ChemicalBook > CAS DataBase List > Soticlestat

Soticlestat

Product Name
Soticlestat
CAS No.
1429505-03-2
Chemical Name
Soticlestat
Synonyms
OV935;TAK-935;Soticlestat;Soticlestat??(TAK-935;Soticlestat/TAK-935/OV935;Soticlestat, 10 mM in DMSO;2,4’-Bipyridin]-3-yl(4-benzyl-4-hydroxy-1-piperidyl)methanone;2,4'-Bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone;[2,4'-Bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone;Methanone, [2,4'-bipyridin]-3-yl[4-hydroxy-4-(phenylmethyl)-1-piperidinyl]-
CBNumber
CB54668528
Molecular Formula
C23H23N3O2
Formula Weight
373.45
MOL File
1429505-03-2.mol
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Soticlestat Property

solubility 
DMSO: soluble
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0078356
Product name
Soticlestat
Packaging
5mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0078356
Product name
Soticlestat
Packaging
10mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0078356
Product name
Soticlestat
Packaging
25mg
Price
$650
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573114
Product name
Soticlestat
Purity
>98%
Packaging
10mg
Price
$690.2
Updated
2021/12/16
ChemScene
Product number
CS-0078356
Product name
Soticlestat
Packaging
50mg
Price
$950
Updated
2021/12/16
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Soticlestat Chemical Properties,Usage,Production

Uses

Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research[1][2].

in vivo

Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus[1].

Animal Model:Amyloid precursor protein and presenilin 1 (APP/PS1-Tg) mice (7-week-old)[1]
Dosage:10 mg/kg
Administration:Oral administration; once daily; for 1 days, 3 days and 7 days
Result:Lowered brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%.

References

[1] Toshiya Nishi, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081. DOI:10.1038/s41598-020-74036-6
[2] Krista Eschbach, et al. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388. DOI:10.1080/17512433.2019.1605904

Soticlestat Preparation Products And Raw materials

Raw materials

Preparation Products

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Soticlestat Suppliers

China 43 United States 4 Global 47
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39999
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2992
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9550
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
9955
Advantage
58
Kaixin Chemical (Hong Kong) Limited
Tel
010-88886666-01 13112345678
Fax
CDXH21@126.com
Email
loyson@tcypharm.com
Country
China
ProdList
597
Advantage
55

1429505-03-2, SoticlestatRelated Search:

Mobocertinib Tak 799 TAK-960 TAK-632 TAK875 TAK-733 Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]- 6-[(7S)-7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthalenecarboxamide

  • Soticlestat
  • TAK-935
  • Methanone, [2,4'-bipyridin]-3-yl[4-hydroxy-4-(phenylmethyl)-1-piperidinyl]-
  • OV935
  • Inhibitor,CYP46A1,inhibit,cholesterol,24-hydroxylase,OV 935,Soticlestat,NMDA,antiepileptic,TAK935,CYPs,epilepsy,TAK 935,Cytochrome P450,OV-935
  • 2,4’-Bipyridin]-3-yl(4-benzyl-4-hydroxy-1-piperidyl)methanone
  • Soticlestat/TAK-935/OV935
  • 2,4'-Bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone
  • Soticlestat??(TAK-935
  • Soticlestat, 10 mM in DMSO
  • [2,4'-Bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone
  • 1429505-03-2