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Soticlestat

Product Name
Soticlestat
CAS No.
1429505-03-2
Chemical Name
Soticlestat
Synonyms
OV935;TAK-935;Soticlestat;Soticlestat??(TAK-935;Soticlestat/TAK-935/OV935;Soticlestat, 10 mM in DMSO;2,4’-Bipyridin]-3-yl(4-benzyl-4-hydroxy-1-piperidyl)methanone;2,4'-Bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone;Methanone, [2,4'-bipyridin]-3-yl[4-hydroxy-4-(phenylmethyl)-1-piperidinyl]-;Inhibitor,CYP46A1,inhibit,cholesterol,24-hydroxylase,OV 935,Soticlestat,NMDA,antiepileptic,TAK935,CYPs,epilepsy,TAK 935,Cytochrome P450,OV-935
CBNumber
CB54668528
Molecular Formula
C23H23N3O2
Formula Weight
373.45
MOL File
1429505-03-2.mol
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Soticlestat Property

solubility 
DMSO: soluble
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0078356
Product name
Soticlestat
Packaging
5mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0078356
Product name
Soticlestat
Packaging
10mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0078356
Product name
Soticlestat
Packaging
25mg
Price
$650
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573114
Product name
Soticlestat
Purity
>98%
Packaging
10mg
Price
$690.2
Updated
2021/12/16
ChemScene
Product number
CS-0078356
Product name
Soticlestat
Packaging
50mg
Price
$950
Updated
2021/12/16
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Soticlestat Chemical Properties,Usage,Production

Uses

Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research[1][2].

in vivo

Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus[1].

Animal Model:Amyloid precursor protein and presenilin 1 (APP/PS1-Tg) mice (7-week-old)[1]
Dosage:10 mg/kg
Administration:Oral administration; once daily; for 1 days, 3 days and 7 days
Result:Lowered brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%.

References

[1] Toshiya Nishi, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081. DOI:10.1038/s41598-020-74036-6
[2] Krista Eschbach, et al. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388. DOI:10.1080/17512433.2019.1605904

Soticlestat Preparation Products And Raw materials

Raw materials

Preparation Products

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Soticlestat Suppliers

China 34 United States 4 Global 38
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71829
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2967
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9323
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58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
10499
Advantage
58
Kaixin Chemical (Hong Kong) Limited
Tel
010-88886666-01 13112345678
Fax
CDXH21@126.com
Email
loyson@tcypharm.com
Country
China
ProdList
596
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32159
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58

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  • Soticlestat
  • TAK-935
  • Methanone, [2,4'-bipyridin]-3-yl[4-hydroxy-4-(phenylmethyl)-1-piperidinyl]-
  • OV935
  • Inhibitor,CYP46A1,inhibit,cholesterol,24-hydroxylase,OV 935,Soticlestat,NMDA,antiepileptic,TAK935,CYPs,epilepsy,TAK 935,Cytochrome P450,OV-935
  • 2,4’-Bipyridin]-3-yl(4-benzyl-4-hydroxy-1-piperidyl)methanone
  • Soticlestat/TAK-935/OV935
  • 2,4'-Bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone
  • Soticlestat??(TAK-935
  • Soticlestat, 10 mM in DMSO
  • 1429505-03-2