ChemicalBook > CAS DataBase List > Schisantherin A

Schisantherin A

Product Name: Schisantherin A
CAS No.: 58546-56-8
Chemical Name: Schisantherin A
Synonyms: Gomisin C(P);Schisantherin A;Schisantherin A-RM;SCHISANTHERINGOMISIN;Gomisin C(Schisantherin A);Schisantherin A (Gomisin-C;SCHISANTHERIN A 98.0% BY HPLC;Gomisin, 98%, from Schisandra chinensis;(5S,6S,7S,13aS)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f];Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxole-5,6-diol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, 5-benzoate, (5S,6S,7S,13aS)-
CBNumber: CB5462083
Molecular Formula: C30H32O9
Formula Weight: 536.57
MOL File: 58546-56-8.mol

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Schisantherin A Property

Melting point:: 110～112℃
Boiling point:: 675.6±55.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 13.70±0.60(Predicted)
color: White to Off-White
Water Solubility: insoluble in water

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Safety

Safety Statements: 24/25
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: G0538
Product name: Gomisin C
Packaging: 25MG
Price: $71
Updated: 2025/07/31

TCI Chemical

Product number: G0538
Product name: Gomisin C
Packaging: 100MG
Price: $214
Updated: 2025/07/31

Cayman Chemical

Product number: 18643
Product name: Gomisin C
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18643
Product name: Gomisin C
Purity: ≥98%
Packaging: 10mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 18643
Product name: Gomisin C
Purity: ≥98%
Packaging: 25mg
Price: $116
Updated: 2024/03/01

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Schisantherin A Chemical Properties,Usage,Production

Chemical Properties

Rectangular crystals (ethanol), mp 122°C-124°C, [α]D23 -175° (c=0.12, chloroform). Soluble in benzene, chloroform, acetone, soluble in methanol, ethanol, insoluble in petroleum ether, insoluble in water. Seven biphenyl cyclooctenoid lignans with transaminase-lowering activity were isolated from the ethanol extract of Schisandra chinensis kernels, including deoxyschisandrin, schisandrin, schisandrin, schisandrin, schisandrin, schisandrinol ethyl, schisandrin ester A and schisandrin ester ethyl. All seven components have the effect of lowering SGPT, promoting hepatic gluconeogenesis and prolonging pentobarbital sleep time. Schisandra chinensis ester B had the strongest SGPT-lowering effect, Schisandra chinensis alcohol B had the most significant effect in promoting hepatic gluconeogenesis, and Schisandra chinensis prolonged pentobarbital sleep time most prominently.

Uses

Schisantherin A?is a ligand from Schisandra chinensis. It is capable of?suppressing interleukin-1β-induced inflammation in human chondrocytes by inhibiting NF-κB and MAPKs activation.

Definition

ChEBI: Schisantherin A is a tannin.

in vivo

Schisantherin A, a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been reported to possess varied beneficial pharmacological effects. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. Pretreatment with Schisantherin A markedly ameliorates LPS-induced histopathologic changes and decreases the levels of TNF-α, IL-6 and IL-1β in the BALF. In addition, the phosphorylation of NF-κB p65, IκB-α, JNK, ERK and p38 induced by LPS are suppressed by Schisantherin A. The lung wet/dry weight ratio is evaluated at 7 h after the intranasal instillation of LPS. The results show that there are no differences between control group and Schisantherin A (40 mg/kg) group (p>0.05). LPS causes a significant increase in lung wet/dry weight ratio (p<0.01) compared with the control group. Schisantherin A dose-dependently decreases the lung wet/dry weight ratio (p<0.05) compared to those in the LPS group^[1].

target

ROS | NO | NOS | MAPK | PI3K | GSK-3 | IL Receptor | PGE | TNF-α | COX | ERK | p38MAPK | JNK | NF-kB | Beta Amyloid | Akt

IC 50

p65

Schisantherin A Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Schisantherin A manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Schisantherin A 58546-56-8
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-23

Shanghai Standard Technology Co., Ltd.

Product: Schisantherin A 58546-56-8
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-10-23

Career Henan Chemical Co

Product: Schisantherin A 58546-56-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-05-25

58546-56-8, Schisantherin ARelated Search:

Schisandrin A Meclofenoxate hydrochloride 2-(Dimethylamino)ethyl (4-chlorphenoxy)acetate Gabexate mesylate Gomisin A SCHIZANDRIN B SCHISANTHERIN C 98+% HPLC schisanhenol WUWEIZISU C Schisandrin Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-, stereoisomer SCHISANTHERIN B,SCHISANTHERIN B 98.0% BY HPLC Schisantherin E 4-HYDROXY-4'-METHOXYBIPHENYL 3-(3,4-DIMETHOXYPHENYL)-1-PROPANOL Masoprocol 2,2'-Biphenol Gomisin B(Schisantherin B)

SCHISANTHERIN A 98.0% BY HPLC

Schisantherin A (Gomisin-C

Gomisin C(Schisantherin A)

Schisantherin A

SCHISANTHERINGOMISIN

Gomisin, 98%, from Schisandra chinensis

Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxole-5,6-diol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, 5-benzoate, (5S,6S,7S,13aS)-

(5S,6S,7S,13aS)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f]

(5S,6S,7S)-6-Hydroxy-1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-5-yl benzoate

Gomisin C(P)

Schisantherin A-RM

58546-56-8

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Heterocycles