CP-24879 HYDROCHLORIDE
- Product Name
- CP-24879 HYDROCHLORIDE
- CAS No.
- 10141-51-2
- Chemical Name
- CP-24879 HYDROCHLORIDE
- Synonyms
- CP-24879;CP-24879 HCl;p-isopentoxyaniline;CP-24879 HYDROCHLORIDE;Benzenamine, 4-(3-methylbutoxy)-;P-ISOPENTOXYANILINE HYDROCHLORIDE;a€￠ Benzenamine, 4-(3-methylbutoxy)-;CP-24879 hydrochloride, 10 mM in DMSO;4-(Isopentyloxy)aniline hydrochloride;P-(ISOPENTYLOXY)-ANILINE HYDROCHLORIDE
- CBNumber
- CB5472334
- Molecular Formula
- C11H18ClNO
- Formula Weight
- 215.72
- MOL File
- 10141-51-2.mol
CP-24879 HYDROCHLORIDE Property
- Melting point:
- 154-159 °C
- storage temp.
- room temp
- solubility
- DMSO: 22 mg/mL
- form
- solid
- color
- off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C9115
- Product name
- CP-24879 hydrochloride
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $222
- Updated
- 2025/07/31
- Product number
- C9115
- Product name
- CP-24879 hydrochloride
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $808
- Updated
- 2023/01/07
- Product number
- 10120
- Product name
- CP 24,879 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $31
- Updated
- 2024/03/01
- Product number
- 10120
- Product name
- CP 24,879 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $133
- Updated
- 2024/03/01
- Product number
- 10120
- Product name
- CP 24,879 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $234
- Updated
- 2024/03/01
CP-24879 HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2].
Biochem/physiol Actions
delta5/delta6 (Δ5/Δ6) desaturase inhibitor.
in vivo
CP-24879 (hydrochloride) (3 mg/kg, IP, three times a day, for 6 or 4 days) inhibits Δ6 + Δ5 desaturase activities in vivo, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice[1].
CP-24879 (hydrochloride) (33 mg/kg, IV, once) is cleared quite rapidly and has a relatively short half-life[1].
| Animal Model: | Chow-fed and EFAD Balb/C mice (N = 5/group) [1] |
| Dosage: | 3 mg/kg |
| Administration: | IP, three times a day, for 6 or 4 days |
| Result: | Inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively). |
| Animal Model: | Swiss-Webster mice (male, 25 g) [1] |
| Dosage: | 33 mg/kg |
| Administration: | IV in the tail vein, once (Pharmacokinetic Analysis) |
| Result: | Was readily distributed to the peripheral tissues, with the volume of distribution (V) of 1.9 mL/g, was cleared quite rapidly (CL = 0.56 mL/min) and had a relatively short half-life (T1/2 = 59 min). |
References
[1] Obukowicz MG, et al. Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem Pharmacol. 1998 Apr 1;55(7):1045-58. DOI:10.1016/s0006-2952(97)00665-5
[2] [2]López-Vicario C, et al. Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut. 2014 Feb;63(2):344-55. DOI:10.1136/gutjnl-2012-303179
[3] [3]Lee JY, Nam M, Son HY, et al. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci U S A. 2020;117(51):32433-32442. DOI:10.1073/pnas.2006828117
CP-24879 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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