Megestrol

Product Name: Megestrol
CAS No.: 3562-63-8
Chemical Name: Megestrol
Synonyms: C07120;Megestro;MEGESTROL;Megestrol USP/EP/BP;Megestrol in Methanol;megestrol solution,100ppm;Megestrol acetate EP Impurity B;Megestrol 100 μg/ml Acetonitrile;Metesterone acetate EP impurity B;4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE
CBNumber: CB5465978
Molecular Formula: C22H30O3
Formula Weight: 342.47
MOL File: 3562-63-8.mol

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Megestrol Property

Melting point:: 207-208 °C(Solv: ethyl ether (60-29-7); acetone (67-64-1))
Boiling point:: 500.4±50.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 13.00±0.70(Predicted)
color: White to Off-White
CAS DataBase Reference: 3562-63-8(CAS DataBase Reference)

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Safety

Hazardous Substances Data: 3562-63-8(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M208040
Product name: Megestrol
Packaging: 50mg
Price: $145
Updated: 2021/12/16

Usbiological

Product number: M2860-55B
Product name: Megestrol
Packaging: 500ul
Price: $306
Updated: 2021/12/16

TRC

Product number: M208040
Product name: Megestrol
Packaging: 500mg
Price: $1165
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006501
Product name: MEGESTROL
Purity: 95.00%
Packaging: 500MG
Price: $1686.3
Updated: 2021/12/16

ChemScene

Product number: CS-0013903
Product name: Megestrol
Purity: 99.69%
Packaging: 100mg
Price: $200
Updated: 2021/12/16

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Megestrol Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Megestrol is an orally active progestogen. Megestrol is used in combinations as oral contraceptive and as antineoplastic agent.

Indications

As a representitive of the compounds of the class of progestins, this drug is used for various forms of cancer, in particular cancer of the breast, kidneys, and others.

Definition

ChEBI: A 3-oxo Delta4-steroid that is pregna-4,6-diene-3,20-dione substituted by a hydroxy group at position 17.

brand name

Megace (Bristol-Myers Squibb); Megace (Par);Citestrol;Co-ervonum;Combiquens;Femagest;Kombiquens;Megecat;Megeron;Megestat;Menoquens;Neo-delpregnin;Niaestine;Niagestine;Novaquin;Novokvens;Novolina;Novoquens;Oracolnal;Ovaban;Ovarid;Pallace;Serial 28;Volidan;Volplan.

World Health Organization (WHO)

Megestrol acetate, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, megestrol acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and megestrol remains available in some countries for contraceptive purposes. In other countries its use is restricted to anticancer treatment. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)

Synthesis

Megestrol, 17|á-hydroxy-6|á-methylpregna-4,6-dien-3,20-dione acetate (28.3.9), is a product of dehydrogenation medroxyprogesterone (28.3.7) with chloranil (tetrachloro-p-benzoquinone) in the presence of p-toluenesulfonic acid, which results in the formation of an additional double bond at position C6¨CC7, and subsequent acetylation of the product (28.3.8) leads to the desired megestrol (28.3.9) by acetic anhydride in the presence of p-toluenesulfonic acid.

Megestrol Preparation Products And Raw materials

Raw materials

Preparation Products

17-Hydroxy-6-methylpregn-4-ene-3,20-dione 17-acetate

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Megestrol Suppliers

Canada 2 China 129 Europe 2 India 5 South Korea 1 United Kingdom 1 United States 21 Global 161

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Standardpharm Co. Ltd.

Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Country: United States
ProdList: 14332
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10404
Advantage: 58

TargetMol Chemicals Inc.

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Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

United States Biological

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Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

EJY Tech, Inc.

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ProdList: 448
Advantage: 30

AlliChem, LLC

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Country: United States
ProdList: 6516
Advantage: 60

Waterstone Technology, LLC

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Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

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Country: United States
ProdList: 6398
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Olinax Inc.

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Country: United States
ProdList: 404
Advantage: 50

HONEST JOY HOLDINGS LIMITED

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Country: United States
ProdList: 6675
Advantage: 54

3B Scientific Corporation

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Country: United States
ProdList: 6718
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APAC Pharmaceutical, LLC

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ProdList: 6322
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AK Scientific, Inc.

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ProdList: 6347
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ChemPacific Corporation

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Country: United States
ProdList: 6891
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Steraloids Inc.

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Country: United States
ProdList: 2357
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View Lastest Price from Megestrol manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: Megestrol 3562-63-8
Price: US $10.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-21

Shaanxi Dideu Medichem Co. Ltd

Product: Megestrol 3562-63-8
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-19

Shaanxi Dideu Medichem Co. Ltd

Product: Megestrol 3562-63-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

3562-63-8, MegestrolRelated Search:

CHLOROPHOSPHONAZO III MEGESTROL ACETATE,MEGESTROL 17-ACETATE,MEGESTROL ACETATE-D3,MEGESTROL 17-ACETATE VETRANAL, 100 MG,Megestrol Acetate, Micronized,Megestrol Acetate, Milled Powder Premarin 17-Hydroxy-6-methylpregn-4-ene-3,20-dione 17-acetate Megestrol acetate EP Impurity E (2β)-Methyl Megestrol Acetate 4,7-Dihydro Megestrol Acetate AQMUMBCTNJGBGC-FGPIKTEISA-N Hydroxyprogesterone acetate Medroxyprogesterone Acetate 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate Melengestrol acetate Progesterone melengestrol Megestrol Acetate 2-Methyl-1-megestrol Acetate (Megestrol Acetate Impurity) MEGESTROL ACETATE - REFERENCE SPECTRUM Megestrol

17-hydroxy-6-methylpregna-4,6-diene-3,20-dione

20-dione,17-hydroxy-6-methyl-pregna-6-diene-3

4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE

17-ALPHA-HYDROXY-6-METHYL-4,6-PREGNADIENE-3,20-DIONE

MEGESTROL

17-alpha-hydroxy-6-methylpregna-4,6-diene-3,20-dione

Megestrol (base and/or unspecified salts)

C07120

megestrol solution,100ppm

(8R,9S,10R,13S,14S,17R)-17-Acetyl-17-hydroxy-6,10,13-trimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

Megestrol acetate EP Impurity B

Megestrol Acetate Impurity 2(Megestrol Acetate EP Impurity B)(Megestrol)

Megestro

Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-

Megestrol Acetate Impurity 2（Megestrol Acetate EP Impurity B）

Metesterone acetate EP impurity B

Megestrol USP/EP/BP

Megestrol in Methanol

Megestrol 100 μg/ml Acetonitrile

3562-63-8

Hormone Drugs

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids

3562-63-8