ChemicalBook > CAS DataBase List > Soticlestat

Soticlestat

Product Name: Soticlestat
CAS No.: 1429505-03-2
Chemical Name: Soticlestat
Synonyms: OV935;TAK-935;Soticlestat;Soticlestat??(TAK-935;Soticlestat/TAK-935/OV935;Soticlestat, 10 mM in DMSO;2,4’-Bipyridin]-3-yl(4-benzyl-4-hydroxy-1-piperidyl)methanone;2,4'-Bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone;[2,4'-Bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone;Methanone, [2,4'-bipyridin]-3-yl[4-hydroxy-4-(phenylmethyl)-1-piperidinyl]-
CBNumber: CB54668528
Molecular Formula: C23H23N3O2
Formula Weight: 373.45
MOL File: 1429505-03-2.mol

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Soticlestat Property

solubility: DMSO: soluble
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0078356
Product name: Soticlestat
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0078356
Product name: Soticlestat
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0078356
Product name: Soticlestat
Packaging: 25mg
Price: $650
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573114
Product name: Soticlestat
Purity: >98%
Packaging: 10mg
Price: $690.2
Updated: 2021/12/16

ChemScene

Product number: CS-0078356
Product name: Soticlestat
Packaging: 50mg
Price: $950
Updated: 2021/12/16

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Soticlestat Chemical Properties,Usage,Production

Uses

Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research[1][2].

in vivo

Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus^[1].

Animal Model:	Amyloid precursor protein and presenilin 1 (APP/PS1-Tg) mice (7-week-old)^[1]
Dosage:	10 mg/kg
Administration:	Oral administration; once daily; for 1 days, 3 days and 7 days
Result:	Lowered brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%.

References

[1] Toshiya Nishi, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081. DOI:10.1038/s41598-020-74036-6
[2] Krista Eschbach, et al. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388. DOI:10.1080/17512433.2019.1605904

Soticlestat Preparation Products And Raw materials

Raw materials

Preparation Products

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Soticlestat Suppliers

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1429505-03-2, SoticlestatRelated Search:

Mobocertinib Tak 799 TAK-960 TAK-632 TAK875 TAK-733 Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]- 6-[(7S)-7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthalenecarboxamide

Soticlestat

TAK-935

Methanone, [2,4'-bipyridin]-3-yl[4-hydroxy-4-(phenylmethyl)-1-piperidinyl]-

OV935

Inhibitor,CYP46A1,inhibit,cholesterol,24-hydroxylase,OV 935,Soticlestat,NMDA,antiepileptic,TAK935,CYPs,epilepsy,TAK 935,Cytochrome P450,OV-935

2,4’-Bipyridin]-3-yl(4-benzyl-4-hydroxy-1-piperidyl)methanone

Soticlestat/TAK-935/OV935

2,4'-Bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone

Soticlestat??(TAK-935

Soticlestat, 10 mM in DMSO

[2,4'-Bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone

1429505-03-2