ChemicalBook > CAS DataBase List > 4-(Trifluoromethyl)nicotinonitrile

4-(Trifluoromethyl)nicotinonitrile

Product Name
4-(Trifluoromethyl)nicotinonitrile
CAS No.
13600-43-6
Chemical Name
4-(Trifluoromethyl)nicotinonitrile
Synonyms
BUTTPARK 43\57-45;4-(TRIFLUOROMETHYL)NICOTINONITRILE;4-TRIFLUOROMETHYL-3-PYRIDINENITRILE;3-CYANO-4-(TRIFLUOROMETHYL)PYRIDINE;3-Cyano-4-(trifluoromethyl)pyridine95+%;4-(Trifluoromethyl)nicotinonitrile 95+%;4-(trifluoroMethyl)pyridine-3-carbonitrile;4-(Trifluoromethyl)-3-pyridinecarbonitrile;4-(Trifluoromethyl)Nicotinonitrile(WX683324);3-Pyridinecarbonitrile, 4-(trifluoromethyl)-
CBNumber
CB5469325
Molecular Formula
C7H3F3N2
Formula Weight
172.11
MOL File
13600-43-6.mol
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4-(Trifluoromethyl)nicotinonitrile Property

Boiling point:
75-77°C 15mm
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at room temperature
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Oil
pka
-0.57±0.18(Predicted)
color 
Colourless
InChI
InChI=1S/C7H3F3N2/c8-7(9,10)6-1-2-12-4-5(6)3-11/h1-2,4H
InChIKey
DHIRCRHQLUNYDS-UHFFFAOYSA-N
SMILES
C1=NC=CC(C(F)(F)F)=C1C#N
CAS DataBase Reference
13600-43-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn,T
Risk Statements 
36/37/38-20/21/22-25
Safety Statements 
26-36-36/37-45
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
C987898
Product name
3-Cyano-4-(trifluoromethyl)pyridine
Packaging
500mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
001381
Product name
3-Cyano-4-(trifluoromethyl)pyridine
Purity
95%
Packaging
5g
Price
$279
Updated
2021/12/16
SynQuest Laboratories
Product number
3H37-3-X3
Product name
3-Cyano-4-(trifluoromethyl)pyridine
Purity
95.0%
Packaging
10g
Price
$285
Updated
2021/12/16
SynQuest Laboratories
Product number
3H37-3-X3
Product name
3-Cyano-4-(trifluoromethyl)pyridine
Purity
95.0%
Packaging
5G
Price
$154
Updated
2021/12/16
Apolloscientific
Product number
PC2108B
Product name
4-(Trifluoromethyl)nicotinonitrile
Purity
95+%
Packaging
10g
Price
$178
Updated
2021/12/16
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4-(Trifluoromethyl)nicotinonitrile Chemical Properties,Usage,Production

Chemical Properties

Pale yellow solid

Definition

ChEBI: 4-(Trifluoromethyl)nicotinonitrile is a member of pyridines and a nitrile.

Synthesis

533932-97-7

533932-96-6

13600-43-6

The general procedure for the synthesis of 3-cyano-4-trifluoromethylpyridine (Compound VIIb) from Compound (CAS:533932-97-7) and Compound (CAS:533932-96-6) is as follows (refer to Example 5): Step F: To a solution of 28% sodium methanol (580 mg, 3.0 mmol) in methanol (5 mL) was added a methanol solution of 3-[(4,4,4-trifluoro-3-oxo-1-butenyl)amino]-2-propenenenitrile (a mixture of IIa and IIb; 380 mg, 2.0 mmol), and the reaction mixture was stirred and then refluxed for 2 hours at room temperature. After completion of the reaction, the reaction solution was poured into water and extracted with ethyl acetate. The organic layers were combined, washed with brine, dried over magnesium sulfate and then concentrated. The resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate = 3/1) to give 195 mg (56.5% yield) of the target compound 3-cyano-4-trifluoromethylpyridine. 1H-NMR spectrum (200 MHz, CD3OD) δ (ppm): 9.11 (1H, s), 9.03 (1H, d, J=5.1 Hz), 7.72 (1H, d, J=5.1 Hz).

References

[1] Patent: EP1460071, 2004, A1. Location in patent: Page 39
[2] Patent: EP1460071, 2004, A1. Location in patent: Page 40

4-(Trifluoromethyl)nicotinonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(Trifluoromethyl)nicotinonitrile manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-(Trifluoromethyl)nicotinonitrile 13600-43-6
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Henan Fengda Chemical Co., Ltd
Product
4-(Trifluoromethyl)nicotinonitrile 13600-43-6
Price
US $36.00-1.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-(Trifluoromethyl)nicotinonitrile 13600-43-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

13600-43-6, 4-(Trifluoromethyl)nicotinonitrileRelated Search:

4-(Trifluoromethyl)pyridine (Trifluoromethyl)trimethylsilane 4-Aminobenzotrifluoride Benzotrifluoride 4-(Trifluoromethyl)nicotinic acid 2,6-Lutidine 2,4,6-Collidine 3-Cyanopyridine 2-Methylbenzotrifluoride 4-Methylpyridine 4-Bromobenzotrifluoride Azamethiphos 3-Trifluoromethylpyridine Pyridine Lithium trifluoromethanesulfonate 2-(Trifluoromethyl)pyridine 4-(Trifluoromethyl)benzaldehyde 3-Cyano-4-methylpyridine

  • BUTTPARK 43\57-45
  • 3-Cyano-4-(trifluoromethyl)pyridine95+%
  • 3-CYANO-4-(TRIFLUOROMETHYL)PYRIDINE
  • 4-TRIFLUOROMETHYL-3-PYRIDINENITRILE
  • 4-(TRIFLUOROMETHYL)NICOTINONITRILE
  • 4-(trifluoroMethyl)pyridine-3-carbonitrile
  • 4-(Trifluoromethyl)Nicotinonitrile(WX683324)
  • 3-Cyano-4-(trifluoromethyl)pyridine, 4-(Trifluoromethyl)pyridine-3-carbonitrile
  • 4-(Trifluoromethyl)nicotinonitrile 95+%
  • 3-CYANO-4-(TRIFLUOROMETHYL) PYRIDINE(NON-HAZARDOUS LABORATORY REAGENTS)
  • 3-Pyridinecarbonitrile, 4-(trifluoromethyl)-
  • 4-(Trifluoromethyl)nicotinonitrile ISO 9001：2015 REACH
  • 4-(Trifluoromethyl)-3-pyridinecarbonitrile
  • 13600-43-6
  • C7H3F3N2
  • Pyridines
  • Pyridine
  • Boron, Nitrile, Thio,& TM-Cpds
  • Heterocycles