TYRPHOSTIN B46

ChemicalBook > CAS DataBase List > TYRPHOSTIN B46

Product Name: TYRPHOSTIN B46
CAS No.: 133550-34-2
Chemical Name: TYRPHOSTIN B46
Synonyms: AG 555;AG 555, >98%;TYRPHOSTIN B46;TYRPHOSTIN AG 555;TyrphostinB46 AG 555;TyrphostinB46 A 555;AG555（Tyrphostin B46）;TYRPHOSTIN AG 555, >98%;AG 555 (Tyrphostin AG 555);TYRPHOSTIN AG 555;TYRPHOSTIN AG-555;TYRPHOSTIN AG555
CBNumber: CB5469835
Molecular Formula: C19H18N2O3
Formula Weight: 322.36
MOL File: 133550-34-2.mol

Less

TYRPHOSTIN B46 Property

Boiling point:: 621.1±55.0 °C(Predicted)
Density: 1.273±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO or ethanol: soluble
pka: 8.82±0.10(Predicted)
form: Powder
color: Light yellow to yellow

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Alfa Aesar

Product number: J61704
Product name: Tyrphostin B46, 98+%
Packaging: 10mg
Price: $152.65
Updated: 2024/03/01

Alfa Aesar

Product number: J61704
Product name: Tyrphostin B46, 98+%
Packaging: 50mg
Price: $644
Updated: 2021/12/16

Cayman Chemical

Product number: 23247
Product name: AG-555
Purity: ≥95%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 23247
Product name: AG-555
Purity: ≥95%
Packaging: 10mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 23247
Product name: AG-555
Purity: ≥95%
Packaging: 25mg
Price: $198
Updated: 2024/03/01

Less

TYRPHOSTIN B46 Chemical Properties,Usage,Production

Description

AG-555 is a tyrphostin inhibitor of the EGF receptor (EGFR; IC₅₀ = 0.7 μM). It selectively inhibits EFGR over ErbB2 (IC₅₀ = 35 μM). AG-555 inhibits EGF-dependent growth of HER 14 cells (IC₅₀ = 2.5 μM) as well as the growth of psoriatic keratinocytes isolated from patients with psoriasis when used at concentrations ranging from 1 to 50 μM. It also inhibits Moloney murine leukemia virus (Mo-MuLV) reverse transcriptase activity (IC₅₀ = 10.8 μM) without affecting Mo-MuLV-infected NIH3T3 cell growth (IC₅₀ = 210 μM).

Uses

Inhibitor of EGF receptor kinase activity

Biological Activity

Potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 0.7 μ M) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G 1 growth arrest selectively in transformed cells (IC 50 values are 6.4 and 9.4 μ M in HPV16-immortalized and normal keratinocytes respectively).

References

[1]. ben-bassat h, rosenbaum-mitrani s, hartzstark z, et al. inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes. cancer res, 1997, 57(17): 3741-3750.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. sion-vardy n, vardy d, rodeck u, et al. antiproliferative effects of tyrosine kinase inhibitors (tyrphostins) on human bladder and renal carcinoma cells. j surg res, 1995, 59(6): 675-680.
[4]. seri i, aflalo e, gazit a, et al. tyrphostin ag-555 inhibits early and late stages of moloney murine leukemia virus replication cycle. int j oncol, 1997, 10(6): 1185-1189.

TYRPHOSTIN B46 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

TYRPHOSTIN B46 Suppliers

China 57 Germany 2 India 1 Switzerland 2 United Kingdom 3 United States 18 USA 1 Global 84

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 5926
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7298
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1925
Advantage: 55

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3254
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Jingmo (Xiamen) Biotechnology Co., Ltd

Tel: 13621943973; 13621943973
Email: sales@jamxmpharmatech.com
Country: China
ProdList: 1114
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15342225168
Email: yutianchun2007@126.com
Country: China
ProdList: 10003
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44806
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Krain Pharmaceutical Technology CO.,Ltd

Tel: 18252089365
Email: Krain_kerun@163.com
Country: China
ProdList: 2615
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Henan yingchuang

Tel: 16650708709
Fax: qq:778660296
Email: hnyingchuang@163.com
Country: China
ProdList: 3924
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62075
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 9994
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 15162312715
Email: sales@szzxbio.com
Country: China
ProdList: 2990
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054 13417589054
Email: trendseenbio@gmail.com
Country: China
ProdList: 9470
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50749
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 6829
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29979
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48461
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.

Tel: 025-66061636 18013972705
Email: qqyang@aikonchem.com
Country: China
ProdList: 10238
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32956
Advantage: 60

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054
Email: trendseenbio@gmail.com
Country: China
ProdList: 11681
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Shize Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shizezjp@163.com
Country: CHINA
ProdList: 6174
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Beijing Taize Jiaye Technology Development Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6050
Advantage: 58

Shanghai Qiming Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6502
Advantage: 58

Shanghai Chaoyan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 471161314@qq.com
Country: CHINA
ProdList: 6210
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Shanghai Jingke Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jingkehuaxue@163.com
Country: CHINA
ProdList: 6972
Advantage: 58

Beijing Lebo Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6057
Advantage: 58

133550-34-2, TYRPHOSTIN B46Related Search:

TYRPHOSTIN A46 99%,TYRPHOSTIN A46 TYRPHOSTIN A46,AG 99 (Tyrphostin A46) TYRPHOSTIN B46 2-CYANO-3-(3,4-DIHYDROXY-5-IODO-PHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE CHEMBRDG-BB 9071188 TYRPHOSTIN AG 1024 TYRPHOSTIN RG 14620 TYRPHOSTIN B48 TYRPHOSTIN RG 13022

N-(3-PHENYLPROPYL)-3,4-DIHYDROXY-ALPHA CYANOCINNAMIDE

N-(3'-PHENYLPROPYL)-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE

TYRPHOSTIN AG 555

TYRPHOSTIN B46

(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(3-PHENYLPROPYL)-2-PROPENAMIDE

AG 555

ALPHA-CYANO-(3,4-DIHYDROXY)-N-(3-PHENYLPROPYL)CINNAMIDE

Tyrphostin B46, N-(3μ-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide

AG 555 (Tyrphostin AG 555)

2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-, (2E)-

TYRPHOSTIN AG 555;TYRPHOSTIN AG-555;TYRPHOSTIN AG555

AG 555, >98%

TYRPHOSTIN AG 555, >98%

AG555（Tyrphostin B46）

(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)acrylamide

Tyrphostin AG-555,EGFR,Reverse Transcriptase,Bovine,Tyrphostin AG555,HER1,BPV,ErbB-1,Inhibitor,AG 555,Epidermal growth factor receptor,AG-555,AG555,inhibit,antiretroviral,Papillomavirus

TyrphostinB46 AG 555

TyrphostinB46 A 555

AG 555 (Tyrphostin B46), EGFR-tyrosine kinase inhibitor

133550-34-2

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Kinase/Phosphatase Biology

Epidermal Growth Factor Receptor (EGFR)

Receptor Tyrosine Kinase Inhibitors

Protein Kinase

Intracellular Signaling