(4-Methoxybenzyloxy)acetic acid
- Product Name
- (4-Methoxybenzyloxy)acetic acid
- CAS No.
- 88920-24-5
- Chemical Name
- (4-Methoxybenzyloxy)acetic acid
- Synonyms
- p-methoxybenzyloxy acetic acid;(4-METHOXYBENZYLOXY)ACETIC ACID;2-((4-Methoxybenzyl)oxy)acetic acid;Acetic acid, 2-[(4-methoxyphenyl)methoxy]-
- CBNumber
- CB5479595
- Molecular Formula
- C10H12O4
- Formula Weight
- 196.2
- MOL File
- 88920-24-5.mol
(4-Methoxybenzyloxy)acetic acid Property
- Melting point:
- 50.8-51.8 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
- Boiling point:
- 367.4±22.0 °C(Predicted)
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.40±0.10(Predicted)
- color
- White to Off-White
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M331513
- Product name
- 2-((4-Methoxybenzyl)oxy)aceticAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J96289
- Product name
- 2-((4-Methoxybenzyl)oxy)aceticacid
- Packaging
- 250mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- Z5281
- Product name
- 2-((4-Methoxybenzyl)oxy)aceticacid
- Packaging
- 250mg
- Price
- $19
- Updated
- 2021/12/16
- Product number
- J96289
- Product name
- 2-((4-Methoxybenzyl)oxy)aceticacid
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- J96289
- Product name
- 2-((4-Methoxybenzyl)oxy)aceticacid
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
(4-Methoxybenzyloxy)acetic acid Chemical Properties,Usage,Production
Synthesis
79-08-3
105-13-5
88920-24-5
4-Methoxybenzyl alcohol (1 eq.) and bromoacetic acid (1.2 eq.) were dissolved in anhydrous tetrahydrofuran at 0 °C. Sodium hydride (60% w/w, mineral oil dispersion, 3 eq.) was added in three batches. The reaction mixture was stirred at 70 °C for 4 hours. After cooling to room temperature, water was added and the resulting mixture was washed with hexane. The aqueous phase was acidified to pH 2 with 1N hydrochloric acid and subsequently extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by silica gel column chromatography with hexane solution of 50% ethyl acetate as eluent gave (4-methoxybenzyloxy)acetic acid (0.51 g, 71% yield) as a colorless solid.1H NMR (500 MHz, CDCl3) δ 7.29 (m, 2H), 6.90 (m, 2H), 4.59 (s, 2H), 4.10 (s, 2H), 3.81 ( s, 3H).
References
[1] Bioorganic and medicinal chemistry letters, 2001, vol. 11, # 21, p. 2837 - 2841
[2] Synlett, 2012, vol. 23, # 19, p. 2845 - 2849
[3] Tetrahedron Letters, 2002, vol. 43, # 41, p. 7427 - 7429
[4] Patent: WO2014/144100, 2014, A2. Location in patent: Paragraph 00274
[5] Patent: WO2006/109729, 2006, A1. Location in patent: Page/Page column 138-139
(4-Methoxybenzyloxy)acetic acid Preparation Products And Raw materials
Raw materials
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