3-HYDROXYPYRAZINE-2-CARBOXAMIDE

Product Name: 3-HYDROXYPYRAZINE-2-CARBOXAMIDE
CAS No.: 55321-99-8
Chemical Name: 3-HYDROXYPYRAZINE-2-CARBOXAMIDE
Synonyms: Favipiravir Impurity;(3-BROMOPYRIDIN-4-...;T-1105, 10 mM in DMSO;Favipiravir intermediate;Favipiravir Desfluoro Impurity;3-HYDROXYPYRAZINE-2-CARBOXAMINE;3-HYDROXYPYRAZINE-2-CARBOXAMIDE;3-Hydroxy-2-pyrazinecarboxamide;Pyrazine-2-carboxamide, 3-hydroxy-;3-Hydroxypyrazine-2-carboxamide>
CBNumber: CB5478811
Molecular Formula: C5H5N3O2
Formula Weight: 139.11
MOL File: 55321-99-8.mol

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3-HYDROXYPYRAZINE-2-CARBOXAMIDE Property

Melting point:: ca 270℃
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Aqueous Base (Slightly)
form: Solid
pka: 10.69±0.40(Predicted)
color: Pale Brown to Brown
λmax: 348nm(lit.)
Stability:: Hygroscopic
InChI: InChI=1S/C5H5N3O2/c6-4(9)3-5(10)8-2-1-7-3/h1-2H,(H2,6,9)(H,8,10)
InChIKey: SZPBAPFUXAADQV-UHFFFAOYSA-N
SMILES: C1(C(N)=O)=NC=CNC1=O

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-37
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H1485
Product name: 3-Hydroxypyrazine-2-carboxamide
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: H1485
Product name: 3-Hydroxypyrazine-2-carboxamide
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $148
Updated: 2025/07/31

TRC

Product number: D454150
Product name: 3,4-Dihydro-3-oxo-2-pyrazinecarboxamide
Packaging: 2.5g
Price: $185
Updated: 2021/12/16

Apolloscientific

Product number: OR917252
Product name: 3-Hydroxypyrazine-2-carboxamide
Purity: 98%
Packaging: 25g
Price: $194
Updated: 2021/12/16

Matrix Scientific

Product number: 143886
Product name: 3-Hydroxypyrazine-2-carboxamide
Purity: 95%
Packaging: 5g
Price: $452
Updated: 2021/12/16

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3-HYDROXYPYRAZINE-2-CARBOXAMIDE Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

Apart from biological importance of pyridine-2-carboxamide (picolinamide, pia) as well as of its derivatives such as 3-hydroxypyridine-2-carboxamide (3-OHpia), as ligands they have found their extensive application in coordina- tion chemistry in crystal engineering .

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 78, 1949 DOI: 10.1021/ja01169a023

Synthesis

131543-46-9

62009-47-6

55321-99-8

The general procedure for the synthesis of 3-hydroxypyrazine-2-carboxamide from the compound (CAS:131543-46-9) and 2-aminomalonamide was carried out as follows: firstly, diethylaminomalonate (in the form of hydrochloric acid) was dissolved in water, and pH was adjusted by adding sodium bicarbonate to a value greater than 7. Subsequently, an extraction operation was carried out, and the organic phase was evaporated under reduced pressure. The product obtained was quantitatively converted to aminodicarbonamide by treating the product with an aqueous ammonia solution at 80 °C overnight. The product obtained in this step does not require further purification and can be directly dissolved in water for the next reaction. Next, glyoxal sodium bisulfite hemihydrate was added to this aqueous solution and the reaction mixture was stirred at 90°C for 3 hours. After completion of the reaction, the reaction mixture was adjusted to alkaline with 58% NH4OH solution. A 30% H2O2 solution was added dropwise to the rapidly stirred cold solution at 0°C. The reaction mixture was allowed to stand at room temperature to induce precipitation of 2-hydroxy-3-carboxamide pyrazine. Finally, the solid product was collected in 63% yield and purified by partial recrystallization. References: [J. Med. Chem. 1983, 26, 283-86], [J. Heterocyclic Chem. 1979, 16, 193].

References

[1] Patent: WO2007/144686, 2007, A1. Location in patent: Page/Page column 129-130
[2] Patent: JP5739618, 2015, B2. Location in patent: Paragraph 0024
[3] Patent: US2018/141920, 2018, A1. Location in patent: Paragraph 0215; 0216; 0217; 0218; 0219; 0220; 0221; 0222

3-HYDROXYPYRAZINE-2-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-HYDROXYPYRAZINE-2-CARBOXAMIDE Suppliers

Americas 1 China 167 China Hong Kong 1 Europe 2 India 7 Japan 2 United Kingdom 3 United States 15 Global 198

Pure Chemistry Scientific Inc.

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View Lastest Price from 3-HYDROXYPYRAZINE-2-CARBOXAMIDE manufacturers

Wuhan Monad Medicine Tech Co.,LTD

Product: 3-HYDROXYPYRAZINE-2-CARBOXAMIDE 55321-99-8
Price: US $10.00/KG
Min. Order: 25Kg/Drum
Purity: 99.99%
Supply Ability: 20 tons/month
Release date: 2021-04-20

Shaanxi Dideu Medichem Co. Ltd

Product: 3-hydroxypyrazine-2-carboxamide 55321-99-8
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 800 tons
Release date: 2020-04-29

Career Henan Chemical Co

Product: 3-HYDROXYPYRAZINE-2-CARBOXAMIDE 55321-99-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-01

55321-99-8, 3-HYDROXYPYRAZINE-2-CARBOXAMIDERelated Search:

Methyl 6-bromo-3-oxo-3,4-dihydropyrazine-2-carboxylate 6-Bromo-3-chloropyrazine-2-carbonitrile 3-Chloropyrazine-2-carbonitrile Pyrazinecarboxamide, 3,6-difluoro- (9CI) 3-OXO-3,4-DIHYDROPYRAZINE-2-CARBONITRILE 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-, coMpd. with N-cyclohexylcyclohexanaMine (1:1) 2-HYDROXYPYRAZINE 2-Pyrazinecarbonitrile, 3-fluoro- Cefepime 3,6-DibroMopyrazine-2-carbonitrile Pyrazinecarboxamide, 6-fluoro- (9CI) Pyrazinecarboxamide, 5-fluoro-3,4-dihydro-3-oxo- (9CI) 3-HYDROXYPYRAZINE-2-CARBOXAMIDE (3-METHOXY-PYRAZIN-2-YL)-MORPHOLIN-4-YL-METHANONE 5-Hydroxypyrazine-2-carboxamide BUTTPARK 91\04-18 SALOR-INT L101621-1EA 3-HYDROXY-5,6-DIPHENYL-2-PYRAZINECARBOXAMIDE

3-Hydroxy-2-pyrazinecarboxamide

Pyrazine-2-carboxamide, 3-hydroxy-

Pyrazinecarboxamide, 3,4-dihydro-3-oxo-

3-HYDROXYPYRAZINE-2-CARBOXAMIDE

3-Hydroxypyrazine-2-carboxylic acid amide

Pyrazinecarboxamide, 3,4-dihydro-3-oxo- (9CI)

Favipiravir intermediate

Favipiravir Impurity

(3-BROMOPYRIDIN-4-...

3-HYDROXYPYRAZINE-2-CARBOXAMINE

3,4-Dihydro-3-oxo-2-pyrazinecarboxaMide

3-Hydroxypyrazine-2-carboxamide,98%

3-Hydroxypyrazine-2-carboxamide&gt

Favipiravir Desfluoro Impurity

2-Pyrazinecarboxamide, 3,4-dihydro-3-oxo-

3-HYDROXYPYRAZINE-2-CARBOXAMIDE ISO 9001：2015 REACH

3-Oxo-3,4-dihydropyrazine-2-carboxamide

inhibit,T1105,antiviral,T-1105,T 1105,parainfluenza-3 virus,Inhibitor,Punta Toro virus,Influenza Virus,ZIKV strain SZ01,anti-RNA virus

3,4-Dihydro-3-oxopyrazine-2-carboxamide (Defluorofavipiravir)

T-1105, 10 mM in DMSO

55321-99-8

AMIDE

Pyrazines