Uses
Olvanil is a TRPV1 agonist more potent than capsaicin.
Definition
ChEBI: N-Vanillyloleamide is a member of methoxybenzenes and a member of phenols.
Biological Activity
Potent vanilloid receptor agonist (pEC 50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC 50 = 9 μ M) and may bind to CB 1 cannabinoid receptors. Antinociceptive following systemic administration. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .
storage
Desiccate at -20°C
OLVANIL Preparation Products And Raw materials
Raw materials
Preparation Products
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