ChemicalBook > CAS DataBase List > Tak 799

Tak 799

Product Name: Tak 799
CAS No.: 229005-80-5
Chemical Name: Tak 799
Synonyms: CS-2889;Tak 799;Takeda 779;TAK-779(Cl);TAK-779 (TAK779;TAK 799 ;TAK 779;TAK-779 >=98% (HPLC);TAK-779;TAK 779;TAK779;TAK-779, 10 mM in DMSO;TAK779;TAK 799;TAKEDA 779
CBNumber: CB72497117
Molecular Formula: C33H39N2O2.Cl
Formula Weight: 531.136
MOL File: 229005-80-5.mol

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Tak 799 Property

storage temp.: 2-8°C
solubility: H2O: soluble3mg/mL, clear (warmed)
form: powder
color: white to beige
Water Solubility: H2O: 3mg/mL, clear (warmed)
InChIKey: VDALIBWXVQVFGZ-UHFFFAOYSA-N
SMILES: C(=O)(NC1C=CC(=CC=1)C[N+](C)(C)C1CCOCC1)C1CCCC2C=CC(C3C=CC(C)=CC=3)=CC=2C=1.[Cl-]

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0911
Product name: TAK-779
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $200
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0911
Product name: TAK-779
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $384.5
Updated: 2025/07/31

Cayman Chemical

Product number: 26744
Product name: TAK-779
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 26744
Product name: TAK-779
Packaging: 25mg
Price: $344
Updated: 2024/03/01

Cayman Chemical

Product number: 26744
Product name: TAK-779
Packaging: 5mg
Price: $129
Updated: 2024/03/01

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Tak 799 Chemical Properties,Usage,Production

Uses

TAK-779 has been used to inhibit CC chemokine ligand 5 (CCL5)– C-C chemokine receptor type 5 (CCR5) interaction in vitro in natural killer (NK) cytotoxicity assay. It has also been used as a blocker of CCR5 to study its effects and to evaluate the opening of the Panx-1 channels on peripheral blood mononuclear cells (PBMCs) isolated from human immunodeficiency virus (HIV)-infected individuals.

Biochem/physiol Actions

TAK-779 is a potent, dual antagonist at chemokine receptors C-C chemokine receptor type 2 (CCR2) and C-C chemokine receptor type 5 (CCR5) with IC50 = 1.4 nM at CCR5 and 2.3 nM at CCR2. Antagonists of both CCR2 and CCR5 such as TAK-779 have been investigated for treatment of viruses, rheumatoid arthritis, multiple sclerosis, and cancer. CCR5 is particularly targeted for anti-HIV therapy, since HIV entry into cells requires chemokine coreceptors CCR5 and C-X-C motif chemokine receptor 4 (CXCR4).

in vivo

TAK-779 (10 mg/kg per day, s.c.) significantly prolongs the allograft survival of the rat intestinal transplantation model. TAK-779 also decreases the number of CD4⁺ as well as CD8⁺ T cells in spleen, blood and recipient mesenteric lymph nodes (MLN)^[2]. TAK-779 (150 μg per mouse, s.c.) supppresses the development of experimental autoimmune encephalomyelitis (EAE) in myelin oligodendrocyte glycoprotein (MOG)-immunized C57BL/6 mice. TAK-779 decreases the infiltration of CXCR3 and CCR5 bearing leukocytes into the spinal cord. TAK-779 does not alter myelin oligodendrocyte glycoprotein (MOG)-specific immune responses or affect the potential of MOG-specific T cells to transfer experimental autoimmune encephalomyelitis (EAE)^[3].

IC 50

MIP-1α-CCR5: 1 nM (IC₅₀, in CHO/CCR5 cells); MIP-1β-CCR5: 1 nM (IC₅₀, in CHO/CCR5 cells); RANTES-CCR5: 1.4 nM (IC₅₀, in CHO/CCR5 cells); MCP-1-CCR2b: 27 nM (IC₅₀, in CHO/CCR5 cells); R5 HIV-1 (Ba-L): 1.2 nM (EC₅₀, in MAGI-CCR5 cells); R5 HIV-1 (KK): 1.6 nM (EC₅₀, in PBMCs); R5 HIV-1 (HHA): 3.2 nM (EC₅₀, in PBMCs); R5 HIV-1 (CTV): 3.5 nM (EC₅₀, in PBMCs); R5 HIV-1 (Ba-L): 3.7 nM (EC₅₀, in PBMCs); R5 HIV-1 (Ba-L): 5.7 nM (EC90, in MAGI-CCR5 cells); R5 HIV-1 (HHA): 7.5 nM (EC90, in PBMCs); R5 HIV-1 (Ba-L): 12.8 nM (EC90, in PBMCs); R5 HIV-1 (KK): 20.8 nM (EC90, in PBMCs); R5 HIV-1 (CTV): 27 nM (EC90, in PBMCs); mCXCR3: 369 nM (IC₅₀, in PBMCs)

storage

Store at -20°C

Tak 799 Preparation Products And Raw materials

Raw materials

Preparation Products

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Tak 799 Suppliers

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229005-80-5, Tak 799Related Search:

Mobocertinib TAK-960 Soticlestat TAK-632 TAK875 TAK-733 Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]- 6-[(7S)-7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthalenecarboxamide

2H-Oyran-4-aminium, N-((4-(((6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl)carbonyl)amino)phenyl)methyl)tetrahydro-N,N-dimethyl-

2H-Pyran-4-aminium, N,N-dimethyl-N-(4-(((2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-yl)carbonyl)amino)benzyl)tetrahydro-, chloride

N,N-Dimethyl-N-(4-(((2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-yl)carbonyl)amino)benzyl)tetrahydro-2H-pyran-4-aminium chloride

Tak 799

Takeda 779

TAK 799 ;TAK 779

TAK779;TAK 799;TAKEDA 779

N,N-Dimethyl-N-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5H-benzohepten-8-yl]carbonyl]amino]benzyl]tetrahydro-2H-pyran-4-aminium chloride

TAK-779 Chemical Structure

TAK-779(Cl)

CS-2889

TAK-779;TAK 779;TAK779

TAK-779 >=98% (HPLC)

TAK-779,TAK 779,CCR,HIV,Human immunodeficiency virus,Takeda779,Takeda-779,TAK779,CXCR,inhibit,CXC chemokine receptors,CC chemokine receptor,Inhibitor

N,N-Dimethyl-N-(4-(2-(p-tolyl)-6,7-dihydro-5H-benzo[7]annulene-8-carboxamido)benzyl)tetrahydro-2H-pyran-4-aminium chloride

TAK-779, 10 mM in DMSO

TAK-779 (TAK779

229005-80-5