Schisantherin A
- Product Name
- Schisantherin A
- CAS No.
- 58546-56-8
- Chemical Name
- Schisantherin A
- Synonyms
- Gomisin C(P);Schisantherin A;Schisantherin A-RM;SCHISANTHERINGOMISIN;Gomisin C(Schisantherin A);Schisantherin A (Gomisin-C;SCHISANTHERIN A 98.0% BY HPLC;Gomisin, 98%, from Schisandra chinensis;(5S,6S,7S,13aS)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f];Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxole-5,6-diol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, 5-benzoate, (5S,6S,7S,13aS)-
- CBNumber
- CB5462083
- Molecular Formula
- C30H32O9
- Formula Weight
- 536.57
- MOL File
- 58546-56-8.mol
Schisantherin A Property
- Melting point:
- 110～112℃
- Boiling point:
- 675.6±55.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 13.70±0.60(Predicted)
- color
- White to Off-White
- Water Solubility
- insoluble in water
Safety
- Safety Statements
- 24/25
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- G0538
- Product name
- Gomisin C
- Packaging
- 25MG
- Price
- $71
- Updated
- 2025/07/31
- Product number
- G0538
- Product name
- Gomisin C
- Packaging
- 100MG
- Price
- $214
- Updated
- 2025/07/31
- Product number
- 18643
- Product name
- Gomisin C
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18643
- Product name
- Gomisin C
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 18643
- Product name
- Gomisin C
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $116
- Updated
- 2024/03/01
Schisantherin A Chemical Properties,Usage,Production
Chemical Properties
Rectangular crystals (ethanol), mp 122°C-124°C, [α]D23 -175° (c=0.12, chloroform). Soluble in benzene, chloroform, acetone, soluble in methanol, ethanol, insoluble in petroleum ether, insoluble in water. Seven biphenyl cyclooctenoid lignans with transaminase-lowering activity were isolated from the ethanol extract of Schisandra chinensis kernels, including deoxyschisandrin, schisandrin, schisandrin, schisandrin, schisandrin, schisandrinol ethyl, schisandrin ester A and schisandrin ester ethyl. All seven components have the effect of lowering SGPT, promoting hepatic gluconeogenesis and prolonging pentobarbital sleep time. Schisandra chinensis ester B had the strongest SGPT-lowering effect, Schisandra chinensis alcohol B had the most significant effect in promoting hepatic gluconeogenesis, and Schisandra chinensis prolonged pentobarbital sleep time most prominently.
Uses
Schisantherin A?is a ligand from Schisandra chinensis. It is capable of?suppressing interleukin-1β-induced inflammation in human chondrocytes by inhibiting NF-κB and MAPKs activation.
Definition
ChEBI: Schisantherin A is a tannin.
in vivo
Schisantherin A, a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been reported to possess varied beneficial pharmacological effects. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. Pretreatment with Schisantherin A markedly ameliorates LPS-induced histopathologic changes and decreases the levels of TNF-α, IL-6 and IL-1β in the BALF. In addition, the phosphorylation of NF-κB p65, IκB-α, JNK, ERK and p38 induced by LPS are suppressed by Schisantherin A. The lung wet/dry weight ratio is evaluated at 7 h after the intranasal instillation of LPS. The results show that there are no differences between control group and Schisantherin A (40 mg/kg) group (p>0.05). LPS causes a significant increase in lung wet/dry weight ratio (p<0.01) compared with the control group. Schisantherin A dose-dependently decreases the lung wet/dry weight ratio (p<0.05) compared to those in the LPS group[1].
target
ROS | NO | NOS | MAPK | PI3K | GSK-3 | IL Receptor | PGE | TNF-α | COX | ERK | p38MAPK | JNK | NF-kB | Beta Amyloid | Akt
IC 50
p65
Schisantherin A Preparation Products And Raw materials
Raw materials
Preparation Products
Schisantherin A Suppliers
- Tel
- --
- Fax
- --
- Country
- Germany
- ProdList
- 1136
- Advantage
- 62
View Lastest Price from Schisantherin A manufacturers
- Product
- Schisantherin A 58546-56-8
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-10-23
- Product
- Schisantherin A 58546-56-8
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- Analytical Standard
- Supply Ability
- 10 g
- Release date
- 2019-10-23
- Product
- Schisantherin A 58546-56-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-05-25