Romosozumab

Product Name: Romosozumab
CAS No.: 909395-70-6
Chemical Name: Romosozumab
Synonyms: AMG785;AMG 785;AMG-785;CDP7851;CDP-7851;CDP 7851;Romosozumab;Research Grade Romosozumab;Romosozumab - Osteoporosis;Research Grade Romosozumab(DHJ48701)
CBNumber: CB54805794
Formula Weight: 0
MOL File: Mol file

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Romosozumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Romosozumab Chemical Properties,Usage,Production

Uses

Romosozumab is a humanized monoclonal anti-sclerostin antibody, it promotes bone formation and inhibits bone resorption by inhibiting sclerostin. Romosozumab can be used for the research of osteoporosis[1][2].

in vivo

Romosozumab (30 mg/kg; s.c. twice a week for 10 weeks) converts trabecular rods into trabecular plates in cynomolgus monkeys^[1]. Romosozumab (3 and 30 mg/kg; s.c. once a week for 6 or 12 months) improves bone mass, architecture, and bone strength, and maintains bone quality at the same time in mature cynomolgus monkeys with 4 months post-ovariectomy^[2].

Animal Model:	Male cynomolgus monkeys^[1]
Dosage:	30 mg/kg
Administration:	Subcutaneous injection; 30 mg/kg twice a week for 10 weeks
Result:	Increased bone formation and plate-like trabecular morphology, and improved mechanical performance.

References

[1] Paik J, Scott LJ. Romosozumab: A Review in Postmenopausal Osteoporosis. Drugs Aging. 2020 Nov;37(11):845-855. DOI:10.1007/s40266-020-00793-8
[2] Ominsky MS, et al. Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys. J Bone Miner Res. 2017 Apr;32(4):788-801. DOI:10.1002/jbmr.3036

Romosozumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Romosozumab Suppliers

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909395-70-6, RomosozumabRelated Search:

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Romosozumab

Research Grade Romosozumab(DHJ48701)

AMG 785

AMG785

AMG-785

CDP 7851

CDP7851

CDP-7851

Romosozumab - Osteoporosis

Research Grade Romosozumab

909395-70-6