ChemicalBook > CAS DataBase List > Tak 799
Tak 799
- Product Name
- Tak 799
- CAS No.
- 229005-80-5
- Chemical Name
- Tak 799
- Synonyms
- CS-2889;Tak 799;Takeda 779;TAK-779(Cl);TAK 799 ;TAK 779;TAK-779 >=98% (HPLC);TAK-779;TAK 779;TAK779;TAK779;TAK 799;TAKEDA 779;TAK-779 Chemical Structure;N,N-Dimethyl-N-(4-(2-(p-tolyl)-6,7-dihydro-5H-benzo[7]annulene-8-carboxamido)benzyl)tetrahydro-2H-pyran-4-aminium chloride
- CBNumber
- CB72497117
- Molecular Formula
- C33H39N2O2.Cl
- Formula Weight
- 531.136
- MOL File
- 229005-80-5.mol
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Tak 799 Property
- storage temp.
- 2-8°C
- solubility
- H2O: soluble3mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0911
- Product name
- TAK-779
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $195
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0911
- Product name
- TAK-779
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $299.2
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 26744
- Product name
- TAK-779
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 26744
- Product name
- TAK-779
- Packaging
- 25mg
- Price
- $344
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 26744
- Product name
- TAK-779
- Packaging
- 5mg
- Price
- $129
- Updated
- 2024/03/01
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Tak 799 Chemical Properties,Usage,Production
Uses
TAK-779 has been used to inhibit CC chemokine ligand 5 (CCL5)– C-C chemokine receptor type 5 (CCR5) interaction in vitro in natural killer (NK) cytotoxicity assay. It has also been used as a blocker of CCR5 to study its effects and to evaluate the opening of the Panx-1 channels on peripheral blood mononuclear cells (PBMCs) isolated from human immunodeficiency virus (HIV)-infected individuals.
Biochem/physiol Actions
TAK-779 is a potent, dual antagonist at chemokine receptors C-C chemokine receptor type 2 (CCR2) and C-C chemokine receptor type 5 (CCR5) with IC50 = 1.4 nM at CCR5 and 2.3 nM at CCR2. Antagonists of both CCR2 and CCR5 such as TAK-779 have been investigated for treatment of viruses, rheumatoid arthritis, multiple sclerosis, and cancer. CCR5 is particularly targeted for anti-HIV therapy, since HIV entry into cells requires chemokine coreceptors CCR5 and C-X-C motif chemokine receptor 4 (CXCR4).
storage
Store at -20°C
Tak 799 Preparation Products And Raw materials
Raw materials
Preparation Products
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Tak 799 Suppliers
- Tel
- 0512-0512-13601744364 13601744364
- chemsharker@126.com
- Country
- China
- ProdList
- 918
- Advantage
- 58
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- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
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- China
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- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
- 58
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3466
- Advantage
- 58
- Tel
- 18939837085
- Fax
- 2880152141(QQ)
- youchemicals@gmail.com
- Country
- China
- ProdList
- 1830
- Advantage
- 55
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
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- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
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- Advantage
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- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
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- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
229005-80-5, Tak 799Related Search:
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6-[(7S)-7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthalenecarboxamide