TYRPHOSTIN B46

ChemicalBook > CAS DataBase List > TYRPHOSTIN B46

Product Name: TYRPHOSTIN B46
CAS No.: 133550-34-2
Chemical Name: TYRPHOSTIN B46
Synonyms: AG 555;AG 555, >98%;TYRPHOSTIN B46;TYRPHOSTIN AG 555;TyrphostinB46 AG 555;AG555（Tyrphostin B46）;TYRPHOSTIN AG 555, >98%;AG 555 (Tyrphostin AG 555);TYRPHOSTIN AG 555;TYRPHOSTIN AG-555;TYRPHOSTIN AG555;N-(3-PHENYLPROPYL)-3,4-DIHYDROXY-ALPHA CYANOCINNAMIDE
CBNumber: CB5469835
Molecular Formula: C19H18N2O3
Formula Weight: 322.36
MOL File: 133550-34-2.mol

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TYRPHOSTIN B46 Property

Boiling point:: 621.1±55.0 °C(Predicted)
Density: 1.273±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO or ethanol: soluble
pka: 8.82±0.10(Predicted)
form: Powder

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J61704
Product name: Tyrphostin B46, 98+%
Packaging: 10mg
Price: $152.65
Updated: 2024/03/01

Alfa Aesar

Product number: J61704
Product name: Tyrphostin B46, 98+%
Packaging: 50mg
Price: $644
Updated: 2021/12/16

Cayman Chemical

Product number: 23247
Product name: AG-555
Purity: ≥95%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 23247
Product name: AG-555
Purity: ≥95%
Packaging: 10mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 23247
Product name: AG-555
Purity: ≥95%
Packaging: 25mg
Price: $198
Updated: 2024/03/01

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TYRPHOSTIN B46 Chemical Properties,Usage,Production

Description

AG-555 is a tyrphostin inhibitor of the EGF receptor (EGFR; IC₅₀ = 0.7 μM). It selectively inhibits EFGR over ErbB2 (IC₅₀ = 35 μM). AG-555 inhibits EGF-dependent growth of HER 14 cells (IC₅₀ = 2.5 μM) as well as the growth of psoriatic keratinocytes isolated from patients with psoriasis when used at concentrations ranging from 1 to 50 μM. It also inhibits Moloney murine leukemia virus (Mo-MuLV) reverse transcriptase activity (IC₅₀ = 10.8 μM) without affecting Mo-MuLV-infected NIH3T3 cell growth (IC₅₀ = 210 μM).

Uses

Inhibitor of EGF receptor kinase activity

Biological Activity

Potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 0.7 μ M) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G 1 growth arrest selectively in transformed cells (IC 50 values are 6.4 and 9.4 μ M in HPV16-immortalized and normal keratinocytes respectively).

References

[1]. ben-bassat h, rosenbaum-mitrani s, hartzstark z, et al. inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes. cancer res, 1997, 57(17): 3741-3750.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. sion-vardy n, vardy d, rodeck u, et al. antiproliferative effects of tyrosine kinase inhibitors (tyrphostins) on human bladder and renal carcinoma cells. j surg res, 1995, 59(6): 675-680.
[4]. seri i, aflalo e, gazit a, et al. tyrphostin ag-555 inhibits early and late stages of moloney murine leukemia virus replication cycle. int j oncol, 1997, 10(6): 1185-1189.

TYRPHOSTIN B46 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN B46 Suppliers

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133550-34-2, TYRPHOSTIN B46Related Search:

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133550-34-2

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Kinase/Phosphatase Biology

Epidermal Growth Factor Receptor (EGFR)

Receptor Tyrosine Kinase Inhibitors

Protein Kinase

Intracellular Signaling