Tak 799

ChemicalBook > CAS DataBase List > Tak 799

Product Name: Tak 799
CAS No.: 229005-80-5
Chemical Name: Tak 799
Synonyms: CS-2889;Tak 799;Takeda 779;TAK-779(Cl);TAK 799 ;TAK 779;TAK-779 >=98% (HPLC);TAK-779;TAK 779;TAK779;TAK779;TAK 799;TAKEDA 779;TAK-779 Chemical Structure;N,N-Dimethyl-N-(4-(2-(p-tolyl)-6,7-dihydro-5H-benzo[7]annulene-8-carboxamido)benzyl)tetrahydro-2H-pyran-4-aminium chloride
CBNumber: CB72497117
Molecular Formula: C33H39N2O2.Cl
Formula Weight: 531.136
MOL File: 229005-80-5.mol

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Tak 799 Property

storage temp.: 2-8°C
solubility: H2O: soluble3mg/mL, clear (warmed)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0911
Product name: TAK-779
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $195
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0911
Product name: TAK-779
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $299.2
Updated: 2024/03/01

Cayman Chemical

Product number: 26744
Product name: TAK-779
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 26744
Product name: TAK-779
Packaging: 25mg
Price: $344
Updated: 2024/03/01

Cayman Chemical

Product number: 26744
Product name: TAK-779
Packaging: 5mg
Price: $129
Updated: 2024/03/01

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Tak 799 Chemical Properties,Usage,Production

Uses

TAK-779 has been used to inhibit CC chemokine ligand 5 (CCL5)– C-C chemokine receptor type 5 (CCR5) interaction in vitro in natural killer (NK) cytotoxicity assay. It has also been used as a blocker of CCR5 to study its effects and to evaluate the opening of the Panx-1 channels on peripheral blood mononuclear cells (PBMCs) isolated from human immunodeficiency virus (HIV)-infected individuals.

Biochem/physiol Actions

TAK-779 is a potent, dual antagonist at chemokine receptors C-C chemokine receptor type 2 (CCR2) and C-C chemokine receptor type 5 (CCR5) with IC50 = 1.4 nM at CCR5 and 2.3 nM at CCR2. Antagonists of both CCR2 and CCR5 such as TAK-779 have been investigated for treatment of viruses, rheumatoid arthritis, multiple sclerosis, and cancer. CCR5 is particularly targeted for anti-HIV therapy, since HIV entry into cells requires chemokine coreceptors CCR5 and C-X-C motif chemokine receptor 4 (CXCR4).

storage

Store at -20°C

Tak 799 Preparation Products And Raw materials

Raw materials

Preparation Products

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Tak 799 Suppliers

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229005-80-5, Tak 799Related Search:

Mobocertinib TAK-960 Soticlestat TAK-632 TAK875 TAK-733 Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]- 6-[(7S)-7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthalenecarboxamide

2H-Oyran-4-aminium, N-((4-(((6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl)carbonyl)amino)phenyl)methyl)tetrahydro-N,N-dimethyl-

2H-Pyran-4-aminium, N,N-dimethyl-N-(4-(((2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-yl)carbonyl)amino)benzyl)tetrahydro-, chloride

N,N-Dimethyl-N-(4-(((2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-yl)carbonyl)amino)benzyl)tetrahydro-2H-pyran-4-aminium chloride

Tak 799

Takeda 779

TAK 799 ;TAK 779

TAK779;TAK 799;TAKEDA 779

N,N-Dimethyl-N-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5H-benzohepten-8-yl]carbonyl]amino]benzyl]tetrahydro-2H-pyran-4-aminium chloride

TAK-779 Chemical Structure

TAK-779(Cl)

CS-2889

TAK-779;TAK 779;TAK779

TAK-779 >=98% (HPLC)

TAK-779,TAK 779,CCR,HIV,Human immunodeficiency virus,Takeda779,Takeda-779,TAK779,CXCR,inhibit,CXC chemokine receptors,CC chemokine receptor,Inhibitor

N,N-Dimethyl-N-(4-(2-(p-tolyl)-6,7-dihydro-5H-benzo[7]annulene-8-carboxamido)benzyl)tetrahydro-2H-pyran-4-aminium chloride

229005-80-5